Navigation Links
Study identifies new risk factor for heart disease among kidney dialysis patients
Date:3/6/2013

would normally be metabolized, they become attracted to atherosclerotic plaques which can lead to the development of atherosclerosis or hardening of the arteries."

Knowing that there is growing evidence that urea and protein carbamylation are important contributors to the risk of heart disease and death in patients with kidney failure, Berg and his collaborators hypothesized that measurements of carbamylated albumin the most abundant protein in the blood --could provide an index of patients' blood urea concentrations and could be used in a blood test to provide clinicians with information on how well dialysis treatments are working to remove body waste products from patients with kidney failure.

As predicted, in two independent clinical experiments, the investigators demonstrated that increased carbamylated albumin is strongly associated with an elevated risk of premature death in patients on dialysis. They additionally found that increased carbamylated albumin in dialysis patients was linked with low blood concentrations of amino acids, the building blocks of proteins.

"This suggests that amino acid deficiencies may contribute to increased protein carbamylation in dialysis patients," says Berg. "In separate experiments in both cells and in mice, we found that amino acids act as carbamylation scavengers, competitively inhibiting protein carbamylation."

The researchers were able to generate their findings through a variety of complex studies, including protein screening experiments to search for sites of carbamylation on albumin and observational studies in which they first measured albumin carbamylation in blood samples from patients with kidney disease and then followed the patients to determine whether the extent of carbamylation correlated with risk of premature death. The investigators also measured blood concentrations of amino acids in 187 patients to determine if amino acid deficiencies were linked with increased prote
'/>"/>

Contact: Bonnie Prescott
bprescot@bidmc.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Study Suggests Vaccine May Help Kids With Brain Cancer
2. Study reveals how cancer drug causes diabetic-like state
3. Coffee Drinking in Pregnancy Wont Lead to Sleepless Baby: Study
4. Lower GI problems plague many with rheumatoid arthritis, Mayo Clinic study finds
5. Veggies Like Broccoli, Cabbage May Help Fight Breast Cancer: Study
6. No Added Cancer Risk From Hip Replacement Materials: Study
7. Reported Decline in U.S. Pneumonia Deaths May Be False: Study
8. Early Study Finds Some Promise for Lung Cancer Vaccine
9. Narcissists Often Ace Job Interviews, Study Finds
10. Sexual objectification of female artists in music videos exists regardless of race, MU study finds
11. Soy may alleviate hot flashes in menopause, large-scale study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... Dentists from throughout Canada tomorrow will ... Oxnard All-on-4™ dental implants expert and world-renowned ... Anacapa Dental Art Institute in Ventura County, Calif., ... Restorative Dentistry and Prosthodontics (CARDP) annual Scientific Meeting ... Augmentation: Esthetic Implant Supported Maxillary Prostheses,” is scheduled ...
(Date:9/18/2014)... Forty Fort, PA (PRWEB) September 18, 2014 ... remodeling display at the Bloomsburg Fair beginning this Saturday. ... The display is a great example of the products and ... three cabinet lines and various countertops for fair-goers to see. ... Home & Garden Show earlier this year and really is ...
(Date:9/18/2014)... 18, 2014 New discount dental plans ... find dentists and see exact plan savings in their area ... and have an immediate ID# to use the plan same ... there choosing the right plan can be difficult. With most ... exact plan savings and discounts in a particular zip code ...
(Date:9/18/2014)... NY (PRWEB) September 18, 2014 Computer ... solutions firm based in New York City, has been ... for a leading global retailer with stores in over ... central help desk with CRA being the retailer’s dispatch ... NYC office. , Chico Ramnarayan, Chief Executive Officer of ...
(Date:9/18/2014)... Columbia, SC (PRWEB) September 18, 2014 ... has just launched a new website which will make ... an accident in South Carolina to find helpful information ... office can provide to families of accident victims. , ... offers an improved mobile experience for today’s digital consumers. ...
Breaking Medicine News(10 mins):Health News:Oxnard All-on-4™ Dental Implants Expert To Speak Tomorrow at Prestigious Canadian Academy of Restorative 2Health News:Oxnard All-on-4™ Dental Implants Expert To Speak Tomorrow at Prestigious Canadian Academy of Restorative 3Health News:Oxnard All-on-4™ Dental Implants Expert To Speak Tomorrow at Prestigious Canadian Academy of Restorative 4Health News:Oxnard All-on-4™ Dental Implants Expert To Speak Tomorrow at Prestigious Canadian Academy of Restorative 5Health News:One Week Kitchens Taking Display to Bloomsburg Fair 2Health News:Discount Dental Plans Allow Consumers to Search Thousands of Local Dentists, Compare Savings and Discounts, and Download a Printable Membership Card 2Health News:CRA Awarded Managed Support Contract for Global Retailer 2Health News:Columbia Personal Injury Law Firm Announces Launch of Redesigned Website 2
... ,Extended synaptic development may explain why humans are intellectually superior ... few years of life, human babies, mental abilities continue to ... a way that far surpasses even the closest primate relatives ... according to the study published online Feb. 1 in the ...
... breast cancer cell proliferation in a randomized clinical trial, ... Research , a journal of the American Association for ... professor of surgery at the Robert H. Lurie Comprehensive ... this study are consistent with the findings of previous ...
... Madonna Behen HealthDay Reporter , THURSDAY, Feb. 2 ... can help lower the risk of stroke, but a new ... better odds of recovery if they do suffer a stroke. ... physically active before a stroke responded much better to clot-busting ...
... aged 70 and over will increase by 40% in ... over will more than double1. Health authorities and the ... of people suffering costly and debilitating age-related chronic diseases ... dementia. The significant increase in the numbers of people ...
... By Margaret Farley Steele and Steven Reinberg ... disease appears to spread through the brain, traveling from neuron ... or cancer moves through the body, new research with mice ... that abnormal tau protein -- already identified in the brains ...
... 2012 Postmenopausal women may be at higher risk of ... study by researchers at NYU Langone Medical Center and colleagues ... high cholesterol are not as accurate at predicting risk ... should refocus their attention on triglyceride levels to determine which ...
Cached Medicine News:Health News:Why Human Brains Are Smarter Than Chimp Brains 2Health News:Being Fit Before Stroke May Aid Recovery 2Health News:Being Fit Before Stroke May Aid Recovery 3Health News:New study to assess 3 simple, cost-effective strategies to promote healthy aging 2Health News:Mouse Study Suggests Alzheimer's Spreads Through Brain Like an Infection 2Health News:Mouse Study Suggests Alzheimer's Spreads Through Brain Like an Infection 3Health News:Triglyceride levels predict stroke risk in postmenopausal women 2
(Date:9/17/2014)... , September 17, 2014 ... GRC 17536, has shown positive data in a Phase ... diabetic neuropathy , Glenmark Pharmaceuticals ... Potential Ankyrin 1 (TRPA1) antagonist, GRC 17536 has shown ... controlled, multi-centre, proof of concept study conducted on 138 ...
(Date:9/17/2014)... , Sept. 17, 2014  Lightbeam Health ... Accountable Care Organization (Physician Direct ACO) to deploy ... physicians in providing better care while reducing costs. ... Physician Direct Accountable Care Organization is ... Services (OPNS). The OPNS mission is to be ...
(Date:9/17/2014)... According to a new market ... Memory Device, Display, & Microprocessor/MCU), by Application (Imaging, Medical ... Geography - Global Forecast to 2020", published by MarketsandMarkets, ... to reach $56.50 Billion by 2020, growing at a ... Browse 235 market data Tables and 71 Figures spread ...
Breaking Medicine Technology:Glenmark's TRPA1 Antagonist 'GRC 17536' Shows Positive Data in a Proof of Concept Study 2Glenmark's TRPA1 Antagonist 'GRC 17536' Shows Positive Data in a Proof of Concept Study 3Physician Direct Accountable Care Organization Selects Lightbeam Health to Enable Better Care at a Lower Cost 2Physician Direct Accountable Care Organization Selects Lightbeam Health to Enable Better Care at a Lower Cost 3Medical Electronics Market Worth $56.50 Billion by 2020 2Medical Electronics Market Worth $56.50 Billion by 2020 3Medical Electronics Market Worth $56.50 Billion by 2020 4
... Alliance Catheter Delivery System (CDS) ... stabilization of the Aescula LV ... has a patented coronary sinus ... and easy access to the ...
... PCS2 system is Haemonetics ... collection of plasma and ... the collection of "jumbo" ... platelet-poor plasma with optional ...
Optipress II Automated Blood Component Extractor for the standardized separation of whole blood into high purity individual components...
... Pipette* provides quick, convenient, repetitive dispensing ... Combitips have a polyethylene plunger and ... for use with most reagents. ... Five separate volumes can be selected ...
Medicine Products: