Navigation Links
Study identifies growth factor essential to the most common malignant pediatric brain tumor
Date:2/28/2013

A multi-institutional team led by Massachusetts General Hospital (MGH) researchers has identified a molecular pathway that appears to be essential for the growth and spread of medulloblastoma, the most common malignant brain tumor in children. In their report in the Feb. 28 issue of Cell, they show that blocking this pathway which involves interactions between tumor cells and the surrounding tissues leads to regression of all four molecular subtypes of medulloblastoma in several mouse models.

"Our finding that a pathway carrying signals from host cells to tumor cells via placental growth factor and its receptor neuropilin 1 is critical to the growth of medulloblastoma, regardless of molecular subtype, strongly supports evaluating antibodies against these proteins as a novel therapeutic approach to this pediatric cancer," says Rakesh K. Jain, PhD, director of the Steele Laboratory for Tumor Biology at MGH and corresponding author of the study.

A highly malignant tumor that originates in the cerebellum, medulloblastoma accounts for about 20 percent of all pediatric brain tumors and is ten times more common in children than in adults. While aggressive treatment with surgery, chemotherapy and radiation significantly improves patient survival, those treatments can have long-term developmental, behavioral, and neurological side effects, particularly in the youngest patients, making the need for less damaging therapies essential.

Impetus for the current investigation began with studies by Peter Carmeliet, MD, PhD, of the Vesalius Research Center in Belgium, a co-author of the current study. Carmeliet found that an antibody against placental growth factor (PlGF) could block angiogenesis in a number of adult tumors. Since PlGF, unlike other angiogenic proteins, is not required for normal postnatal development, Jain and his Steele Lab colleague Lei Xu, MD, PhD, proposed targeting PlGF as anti-angiogenic treatment for pediatric t
'/>"/>

Contact: Katie Marquedant
kmarquedant@partners.org
617-726-0337
Massachusetts General Hospital
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Study finds diabetes does not increase risk of total knee surgical complications
2. Too Much Sitting Could Court Diabetes, Study Finds
3. UCLA study could explain why some people get zits and others dont
4. Babies Born to Obese Women Show Thicker Arteries: Study
5. Siblings Death May Boost Your Own Risk of Dying From Heart Attack: Study
6. Costs of ER Visits Vary in U.S., Study Finds
7. Einstein receives $3 million to study impact of soccer heading on the brain
8. Retailers should re-size maternity wear for women throughout their pregnancies, MU study finds
9. More Younger Women Diagnosed With Advanced Breast Cancer: Study
10. Dog Study Raises Prospect of Biological Pacemaker for Humans
11. Surgery and radiation improve survival for metastatic gastric cancer patients, Moffitt study shows
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study identifies growth factor essential to the most common malignant pediatric brain tumor
(Date:4/25/2015)... 2015 The Hon. Ellen Tauscher, Independent ... the following statement following the deadly earthquake in Nepal: ... resulting in the deaths of more than 1,000 people. ... across Nepal, Bangladesh, India and other parts of South ... to the people of Nepal and the families of ...
(Date:4/25/2015)... (PRWEB) April 25, 2015 Carinsurancequotesinfo.com has ... find low cost auto insurance for flatbed ... heavy goods and sometimes other vehicles. They are mainly ... insurance. The newly released blog post explains that by ... for trucks, vans and other commercial vehicles. , It ...
(Date:4/25/2015)... 25, 2015 An expanded and newly ... of successfully welcoming visitors to the Turks and Caicos ... As part of a major construction project occurring in ... redesigned to speed up arrivals. A new exterior ... out of the airport and onto Grace Bay beach! ...
(Date:4/25/2015)... New York (PRWEB) April 25, 2015 The ... Dr. Jerry Blaivas has been chosen by the New York ... his contributions to medicine in the field of Urology. , ... best in his speciality, Genito-Urinary diseases. He was a ... in the field of urology. Not only did he ...
(Date:4/25/2015)... 2015 For thirteen years, the Twin Cities ... education event in the nation! This year, on May 5th, ... US to take DI Day on the road by supporting ... CLU, ChFC, RHU, DIA, CLTC, Chief Executive Officer at Secura ... on the change by stating, "The first Twin Cities DI ...
Breaking Medicine News(10 mins):Health News:Auto Insurance Quotes for Flatbed Trucks Available Online! 2Health News:The Tuscany on Grace Bay Celebrates Providenciales Airport Expansion With Summer Specials to Travelers! 2Health News:The 2015 Valentine Award Comes From The Heart and Goes To Famous New York Urologist 2Health News:The 2015 Valentine Award Comes From The Heart and Goes To Famous New York Urologist 3Health News:Secura Consultants Takes DI Day On The Road 2
... words today throughout the country are 'Dengue' and ... the bite of an infected// Aedes aegypti female ... states. Dengue is the most common mosquito-borne viral ... administrative machinery is battling with a situation that is threatening ...
... normally used to treat ulcers, was found to prevent ... women in developing countries, according// to a study conducted ... India's Jawaharlal Nehru Medical College, and the National Institutes ... Oct. 8 issue of Lancet, found misoprostol reduced the ...
... pregnant women suffering from malaria was found to be safe ... and at the London School of Hygiene & Tropical Medicine ... the malarial parasite without any serious side effects in the ... only with the drug amodiaquine or in combination with sulphadoxine-pyrimethamine ...
... of bowel cancer is greater among women than among men ... a Sydney study that was carried on 1200 bowel cancer ... likely to die from their disease compared to males. On ... aged 50 and under actually had a better survival rate ...
... of stroke in Perth, Western Australia by 43% over the ... George Institute for International Health at the Annual Scientific Meeting ... ,Stroke affects around 17 million people globally and is ... Nationally, over 53,000 strokes occur each year, of which one ...
... in the HIV/AIDS prevalence rate in Kenya from 6.1% in ... Control Council of Kenya (NACC) released the latest data, according ... 9.6 % whereas in rural areas it is 4.6%.,A variety ... preventing pregnant HIV-positive mothers from passing the virus to their ...
Cached Medicine News:Health News:Dengue and Chikungunya: The Dirge of a Nation 2Health News:Dengue and Chikungunya: The Dirge of a Nation 3Health News:Dengue and Chikungunya: The Dirge of a Nation 4Health News:Ulcer Drug Could Save Lives of Women in Developing Countries 2Health News:New method to treat malaria in pregnant women 2Health News:Increased Risk of Bowel cancer after Menopause 2Health News:Declining Incidence of stroke in Australia 2Health News:Decrease in AIDS prevalence rate in Kenya 2
(Date:4/24/2015)... -- Introduction of new "Elements" ... for radiosurgery/SBRT   The "Elements" strategy ... the workflow for difficult to treat indications in ... comes full circle with the introduction of automated ... enable on-the-fly generation of consistent treatment plans for ...
(Date:4/24/2015)... T-Bird Pharma Inc. (TSXV:TPI) ("T-Bird" or the "Company"), a ... products and a licensed producer ("LP") to cultivate marijuana ... Canada ) ("MMPR"), is pleased to announce that ... the transaction announced on March 11, 2015 with Medna ... a total of 20,156,790 common shares of T-Bird (45% ...
(Date:4/23/2015)... Lifesciences Corporation (NYSE: EW ), the global leader ... today reported net income for the quarter ended March 31, ... Net income for the same period a year earlier ... non-GAAP net income was $82.1 million, or $0.76 per ... ended March 31, 2015 increased 13.0 percent to $590.3 million ...
Breaking Medicine Technology:Brainlab Introduces New Generation of VMAT* for Brain and Spine at 3rd ESTRO in Barcelona 2T-Bird Pharma Inc. Announces Closing of Transaction with Medna Biosciences 2T-Bird Pharma Inc. Announces Closing of Transaction with Medna Biosciences 3Edwards Lifesciences Reports First Quarter Results 2Edwards Lifesciences Reports First Quarter Results 3Edwards Lifesciences Reports First Quarter Results 4Edwards Lifesciences Reports First Quarter Results 5Edwards Lifesciences Reports First Quarter Results 6Edwards Lifesciences Reports First Quarter Results 7Edwards Lifesciences Reports First Quarter Results 8Edwards Lifesciences Reports First Quarter Results 9Edwards Lifesciences Reports First Quarter Results 10Edwards Lifesciences Reports First Quarter Results 11Edwards Lifesciences Reports First Quarter Results 12Edwards Lifesciences Reports First Quarter Results 13Edwards Lifesciences Reports First Quarter Results 14Edwards Lifesciences Reports First Quarter Results 15Edwards Lifesciences Reports First Quarter Results 16
... spinal company continues to focus on unmet needs of the lumbar ... ... disc, MINNEAPOLIS, May 1 CoreSpine Technologies, LLC, an,emerging spinal ... implant procedures to include an application,for minimally invasive fusion., The ...
... predict life-long tendency to inflammation ... related cardiovascular event risk profile, WALTHAM, Mass., May ... announced publication of the results of clinical,studies that support ... The article, titled, "IL1B Gene Promoter Haplotype,Pairs Predict Clinical ...
Cached Medicine Technology:CoreSpine Technologies Expands Spinal Disc Site Preparation Efforts 2Video: The Journal, Human Genetics, Publishes Results Supporting Interleukin Genetics' Heart Health Test 2Video: The Journal, Human Genetics, Publishes Results Supporting Interleukin Genetics' Heart Health Test 3Video: The Journal, Human Genetics, Publishes Results Supporting Interleukin Genetics' Heart Health Test 4Video: The Journal, Human Genetics, Publishes Results Supporting Interleukin Genetics' Heart Health Test 5
... Unparalleled Comfort Pick one of our pipettors ... the trigger and ejector positionsright where they should ... are ergonomically designed to help avoid repetitive stress ... Productivity In The Palm Of Your Hand ...
... for Unparalleled Comfort Pick one of our ... Notice the trigger and ejector positionsright where they ... pipettors are ergonomically designed to help avoid repetitive ... Productivity In The Palm Of Your Hand ...
... Ergonomic Design for Unparalleled Comfort Pick ... Notice the balance. Notice the trigger and ejector ... Thats because our pipettors are ergonomically designed to ... hours of pipetting. Productivity In The Palm ...
... The total ergonomic solution and best value ... feather touch action and ultra lightweight design ... tip ejection with long, lever tip ejector ... , Accepts universal tips or for greater ...
Medicine Products: