Navigation Links
Study identifies mechanism underlying multidrug resistance in fungi
Date:4/2/2008

patients with compromised immunity, says Nr, an assistant professor of Cell Biology at Harvard Medical School (HMS).

The researchers also found exactly how Pdr1p turns on the multidrug resistance program. After binding to drugs, the Pdr1p protein partners with another key mediator of genetic switches called Gal11p. In-depth molecular and structural studies in collaboration with the team of co-author Gerhard Wagner, PhD, Elkan Blout Professor of Biological Chemistry and Molecular Pharmacology at HMS identified the specific area of Gal11p that binds to Pdr1p to induce multidrug resistance.

This detailed understanding of the interaction between these proteins will allow screening for small-molecule inhibitors of protein binding. Such inhibitors may lead to novel co-therapeutics that will sensitize multidrug-resistant fungal infections to standard antifungal therapy, says Wagner.

To further investigate the relevance of their findings, the researchers used a C. elegans roundworm model system recently developed by co-author Eleftherios Mylonakis, MD, PhD, of MGH Infectious Disease to study fungal pathogens. They found that worms infected with Candida glabrata that lacked either the Pdr1p or Gal11p proteins could be successfully treated with typical antifungal medications, suggesting that targeting the gene switch controlled by those proteins interaction could restore the effectiveness of standard drugs.

Fungal infections have a serious impact on immunocompromised patients, and the development of resistance is particularly worrisome, since targets for antifungal drugs are limited, says Mylonakis, an assistant professor of Medicine at HMS. Given these concerns, having the opportunity to use our model system for the in vivo investigation of this resistance mechanism has been a particularly fulfilling endeavor.


'/>"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Overweight kids have fewer cavities, new study shows
2. Families of children with cancer support human tissue research, study finds
3. Study Finds Older Corneas Suitable for Transplantation
4. ExoSeal vascular plug gets good reviews in ECLIPSE study
5. Iso-osmolar X-ray dye falters in PCI study
6. SEISMIC study issues glum report on cell therapy
7. Dallas area cornea shortages could benefit from national study
8. Humans have more distinctive hearing than animals, Hebrew U study shows
9. Drug use increasingly glamorized in rap music, according to new study of 2-decade trends
10. New study finds glamorization of drugs in rap music jumped dramatically over 2 decades
11. Indiana University study finds majority of US physicians favor national health insurance
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/1/2014)... Nordic Naturals is kicking off ... cause. The campaign—“Buy One Bottle. Help Two Heroes.”—will ... a nonprofit organization that helps rebuild the lives ... that would otherwise face euthanasia. From October through ... monthly donations of Nordic Naturals omega-3s to veterans ...
(Date:10/1/2014)... Deland, Florida (PRWEB) October 01, 2014 ... to promote awareness and early detection plans while raising ... to support Breast Cancer Awareness Month in ... Water also wants to promote the importance of having ... contaminated drinking water may be linked to certain forms ...
(Date:10/1/2014)... CA (PRWEB) October 01, 2014 ... will speak to a group of dental specialists who ... the northern Spain city of Oviedo. Dr. Reshad of ... and lecturer with clients on two continents, will give ... and aesthetic full mouth reconstruction. , “These specialists want ...
(Date:10/1/2014)... 2014 Dr. Saj Jivraj, one of ... is traveling to Chennai, India, tomorrow to speak at ... and 3. , Dr. Jivraj is founder of the ... Calif., and one of the world’s foremost prosthodontists, meaning ... He is speaking to the Indian Society of Oral ...
(Date:10/1/2014)... October 01, 2014 Today marks the ... Dental Art Institute in Oxnard and Woodland Hills, Calif., ... full mouth rehabilitation training. , “Speaking to this group ... transformative procedures to get the help and care they ... involve repairing previous dental work, providing cosmetic dentistry, correcting ...
Breaking Medicine News(10 mins):Health News:Nordic Naturals® Inspires Support for Paws for Veterans -- ‘Buy One Bottle. Help Two Heroes.’ Initiative Kicks Off October 1 2Health News:Pelican Water Supports Breast Cancer Awareness Month with Order Donations 2Health News:Woodland Hills Dental Implants Expert Training Dental Specialists in Spain Later This Week 2Health News:Woodland Hills Dental Implants Expert Training Dental Specialists in Spain Later This Week 3Health News:Woodland Hills Dental Implants Expert Training Dental Specialists in Spain Later This Week 4Health News:One of Woodland Hills’ Top Cosmetic Dentists Speaking to Indian Society of Oral Implantologists Tomorrow 2Health News:One of Woodland Hills’ Top Cosmetic Dentists Speaking to Indian Society of Oral Implantologists Tomorrow 3Health News:One of Woodland Hills’ Top Cosmetic Dentists Speaking to Indian Society of Oral Implantologists Tomorrow 4Health News:One of Woodland Hills’ Top Cosmetic Dentists Speaking to Indian Society of Oral Implantologists Tomorrow 5Health News:Internationally Respected Oxnard Dentist Concludes All-on-4™ Dental Implants Training Today 2Health News:Internationally Respected Oxnard Dentist Concludes All-on-4™ Dental Implants Training Today 3Health News:Internationally Respected Oxnard Dentist Concludes All-on-4™ Dental Implants Training Today 4Health News:Internationally Respected Oxnard Dentist Concludes All-on-4™ Dental Implants Training Today 5
... neck pain by spine manipulation appears of little use as ... in the UK to relieve many different types of pain,// ... ,When 16 studies were reviewed it was concluded ... is effective for treating any medical problem. ...
... member of the parliament belonging to the Papua New Guinea parliament ... virus//. He will be the first person in the country to ... unnamed MP could be jailed under a 2003 law that made ... Nation newspaper in Papua New Guinea reported. ,The paper ...
... became known that they had cheated the Medicare by more ... were not mandated and hence was never conducted. ... of the illegal scheme from 1997 to 2005. He and ... beneficiaries and introducing them to several doctor’s and medical labs ...
... (FSA), that the daily intake of salt should be limited to ... mention the amount of salt content in their food labels. A ... either side. ,A public awareness watchdog for Foodstuffs set ... salt in a lot of food products. This is done for ...
... common man that how official failings led to a man ... history of violence. Stuart Robertson was killed by James Smith, ... in October 2004. This report mainly gives us an insight ... , There was a failure to respond adequately ...
... the first of its kinds study conducted by the ... Communications Research (CECCR) found// that Women suffering from breast ... given the opportunity to participate in online support groups. ... to ,openly express themselves trying to make sense of ...
Cached Medicine News:Health News:Research demystifies treatment by manipulation of spine by chiropractors in the UK 2Health News:Salt & Its Intake Causes a Strong debate In UK 2Health News:Study Finds Online Support Groups Emotionally Benefit Women Suffering From 2
(Date:9/30/2014)... -- MiMedx Group, Inc. (NASDAQ: MDXG ), ... and patent-protected processes to develop and market advanced products ... Sports Medicine, Ophthalmic and Dental sectors of healthcare, announced ... Officer, will present at the Stem Cell Meeting on ... 7, 2014, at 5:00PM Pacific Daylight Time. ...
(Date:9/30/2014)... 2014 Arbor Pharmaceuticals, LLC. - Product ... Markets Direct,s, ,Arbor Pharmaceuticals, LLC. - Product Pipeline ... Arbor Pharmaceuticals, LLC.,s pharmaceutical research and development focus. ... current therapeutic developmental pipeline of Arbor Pharmaceuticals, LLC.,s, ... assessment by drug target, mechanism of action (MoA), ...
(Date:9/30/2014)... Sept. 30, 2014  According to their CEO, ... cancer clinical trials is going through a complete ... the work of the current clinical trial management ... ,next generation, clinical trials, which will ultimately drive ... The company has been recognized by the ...
Breaking Medicine Technology:MiMedx to Present at the Stem Cell Meeting on the Mesa 2Arbor Pharmaceuticals, LLC. - Product Pipeline Review - 2014 2Arbor Pharmaceuticals, LLC. - Product Pipeline Review - 2014 3Small Denver Company Pharmatech driving a large revolution in how cancer clinical trials are managed 2
... Today GenVec, Inc. (Nasdaq: GNVC ) announced financial ... 2010.  For the year ended December 31, 2010, the Company ... share, compared with a net loss of $18.4 million, or ... GenVec ended the year with $35.2 million in cash, cash ...
... RIVER EDGE, N.J., March 10, 2011 Nephros, Inc. ... device company developing and marketing filtration products for therapeutic ... completion of its rights offering and private placement that ... to Nephros.  The aggregate net proceeds received by Nephros ...
Cached Medicine Technology:GenVec Reports Fourth Quarter and 2010 Year-End Financial Results 2GenVec Reports Fourth Quarter and 2010 Year-End Financial Results 3GenVec Reports Fourth Quarter and 2010 Year-End Financial Results 4GenVec Reports Fourth Quarter and 2010 Year-End Financial Results 5GenVec Reports Fourth Quarter and 2010 Year-End Financial Results 6GenVec Reports Fourth Quarter and 2010 Year-End Financial Results 7GenVec Reports Fourth Quarter and 2010 Year-End Financial Results 8Nephros Announces Completion of $3.2 Million Financing Through Rights Offering and Private Placement Transactions 2Nephros Announces Completion of $3.2 Million Financing Through Rights Offering and Private Placement Transactions 3Nephros Announces Completion of $3.2 Million Financing Through Rights Offering and Private Placement Transactions 4
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: