Navigation Links
Study identifies potential 'safe period' for hormone replacement use
Date:2/2/2009

A new study makes important new findings on the role of hormone use on the risk of breast cancer, confirming that the use of estrogen plus progesterone increases the risk of both ductal and lobular breast cancer far more than estrogen-only; suggesting a two-year "safe" period for the use of estrogen and progesterone; and finding that the increased risk for ductal cancers observed in long-term past users of hormone replacement therapy drops off substantially two years after hormone use is stopped. The study appears in CANCER, a peer-reviewed journal of the American Cancer Society.

Previous studies have shown that hormone replacement therapy after menopause increases the risk of breast cancer and that use of a regimen that includes both estrogen and progesterone is more detrimental for the breast than the use of estrogen alone. But more data from large prospective studies are needed to fully characterize the impact of exogenous hormones on breast cancer incidence by type of hormone preparation and histology of the cancer.

To investigate the association in more detail, American Cancer Society epidemiologists led by Eugenia E. Calle, PhD, did a prospective study of 68,369 postmenopausal women who were cancer-free at baseline in 1992. They examined the use of estrogen-only and estrogen and progesterone in current and former users of varying duration, and the subsequent risk of developing invasive ductal and lobular carcinoma of the breast. They also looked at whether the risk for each type of breast cancer and each type of hormone regimen varied by body mass index (BMI), stage of disease at diagnosis, and estrogen receptor (ER) and progesterone receptor (PR) status. For the present study, the follow-up period ended on June 30, 2005.

They confirmed the findings from previous work that estrogen and progesterone increases the risk of both ductal and lobular breast cancer far more estrogen alone. They also found the risk associated with use of estrogen and progesterone increases significantly and substantially within three years of beginning hormone use. The data showed no increased risk for women who used estrogen and progesterone for less than two years, potentially identifying a "safe" period for estrogen and progesterone use.

The study also found no increased risk of breast cancer in women who had stopped using estrogen and progesterone two or more years ago, suggesting a window of two to three years for the risks of estrogen and progesterone both to become apparent after initial use and to diminish after cessation. Few estimates of risk within two to three years of initiation and cessation are available, so these findings need replication in other large studies.

The study found the use of estrogen and progesterone was associated with a doubling of risk of lobular cancer after three years of use, and a doubling of risk of ductal cancer with 10 years of use. Estrogen-only use was not associated with increased risk of ductal cancer, even after 20 years of use, but was associated with a 50 percent increase in risk of lobular cancer after 10 years of use.


'/>"/>

Contact: David Sampson
david.sampson@cancer.org
American Cancer Society
Source:Eurekalert

Related medicine news :

1. Penn study finds link between Parkinsons disease genes and manganese poisoning
2. Study suggests that inflammation may be the link between extreme sleep durations and poor health
3. Study finds genetic link between sleep disorders and depression in young children
4. Stanford study prevents pancreatic tumor growth in mice by inhibiting key protein
5. Study of Iraq veterans traumatic brain injuries to be conducted by UB researchers
6. Study confirms persistence of diversity problems in academic medicine
7. Oncogene inhibits tumor suppressor to promote cancer: Study links B-RAF and LKB1
8. Perceptions and experiences of homeless youth vary by race, UCSF study shows
9. New Study: Protein in the Morning Helps Dieters Stay on Track and Keep Weight Off
10. New study explores the relationship between preterm birth and autism spectrum disorder
11. Study finds preemies more likely to score positive
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/6/2016)... (PRWEB) , ... December 06, 2016 , ... ... the launch of a Kickstarter crowd funding campaign ( http://kck.st/2g3a1so ) for the ... active alerts and even taking an EKG from the watch while sharing these ...
(Date:12/6/2016)... CA (PRWEB) , ... December 06, 2016 , ... 'Tis ... can disrupt daily routines. That means it's also the season when eating healthy, staying ... living with diabetes) on schedule is harder to do. , "Shopping trips, parties ...
(Date:12/6/2016)... ... December 06, 2016 , ... “Tatiana Sibirskaya: A Life ... story of sacrifice and enlightenment. , “Tatiana Sibirskaya: A Life Devoted ... looking for creative outlets, Carolyn gravitated toward writing through the inspiration of her ...
(Date:12/6/2016)... ... 06, 2016 , ... TopConsumerReviews.com recently gave a best-in-class 5 star rating to ... give freedom to people who need help getting around. For some, advancing age has ... period of rehabilitation after an illness or accident. There is a wide variety of ...
(Date:12/6/2016)... ... December 06, 2016 , ... "Add realistic flares and light leaks to ... from clip to clip with high quality 4K lens flare footage," said Christina Austin ... lens flares filmed on the RED Dragon. Utilizing the Dragon Sensor, TransFlare 4K Jewel ...
Breaking Medicine News(10 mins):
(Date:12/6/2016)... , Dec. 6, 2016  Viking Therapeutics, ... clinical-stage biopharmaceutical company focused on the development of ... announced that the U.S. Food and Drug Administration ... for the treatment of X-linked adrenoleukodystrophy (X-ALD).  VK0214 ... (TRß) agonist that selectively regulates the expression of ...
(Date:12/6/2016)... , Dec. 6, 2016 A new study ... of 340B (AIR 340B) projects the 340B Drug Pricing Program ... by which time it is expected to exceed $23 billion ... would see 340B purchases surpass current Medicare Part B drug ... The new study – based on analysis of data on ...
(Date:12/6/2016)... , Dec. 6, 2016  BioAtla, LLC, ... development of Conditionally Active Biologic (CAB) antibody ... Sinobioway Group Company, Limited (Sinobioway) selected their ... The specific program candidates and the targeted ... BioAtla and Sinobioway entered into a strategic ...
Breaking Medicine Technology: