Navigation Links
Study identifies novel role for a protein that could lead to new treatments for rheumatoid arthritis
Date:5/22/2011

A new study by rheumatologists at Hospital for Special Surgery in New York has shown that a powerful pro-inflammatory protein, tumor necrosis factor (TNF), can also suppress aspects of inflammation. The researchers say the identification of the mechanism of how this occurs could potentially lead to new treatments for diseases such as rheumatoid arthritis. The study was published May 22 online in advance of publication in the journal Nature Immunology.

"Prior to this study, TNF has long been known as a potent pro-inflammatory cytokine, but if you look carefully through the literature, there are hints that it also has some suppressive functions, but nothing was known about the mechanisms," said Lionel Ivashkiv, M.D., associate chief scientific officer and physician in the Arthritis and Tissue Degeneration Program at Hospital for Special Surgery who led the study. "This is really the first mechanism showing how TNF can turn inflammation down."

Because many proteins have homeostatic functions, both driving and suppressing certain actions so a cell can maintain internal equilibrium, researchers thought TNF might not be an exception. "Most strong activators in the immune system trigger a feedback response to restrain the amount of inflammation," Dr. Ivashkiv said.

To find out, researchers designed experiments stimulating macrophages with lipopolysaccharide (LPS), a prototypical inflammatory factor that stimulates receptors important in inflammation. In test tube studies, the researchers treated human monocytes and macrophages, cells that have a key role in inflammatory diseases, with TNF and then challenged these cells with LPS. They found that the TNF suppressed the inflammatory response of the macrophages and monocytes. They then gave mice low doses of TNF followed by high doses of LPS and found that the mice were protected from the effects of high dose LPS, which is usually lethal. They discovered that the mechanism by which TNF
'/>"/>

Contact: Phyllis Fisher
phyllis.fisher@gmail.com
212-606-1197
Hospital for Special Surgery
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related medicine news :

1. Despite Treatment, Employees with Depression Generate Higher Absentee Costs, According to Thomson Reuters Study
2. American Council on Exercise (ACE) Study Reveals Kettlebells Provide Powerful Workout in Short Amount of Time
3. TV drama can be more persuasive than news program, study finds
4. Study carried out into biological risks of eating reptiles
5. Neuroimaging study may pave way for effective Alzheimers treatments
6. Study finds racial gaps continue in heart disease awareness
7. Luth Researchs IndicatorEDG(TM) Study Finds Americans Hopes of Achieving Their Dreams Are Fading
8. First blinded study of venous insufficiency prevalence in MS shows promising results
9. Soothing infants with food focus of childhood obesity study
10. People with anxiety disorder less able to regulate response to negative emotions, study shows
11. American Heart Association Rapid Access Journal Report: Study Finds Racial Gaps Continue in Heart Disease Awareness, Low Knowledge of Heart Attack Warning Signs Among Women
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/19/2013)... STRATFORD, Conn (PRWEB) June 20, 2013 A man ... same man he used to be. In his debut book titled ... a war veteran who immerses himself back home, looking for the ... When Gabriel De Los Angeles, former marine from the Vietnam War, ... to take the edge off his PTSD. Wings, a wealthy acquaintance ...
(Date:6/19/2013)... Across the globe billions of people live ... the medical advances that benefit developed western society. ... and the necessary aid to help curb the conditions ... Outlook with Ben Kingsley is partnering with some ... these people live and highlight the invaluable resources being ...
(Date:6/19/2013)... 2013 HASCO Medical, Inc. (OTCBB: ... intent to purchase privately held Auto Mobility Sales, ... wheelchair accessible vehicle sales, service and rentals in ... Inc compliments and expands HASCO's strategy of becoming ... dealers . The acquisition is subject to customary ...
(Date:6/19/2013)... 2013 Kleritec, Inc. announced the addition ... http://www.kleritec.com . In the recent expansion Kleritec ... activities packages for pre-school and day care providers. The ... to aid teachers across the United States the ability ... , Included in the art and activities packages is ...
(Date:6/19/2013)... Citi Bike has come to New York City in ... to know for sure how many patients will choose to take ... the option. In fact, he’s happy about anything that might ... it more convenient for them to visit his office at 133 ... Alternative Medicine at Back and Body Medical and an experienced ...
Breaking Medicine News(10 mins):Health News:Rafael Fragauda’s New Book Underlines Post Traumatic Stress Disorder 2Health News:HASCO Medical, Inc. to Acquire Auto Mobility Sales, Inc. 2Health News:Kleritec Announces Addition of Educational Products. 2Health News:New York City's Back and Body Medical Welcomes Citi Bike to Midtown Manhattan 2Health News:New York City's Back and Body Medical Welcomes Citi Bike to Midtown Manhattan 3
... Cuts Will Reduce Access to Care for Millions ... , , ARLINGTON, Va., Sept. 16 ... recommendations for healthcare reform in his long-awaited "Chairman,s mark" version of ... home medical equipment, ranging from power wheelchairs to anti-fraud measures. The ...
... strong disapproval of contraception might be a factor , ... are higher in states with greater levels of religious ... new U.S. study suggests. , In the study, researchers ... on teen birth rates with data from the Pew ...
... , PANAMA CITY, Fla., Sept. 16 ... staff washing their hands when moving from patient to patient can ... Commission , handwashing failures contribute to healthcare-associated infections ... hospitals $4 billion to $29 billion annually to combat. At ...
... , MINNEAPOLIS, Sept. 16 Today ClearWay ... and thanked outgoing members for their service to the organization. David ... as the new Board Chair. The full roster of Board Officers ... David Fisher, Board Chair - An attorney ...
... , , , SAN DIEGO, ... Diego based medical device company, today announced that its application for ... technology has been approved by the Food and Drug Administration. The ... , , Jim Hitchin, SpectraScience,s, CEO said, ...
... InVitria to ... in Animal Cells (PEACe) in Jackson Hole, WY, Sept. 19-23. , ... Fort Collins, CO (PRWEB) September 16, 2009 -- InVitria ... supplements at the 9th Annual PEACe conference to be held in Jackson Hole, WY, Sept. ...
Cached Medicine News:Health News:Senate Finance Committee Cuts Home Medical Equipment in Reform Package 2Health News:Bay Medical Fights Healthcare-Associated Infections by Improving Hand Hygiene 300% 2Health News:Bay Medical Fights Healthcare-Associated Infections by Improving Hand Hygiene 300% 3Health News:Bay Medical Fights Healthcare-Associated Infections by Improving Hand Hygiene 300% 4Health News:ClearWay Minnesota(SM) Board Approves New Officers 2Health News:SpectraScience Receives FDA Approval for Enhancements to WavSTAT(R) Optical Biopsy System 2Health News:InVitria Cell Culture Product Line to Headline PEACe 2
(Date:6/19/2013)... OAKS, Calif. , June 19, 2013 Amgen ... the United States , Canada ... this year,s recipients of the Amgen Award for Science Teaching ... extraordinary teachers at the kindergarten through 12th grade level who ... in science education. With a long-standing commitment to ...
(Date:6/19/2013)... Pharmacyclics, Inc. (the "Company") (Nasdaq: ... Journal of Medicine ( NEJM ) published results ... oral Bruton,s tyrosine kinase (BTK) inhibitor ibrutinib in patients ... lymphoma (SLL). Ibrutinib was shown to be safe and ... in patients who were at high-risk due to factors ...
(Date:6/19/2013)...   NextDocs announced today that it will ... at DIA 2013 , the Drug Information Association ... studies that explore best practices for making the transition ... file (eTMF) systems. Sharon Ames , ... Krystyna Kowalczyk , executive vice president of clinical operations ...
Breaking Medicine Technology:Amgen Award For Science Teaching Excellence Honors Outstanding Teachers 2Amgen Award For Science Teaching Excellence Honors Outstanding Teachers 3Ibrutinib Study Results in Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia Published in The New England Journal of Medicine 2Ibrutinib Study Results in Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia Published in The New England Journal of Medicine 3Ibrutinib Study Results in Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia Published in The New England Journal of Medicine 4Ibrutinib Study Results in Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia Published in The New England Journal of Medicine 5Ibrutinib Study Results in Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia Published in The New England Journal of Medicine 6NextDocs and Novella to Present on eTMF at DIA 2013 2
... 1 Block MBS Start up kit. ... software and choice of 1 MultiBlock ... to 30 blocks. User friendly software. ... Adjustable height heated lid. Outstanding ...
0.2ml Gradient Block MBSR. Robot compatible block ejection mechanism. Stackable. (96 well block - holds 1 plate 0.2ml x 96 well plate)...
96 well format, Gradient features tests 12 PCR annealing temperatures in 1 run...
... The latest addition to our ... cyclers is the personal-sized GeneAmp ... instrument for both basic PCR ... represents the culmination of several ...
Medicine Products: