Navigation Links
Study identifies potential new pathway for drug development
Date:12/10/2012

A newly found understanding of receptor signaling may have revealed a better way to design drugs. A study from Nationwide Children's Hospital suggests that a newly identified group of proteins, alpha arrestins, may play a role in cell signaling that is crucial to new drug development. The study appears in PLOS ONE.

More than one-third of drugs on the market work by targeting G protein-coupled receptors that control how cells communicate and function. With many hundreds of members, G protein-coupled receptors are the largest family of signaling receptors throughout the body.

Once a cell's G protein-coupled receptor binds with a natural ligand or a drug, intracellular G proteins and beta arrestins independently mediate various signals. Immediately following, beta arrestins block further signaling of G proteins and recruit proteins to remove the receptor to halt cell signaling. Those receptors can subsequently recycle to the cell surface or be destroyed.

"Receptor down regulation caused by beta arrestins can interfere with drug efficacy because the G protein-coupled receptor that the drug has been targeting is absent from the cell surface," said Carlos E. Alvarez, PhD, principal investigator in the Center for Molecular and Human Genetics at The Research Institute at Nationwide Children's Hospital and lead study author. "This is why patients who are prescribed long-term medication can become drug-tolerant and require higher and higher doses."

In some cases, a drug's ability to trigger beta arrestin effects and block G protein signaling is preferential. Take beta blockers, for example. As the name suggests, beta blockers interfere with the binding to the receptor for epinephrine and other stress hormones, weakening the hormones' effects and therefore being useful in treating irregular heartbeats, prevention of second heart attacks, hypertension and other conditions. Screening has revealed that the beta blocker Carved
'/>"/>

Contact: Erin Pope
Erin.Pope@NationwideChildrens.org
614-355-0495
Nationwide Children's Hospital
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Targeted Prostate Cancer Biopsies Might Improve Care: Study
2. ADHD Can Cause Lifelong Problems, Study Finds
3. Study of text messaging service shows participants prepared for motherhood
4. In vitro study finds digested formula, but not breast milk, is toxic to cells
5. New Blood Thinner May Help Prevent Leg Clots, Study Finds
6. Minimal Exercise Protects Senior’s Hearts According to Recent Study Reviewed By Projects for Natural Health Choices Inc.
7. Study finds association between oxygen deprivation before birth and ADHD
8. Brain study shows why some people are more in tune with what they want
9. VABC Responds to Study on Use of Cholesterol Lowering Drug Statins on Cancer Patients
10. Transvaginal Mesh Lawsuit Update: New Study Concerning Use of Vaginal Mesh in Prolapse Procedures, Bernstein Liebhard LLP Reports
11. Too Little Sleep Spurs Appetite-Boosting Hormones: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/22/2014)... undergoing a minimally invasive hysterectomy using electric power morcellation, ... at the time of the procedure, according to a ... concern that this procedure, in which the uterus is ... of undetected malignancies. , Despite the commercial availability of ... the prevalence of malignancy at the time of electric ...
(Date:7/22/2014)... Marc, Ph.D., director of research at the University of ... by the International Society of Eye Research (ISER) as ... 2014 Paul Kayser International Award in Retina Research., The ... has made a significant contribution to the understanding of ... this week at the ISER Biennial Meeting in San ...
(Date:7/22/2014)... -- The American Society of Hematology (ASH) will present ... Award for Lifetime Achievement in Hematology, to Kanti R. ... (LIJ) School of Medicine for his 50-year career combining ... mentoring, and exceptional patient care. , The Wallace ... bestowed on an individual who has been a vital ...
(Date:7/22/2014)... As reported on July 17, 2014 by ... name her favorite beauty products, “ Botox , that’s pretty ... “ Botox has changed my life” by halving the ... for her various, daily appearances. “Suddenly my eyelids are ... goo.gl/shmTQM). , “I think that Kelly Ripa’s response to the ...
(Date:7/22/2014)... Autoimmune disorders may share certain pathogenic mechanisms with cancer, ... (GW) researcher Linda Kusner, Ph.D. , published in ... paradigm shifting work shows that the very same inhibitors ... expressed in cells that produce autoimmune diseases. Henry ... at the GW School of Medicine and Health Sciences ...
Breaking Medicine News(10 mins):Health News:Study examines presence of uterine cancers at the time of hysterectomy using morcellation 2Health News:University of Utah researcher Robert Marc receives Paul Kayser International Award 2Health News:ASH honors Kanti R. Rai, M.D., with Coulter Award for Lifetime Achievement 2Health News:ASH honors Kanti R. Rai, M.D., with Coulter Award for Lifetime Achievement 3Health News:ASH honors Kanti R. Rai, M.D., with Coulter Award for Lifetime Achievement 4Health News:Celebrity Botox: Kelly Ripa Confesses to Getting Botox Injections 2Health News:New research finds pathogenic connection between autoimmune disorders and cancer 2
... -- New research finds that compared to mammograms, MRI screenings ... the likelihood that high-risk, underserved women who were specially targeted ... big catch. Researchers were able to reduce the cost of ... the usual $3,500 -- thanks to a grant. As a ...
... Ohio People living in poor neighborhoods are at ... hospital than are people who live in wealthier neighborhoods, ... neighborhoods of differing socioeconomic status and out-of-hospital deaths caused ... 1992 and 2002. In each community, and among whites ...
... Industries LLC announced today the opening of a new expanded ... Ltd. The new facility will double the production capacity ... immune support ingredient. , "We are proud to announce the ... the increasing demand from around the world," said Ken-ichi Kosuna, ...
... the Mining Microbial Genomes for Novel Antibiotics research theme ... a recipient of the 2011 National Institutes of Health ... from some of the nation,s most promising new scientists. ... of five years, supports young investigators who have proposed ...
... Interventional Radiology Foundation,s Discovery Campaign, which seeks to further ... of discovery, announced a major corporate pledge to that ... St. Jude Medical, has pledged $100,000 and is a ... Medical Foundation strengthens SIR Foundation,s Discovery Campaign as it ...
... fertility-awareness based method of family planning developed by researchers ... Center so effectively meets the needs of users that they ... study finds that women who follow the Standard Days Method, ... it effectively. Results of the large, multi-country study of 1659 ...
Cached Medicine News:Health News:MRI Can Spot Breast Cancer in High-Risk Women: Study 2Health News:Living in poor neighborhood a risk factor for out-of-hospital cardiac death 2Health News:Living in poor neighborhood a risk factor for out-of-hospital cardiac death 3Health News:Society of Interventional Radiology Foundation accepts St. Jude Medical Foundation gift 2Health News:Long-term effectiveness of new family planning method shown in study 2
(Date:7/22/2014)... 2014 Sanofi Pasteur, the vaccines division of Sanofi ... that the first lots of Fluzone ® (Influenza Vaccine) ... by the U.S. Food and Drug Administration (FDA) for distribution. ... first of at least 65 million doses of seasonal influenza ... U.S. health care providers and pharmacies in August. ...
(Date:7/22/2014)... AVIV, Israel , July 22, 2014 ... a clinical-stage biopharmaceutical company focused on the development and ... of liver diseases and cholesterol gallstones, announced today that ... cleared Galmed,s Investigational New Drug, or IND, application.  Such ... its product candidate, aramchol, in the United ...
(Date:7/22/2014)... , July 22, 2014  Neurotrope Bioscience, Inc., ... a world-wide, exclusive license agreement with the Icahn School ... ( Mount Sinai ) to utilize its ... Bryostatin-1 in the treatment of Niemann-Pick Type C Disease ... afflicted with Alzheimer-like symptoms. The license also covers other ...
Breaking Medicine Technology:Sanofi Pasteur Begins Shipping Seasonal Influenza Vaccine for Upcoming 2014-2015 Season in United States 2Sanofi Pasteur Begins Shipping Seasonal Influenza Vaccine for Upcoming 2014-2015 Season in United States 3Sanofi Pasteur Begins Shipping Seasonal Influenza Vaccine for Upcoming 2014-2015 Season in United States 4Sanofi Pasteur Begins Shipping Seasonal Influenza Vaccine for Upcoming 2014-2015 Season in United States 5Sanofi Pasteur Begins Shipping Seasonal Influenza Vaccine for Upcoming 2014-2015 Season in United States 6Sanofi Pasteur Begins Shipping Seasonal Influenza Vaccine for Upcoming 2014-2015 Season in United States 7Galmed Announces FDA Clearance of IND of Armachol for the Treatment of Fatty Liver Disorders 2Galmed Announces FDA Clearance of IND of Armachol for the Treatment of Fatty Liver Disorders 3Galmed Announces FDA Clearance of IND of Armachol for the Treatment of Fatty Liver Disorders 4Neurotrope Enters Collaborative Agreement with Icahn School of Medicine at Mount Sinai for use of Bryostatin-1 in the Treatment of Niemann-Pick Disease Type C 2Neurotrope Enters Collaborative Agreement with Icahn School of Medicine at Mount Sinai for use of Bryostatin-1 in the Treatment of Niemann-Pick Disease Type C 3Neurotrope Enters Collaborative Agreement with Icahn School of Medicine at Mount Sinai for use of Bryostatin-1 in the Treatment of Niemann-Pick Disease Type C 4Neurotrope Enters Collaborative Agreement with Icahn School of Medicine at Mount Sinai for use of Bryostatin-1 in the Treatment of Niemann-Pick Disease Type C 5
... The new Finnpipette Focus ... specifically to combine ergonomics with ... interchangeable handle plate offers a ... sizes. The new shorter tip ...
Inquire...
Pipetman F is a fixed-volume, air-displacement pipette. Thirteen robust models cover a large volume range from 2 L to 1000 L, with Gilsons legendary accuracy and precision....
Pipetman F is a fixed-volume, air-displacement pipette. Thirteen robust models cover a large volume range from 2 L to 1000 L, with Gilsons legendary accuracy and precision....
Medicine Products: