Navigation Links
Study identifies key player in the body's immune response to chronic stress
Date:9/3/2007

ncreased rates of infection after flight. Through an animal study, Shi and colleagues simulated spaceflight conditions to investigate its effects on the immune system. They found that infection-fighting white blood cells inappropriately die off in large numbers, leading to immune-organ atrophy and the decreased ability of the immune system to protect the body from illness.

The team studied two types of mice, one group with the normal OPN gene and another group lacking this gene. The mice experienced three days of hindlimb unloading, a widely used technique to simulate the physiologic changes that astronauts experience during spaceflight. With this technique, body fluids shift similarly to how they do in microgravity (toward the head instead of toward the extremities) and immune system changes occur.

Mice of both types made up the control groups, which did not undergo unloading.

After three days, the researchers compared the mice with normal OPN and the OPN-lacking mice. The normal OPN mice experienced weight loss, spleen and thymus atrophy, and a reduced number of white blood cells. In addition, increased levels of corticosterone, a steroid that contributes to the death of white blood cells, were found only in the normal OPN mice studied.

By contrast, the mice lacking the OPN gene showed statistically insignificant changes in weight and the levels of corticosterone, and were more similar to the control group.

White blood cell death in the spleen and thymus was evident only in the mice with normal OPN, Shi said. Since white blood cells were dying rather than increasing, that indicates partly why immune system organs atrophy during prolonged physical stress.

The team concluded that under chronic physical stress, OPN must be present for the increase in corticosterone, which leads to atrophy and white blood cell death.

Shi hopes that this finding will lead to preventative treatments in the future.'/>"/>

Contact: Lauren Hammit
lhammit@bcm.edu
713-798-7595
National Space Biomedical Research Institute
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Gene study links endometriosis, infertility
2. Study reveals how stress can make you sick
3. Study points out that HIV vaccine may not be accepted easily
4. A new study surpasses Gene Therapy Hurdle
5. Tomato Sauce reduces Cancer Risk- Study
6. A question on study of Adult Stem Cell
7. Study on obesity and heart failure
8. National Lung Study in the process
9. Marijuana gateway theory strengthened by study of twins
10. Old theory of adaptation confirmed by new study
11. Study casts doubt on keyboard ills
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2015)... 2015 Coordinating care for people ... Historically providers have not been reimbursed or rewarded ... 2015, Medicare has paved the way by offering ... the launch of Oculus Health , an ... using the platform will now be able to ...
(Date:5/22/2015)... May 22, 2015 Power Systems is proud ... the 2015 race season. Drobeck is in his second year ... a firefighter with the Missoula Fire Department in Missoula, MT. ... Pro in 2014. During his career, he has had 15 ... Drobeck recorded top 10 finishes in all seven of his ...
(Date:5/22/2015)... According to Berks and Beyond , ... death, totaling almost 2,500 confirmed drug deaths, as reported on ... totals 2,489 deaths stemming from legal and illegal drug use ... people every day to fatal overdoses or other drug related ... one of the most rife with drug related deaths. The ...
(Date:5/22/2015)... (PRWEB) May 22, 2015 Medivo, Inc., a ... “Positivity Rates and Genotype Results in ‘Baby Boomers’ Screened for ... a Nationwide Lab Test Database” at Digestive Disease Week, May ... Clinical Affairs and Analytics team members Carol Smyth, MB; Jason ... Andrea Parker, MSI, along with Nancy Reau, MD from the ...
(Date:5/22/2015)... 2015 Wimbledon Health Partners, the leading ... echocardiogram and NCV testing , is proud to ... All American National athlete, to the Wimbledon Athletics division. ... high level of testing and information it provides to ... athletic trainers, this way they can focus on the ...
Breaking Medicine News(10 mins):Health News:Oculus Health Care Coordination Platform Officially Launched 2Health News:Oculus Health Care Coordination Platform Officially Launched 3Health News:Oculus Health Care Coordination Platform Officially Launched 4Health News:Philadelphia Ranks Among the Tops Cities in Penn. for Drug Deaths 2Health News:Medivo Study Finds HCV Positivity Rates are 250% Higher Among Baby Boomers 2Health News:Wimbledon Athletics Recruits Team USA Athlete 2Health News:Wimbledon Athletics Recruits Team USA Athlete 3
... This release is available in Spanish . ... Navarra have revealed the existence of genetic variants that have ... of the pharmaceutical drug in some child patients affected by ... order to obtain a personalised therapeutic treatment in the future. ...
... International Osteoporosis Foundation (IOF) invites clinicians and researchers ... a joint meeting to be held from March ... participants are expected at the four-day meeting which ... as a broad spectrum of clinically-oriented ,Meet-the-Professor, sessions. ...
... , The potato is a leading human staple diet ... it. Its importance as a food is due to its nutritive ... and phosphorous content. The pattern of consumption has changed over the ... is increasingly common for the potato to get to homes, not ...
... to Providing High Quality Services to the CommunityLOS ... ("Avanti") is pleased to announce that it has ... Gardena ("MHG") and East Los Angeles Doctors Hospital ... been providing quality acute and sub-acute healthcare services ...
... BeaconEquity.com announces the availability of Trade Alerts on stocks ... trading notes for free by visiting: http://www.BeaconEquity.com/m Today,s ... ), Abbott Laboratories (NYSE: ABT ), Eli Lilly ... PFE ), Novartis AG (NYSE: NVS ...
... the Company,s line of health and beauty productsMOUNTAIN ... AdEx Media, Inc. (OTC Bulletin Board: ADXM), a ... company, today announced the addition of Acai Alive(TM), ... and beauty products. Acai Alive(TM) was formulated ...
Cached Medicine News:Health News:Research increases possibilities of personalizing treatment of infant osteosarcoma 2Health News:Research increases possibilities of personalizing treatment of infant osteosarcoma 3Health News:An atmosphere rich in CO2 and oxygen enhances the quality of refrigerated potato 2Health News:An atmosphere rich in CO2 and oxygen enhances the quality of refrigerated potato 3Health News:Avanti Health System Acquires Two Los Angeles Hospitals 2Health News:Avanti Health System Acquires Two Los Angeles Hospitals 3Health News:Avanti Health System Acquires Two Los Angeles Hospitals 4Health News:Beacon Equity Issues Technical Trade Alerts on Drug Manufacturers: JNJ, ABT, LLY, PFE, NVS, GSK 2Health News:AdEx Media Introduces Acai Alive(TM) 2Health News:AdEx Media Introduces Acai Alive(TM) 3
(Date:5/22/2015)... May 22, 2015  Effective staffing of key ... recognition and success. Research and ... to provide pharmaceutical and biotech marketing managers with ... budget) that are being channeled into marketing operations ... managers can utilize this report to benchmark their ...
(Date:5/22/2015)... May 22, 2015 The leading companies ... billion global cardiac rhythm management device market dominate ... that Medtronic, St. Jude Medical, Boston Scientific and ... this market segment. The healthcare market research publisher,s ... uses 2015 as a base year, providing forecasts ...
(Date:5/22/2015)... KING OF PRUSSIA, Pa. , May 22, 2015 /PRNewswire/ ... CSL Behring its 2015 Corporate Leadership Award as recognition ... and improving the care of the bleeding disorders community.  The ... Managing Director, CSL Limited, during the NHF Annual Spring Soiree ... 21. "The National Hemophilia Foundation is dedicated to ...
Breaking Medicine Technology:Effective Marketing Services Group Critical for Pharmaceutical Brand Recognition 2Kalorama: Top Companies Dominate Cardiac Defibrillator Market 2Kalorama: Top Companies Dominate Cardiac Defibrillator Market 3Kalorama: Top Companies Dominate Cardiac Defibrillator Market 4National Hemophilia Foundation Honors CSL Behring with Corporate Leadership Award 2National Hemophilia Foundation Honors CSL Behring with Corporate Leadership Award 3National Hemophilia Foundation Honors CSL Behring with Corporate Leadership Award 4
... Focus from Thermo Labsystems was designed specifically ... Advanced features such as the new fast ... on microvolumes help to define this as ... The new interchangeable handle plate offers a ...
... The new Finnpipette Focus from Thermo Labsystems ... uncompromising performance. Advanced features such as ... fine volume adjustment on microvolumes help to ... single channel pipettes. The new interchangeable handle ...
Research Series 2100 Adjustable-volume Pipette, 0.1-2.5 l, single-channel with adjustable-volume setting...
... The Finnpipette Digital offers improved ergonomics ... rounded handle, modified grippy finger rest ... operator comfort and efficiency. Finnpipette Digitals ... power-boosted gearing mechanism (pat. pend.) and ...
Medicine Products: