Navigation Links
Study identifies mechanism underlying multidrug resistance in fungi
Date:4/2/2008

patients with compromised immunity, says Nr, an assistant professor of Cell Biology at Harvard Medical School (HMS).

The researchers also found exactly how Pdr1p turns on the multidrug resistance program. After binding to drugs, the Pdr1p protein partners with another key mediator of genetic switches called Gal11p. In-depth molecular and structural studies in collaboration with the team of co-author Gerhard Wagner, PhD, Elkan Blout Professor of Biological Chemistry and Molecular Pharmacology at HMS identified the specific area of Gal11p that binds to Pdr1p to induce multidrug resistance.

This detailed understanding of the interaction between these proteins will allow screening for small-molecule inhibitors of protein binding. Such inhibitors may lead to novel co-therapeutics that will sensitize multidrug-resistant fungal infections to standard antifungal therapy, says Wagner.

To further investigate the relevance of their findings, the researchers used a C. elegans roundworm model system recently developed by co-author Eleftherios Mylonakis, MD, PhD, of MGH Infectious Disease to study fungal pathogens. They found that worms infected with Candida glabrata that lacked either the Pdr1p or Gal11p proteins could be successfully treated with typical antifungal medications, suggesting that targeting the gene switch controlled by those proteins interaction could restore the effectiveness of standard drugs.

Fungal infections have a serious impact on immunocompromised patients, and the development of resistance is particularly worrisome, since targets for antifungal drugs are limited, says Mylonakis, an assistant professor of Medicine at HMS. Given these concerns, having the opportunity to use our model system for the in vivo investigation of this resistance mechanism has been a particularly fulfilling endeavor.


'/>"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Overweight kids have fewer cavities, new study shows
2. Families of children with cancer support human tissue research, study finds
3. Study Finds Older Corneas Suitable for Transplantation
4. ExoSeal vascular plug gets good reviews in ECLIPSE study
5. Iso-osmolar X-ray dye falters in PCI study
6. SEISMIC study issues glum report on cell therapy
7. Dallas area cornea shortages could benefit from national study
8. Humans have more distinctive hearing than animals, Hebrew U study shows
9. Drug use increasingly glamorized in rap music, according to new study of 2-decade trends
10. New study finds glamorization of drugs in rap music jumped dramatically over 2 decades
11. Indiana University study finds majority of US physicians favor national health insurance
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/12/2014)... 2014 Sean Francis, owner of the Kawartha Lakes ... to his clients. He’s also known for his support of local ... way to combine the two and is excited to announce that ... Boys and Girls Club. , The funds are the result of ... 23rd. Francis sent out emails and asked his clients to put ...
(Date:7/12/2014)... PA (PRWEB) July 12, 2014 “After my mom’s ... then had a stroke and loss the use of his left ... to design a way to help people like them enjoy eating ... created a prototype for the PATRICIA CAROL HALL PLATE (P C ... PLATE) offers a more ergonomic way to eat for individuals who ...
(Date:7/12/2014)... 12, 2014 Using and carrying around ... two inventors from Ashland, Va., decided that there needed ... inspired us to conceive of our design," he said. ... KIDNEY KOVER, which provides an inconspicuous way to use ... as well as promotes comfort and peace of mind. ...
(Date:7/12/2014)... York (PRWEB) July 12, 2014 As ... move forward in U.S. courts, Bernstein Liebhard LLP notes ... metal ion levels to the failure of metal-on-metal hip ... issue of The Journal of Bone & Joint Surgery, ... unilateral Articular Surface Replacement prostheses at least twelve months ...
(Date:7/12/2014)... July 12, 2014 With prom shopping ... manufacturer and retailer, is ready to showcase its new ... new collection of evening dresses in its online shop. ... 67% off) for these elegant gowns. According to the ... end on July 26, 2014. , He says, ...
Breaking Medicine News(10 mins):Health News:Kawartha Lakes Fit Body Boot Camp’s Successful Fat Loss Challenge Results in $2,000 to Boys and Girls Club 2Health News:Kawartha Lakes Fit Body Boot Camp’s Successful Fat Loss Challenge Results in $2,000 to Boys and Girls Club 3Health News:DePuy Pinnacle Hip Lawsuit News: Bernstein Liebhard LLP Notes Release of New Study Tying Elevated Metal Ions to Metal-on-Metal Hip Failure 2Health News:DePuy Pinnacle Hip Lawsuit News: Bernstein Liebhard LLP Notes Release of New Study Tying Elevated Metal Ions to Metal-on-Metal Hip Failure 3Health News:DePuy Pinnacle Hip Lawsuit News: Bernstein Liebhard LLP Notes Release of New Study Tying Elevated Metal Ions to Metal-on-Metal Hip Failure 4Health News:VogueQueen.com Updates Its Summer Collection With New And Trendy Evening Dresses 2
... study finds that traditional Chinese medical beliefs continue to ... ,Jacqueline Hom, a dental student at the ... her findings today during the 85th General Session of ... a two-month period, she gathered ethnographic data from 67 ...
... hours of junior doctors' has been reduced in order to ... enquired 1,400 medics found that cutting down working hours alone ... the design of rotas was essential. ,The Occupational ... Massey and Auckland universities in New Zealand. ,In ...
... recently announced that Beijing is looking into possibilities of ... further encourage foreign investments the government is allowing companies ... the private medical facility. ,At a press ... will be strictly supervised by the Chinese government but ...
... testing saliva samples, U.S. researchers have// found. ... the General Dentistry, a journal of the Academy of ... potential to assist in the diagnosis, treatment, and follow-up ... testing has some advantages over blood testing. Saliva is ...
... (UAE) is analysing its HIV/AIDS policies to develop a ... reported Thursday., ,Officials from governmental agencies as ... UNAIDS and UNDP, discussed the HIV/AIDS situation in the ... the first of many steps needed to formulate a ...
... for Science in the Public Interest, says not much has changed ... still unhealthy. ,According to the report, a plate of ... more sodium and more than half the calories an average adult ... dish with vegetables has 1,300 calories, 3,200 milligrams of sodium and ...
Cached Medicine News:Health News:Rest for Doctors to Ensure Patients’ Safet 2Health News:Chinese-food Lovers, Beware 2
(Date:7/11/2014)... 2014 /PRNewswire-iReach/ -- VAPETEK™, Inc. has announced a ... use in portable vaporizers, which contains CBD, or ... cannabis, cannabidiol offers consumers a THC-free product made ... vaporizer technology. Photo - http://photos.prnewswire.com/prnh/20140711/126344 ... different compounds which are currently known, two of ...
(Date:7/11/2014)... 11, 2014 Patient engagement has become ... organizations are turning to an assortment of marketing ... part of this evolving approach to patient engagement, ... and engage patients throughout their experiences with a ... By mapping the patient journey and employing a ...
(Date:7/11/2014)... , July 11, 2014 The ... are evolving across industry sectors to better identify ... better ways to engage with and understand consumers, ... themselves and make critical purchasing decisions. ... Best Practices, LLC, one area where organizations can ...
Breaking Medicine Technology:VAPETEK Releases CBD-Infused eLiquid For The Consumer Market 2New Study Uses Six-Step Patient Journey as Framework for Consumer-Focused Marketing Opportunities 2New Technologies Transforming Consumer Marketing Research Playbook 2
... UBM Canon today announced medical manufacturing event plans ... respectively its long established MEDTEC and Medical Design & ... MEDTEC India Conference & Exhibition will debut in ... suppliers. The event will deliver the latest in best ...
... YORK, Dec. 14, 2010 Reportlinker.com announces that a ... U.S. Market for Patient Monitoring Devices ... In 2010, the U.S. patient monitoring market was ... 2009. The market for patient ...
Cached Medicine Technology:UBM Canon Launches Medical Manufacturing Events in India and Brazil 2Reportlinker Adds U.S. Market for Patient Monitoring Devices 2011 2Reportlinker Adds U.S. Market for Patient Monitoring Devices 2011 3Reportlinker Adds U.S. Market for Patient Monitoring Devices 2011 4Reportlinker Adds U.S. Market for Patient Monitoring Devices 2011 5Reportlinker Adds U.S. Market for Patient Monitoring Devices 2011 6Reportlinker Adds U.S. Market for Patient Monitoring Devices 2011 7Reportlinker Adds U.S. Market for Patient Monitoring Devices 2011 8Reportlinker Adds U.S. Market for Patient Monitoring Devices 2011 9Reportlinker Adds U.S. Market for Patient Monitoring Devices 2011 10Reportlinker Adds U.S. Market for Patient Monitoring Devices 2011 11Reportlinker Adds U.S. Market for Patient Monitoring Devices 2011 12Reportlinker Adds U.S. Market for Patient Monitoring Devices 2011 13Reportlinker Adds U.S. Market for Patient Monitoring Devices 2011 14Reportlinker Adds U.S. Market for Patient Monitoring Devices 2011 15Reportlinker Adds U.S. Market for Patient Monitoring Devices 2011 16Reportlinker Adds U.S. Market for Patient Monitoring Devices 2011 17Reportlinker Adds U.S. Market for Patient Monitoring Devices 2011 18Reportlinker Adds U.S. Market for Patient Monitoring Devices 2011 19Reportlinker Adds U.S. Market for Patient Monitoring Devices 2011 20
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: