Navigation Links
Study identifies growth factor essential to the most common malignant pediatric brain tumor
Date:2/28/2013

A multi-institutional team led by Massachusetts General Hospital (MGH) researchers has identified a molecular pathway that appears to be essential for the growth and spread of medulloblastoma, the most common malignant brain tumor in children. In their report in the Feb. 28 issue of Cell, they show that blocking this pathway which involves interactions between tumor cells and the surrounding tissues leads to regression of all four molecular subtypes of medulloblastoma in several mouse models.

"Our finding that a pathway carrying signals from host cells to tumor cells via placental growth factor and its receptor neuropilin 1 is critical to the growth of medulloblastoma, regardless of molecular subtype, strongly supports evaluating antibodies against these proteins as a novel therapeutic approach to this pediatric cancer," says Rakesh K. Jain, PhD, director of the Steele Laboratory for Tumor Biology at MGH and corresponding author of the study.

A highly malignant tumor that originates in the cerebellum, medulloblastoma accounts for about 20 percent of all pediatric brain tumors and is ten times more common in children than in adults. While aggressive treatment with surgery, chemotherapy and radiation significantly improves patient survival, those treatments can have long-term developmental, behavioral, and neurological side effects, particularly in the youngest patients, making the need for less damaging therapies essential.

Impetus for the current investigation began with studies by Peter Carmeliet, MD, PhD, of the Vesalius Research Center in Belgium, a co-author of the current study. Carmeliet found that an antibody against placental growth factor (PlGF) could block angiogenesis in a number of adult tumors. Since PlGF, unlike other angiogenic proteins, is not required for normal postnatal development, Jain and his Steele Lab colleague Lei Xu, MD, PhD, proposed targeting PlGF as anti-angiogenic treatment for pediatric t
'/>"/>

Contact: Katie Marquedant
kmarquedant@partners.org
617-726-0337
Massachusetts General Hospital
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Study finds diabetes does not increase risk of total knee surgical complications
2. Too Much Sitting Could Court Diabetes, Study Finds
3. UCLA study could explain why some people get zits and others dont
4. Babies Born to Obese Women Show Thicker Arteries: Study
5. Siblings Death May Boost Your Own Risk of Dying From Heart Attack: Study
6. Costs of ER Visits Vary in U.S., Study Finds
7. Einstein receives $3 million to study impact of soccer heading on the brain
8. Retailers should re-size maternity wear for women throughout their pregnancies, MU study finds
9. More Younger Women Diagnosed With Advanced Breast Cancer: Study
10. Dog Study Raises Prospect of Biological Pacemaker for Humans
11. Surgery and radiation improve survival for metastatic gastric cancer patients, Moffitt study shows
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study identifies growth factor essential to the most common malignant pediatric brain tumor
(Date:12/25/2014)... Recently, Dylan Queen, a famous online company supplying women’s ... discounted prom dresses, most of which are priced under ... company, the promotion is valid until Jan. 22, 2015; ... UK market. , The prom dresses in this new ... A-line strapless, empire strapless chiffon, one shoulder, floor-length, V-neck ...
(Date:12/25/2014)... California (PRWEB) December 25, 2014 Helen ... home in Woodland Hills, California after an 8 year ... away on Christmas Eve evening in her home in ... aggressive metastatic breast cancer. , As ... over forty years, she pioneered and championed many of ...
(Date:12/25/2014)... THURSDAY, Dec. 25, 2014 (HealthDay News) -- The risk ... the holidays, so you need to be extra cautious, ... Day, we see a significant increase in patients coming ... at the Suffolk County Volunteer Firefighters Burn Center of ... celebrations should be full of joy, but if not ...
(Date:12/25/2014)... AngelWeddingDress.com tries its best to translate ... Today, the business has introduced its new collection of ... promotion. , The new prom outfits are guaranteed to ... lover. They are specially designed for 2015. Anyone who ... should visit its website before Jan. 26, 2015, the ...
(Date:12/25/2014)... 2014 Residents at Abernethy ... showed their generous spirit by providing holiday gifts ... Parenting Network- Grandparents Raising Grandchildren program. , Following ... the largest Christmas tree on the campus of ... residents of the Abernethy Village Association (AVA). Each ...
Breaking Medicine News(10 mins):Health News:Dylan Queen: Cheap Prom Dresses for the UK Market 2Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 2Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 3Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 4Health News:Don't Let Burns Mar Your Holidays 2Health News:Angelweddingdress 2015 Prom Dresses Online Now 2Health News:Retirement Community Residents Make Impact During Holiday Season 2
... February is Heart ... … while having fun, too. , ... Los Angeles (Vocus) January 25, 2010 -- Every year, over 40,000 American women die ... to be one of them! , , , , ,February is Heart Health Month. Self-care ...
... ... hablan de disparidades e instan a los grupos de socorro a que tengan en ... ... del pasado indica que probablemente las mujeres y los niños en Haití no estén ...
... Center at the University of California, San Diego and ... between county hospitals and private providers. Patients treated in ... patients treated in private facilities tend to receive radiation ... the journal Cancer on January 25. ...
... Children who are mixed-handed, or ambidextrous, are more likely ... childhood than right- or left-handed children, according to a ... . The researchers behind the study, from ... their findings may help teachers and health professionals to ...
... ... the Christian perspective, promote faith-formation. , ... (PRWEB) January 24, 2010 -- Witness to Hope Ministries, a nonprofit ... behavioral health practice in Beaver, PA in order to serve at-risk and special needs ...
... 24, 2010 When University of Utah scientists discovered a ... conducting plastic or polymer, no one could explain how it ... later, the Utah researchers have found these "random lasers" occur ... say such lasers may prove useful for diagnosing cancer. ...
Cached Medicine News:Health News:Save The Ta-Ta's ... And Your Ticker 2Health News:Save The Ta-Ta's ... And Your Ticker 3Health News:Estn las Mujeres y los Nios de Hait Recibiendo Menos Ayuda Tras el Terremoto? 2Health News:Estn las Mujeres y los Nios de Hait Recibiendo Menos Ayuda Tras el Terremoto? 3Health News:Estn las Mujeres y los Nios de Hait Recibiendo Menos Ayuda Tras el Terremoto? 4Health News:Study confirms prostate cancer is treated differently at county vs. private hospitals 2Health News:Mixed-handed children more likely to have mental health, language and scholastic problems 2Health News:Mixed-handed children more likely to have mental health, language and scholastic problems 3Health News:Christian Nonprofit and Behavioral Health Practice Team Up to Help Children 2Health News:How 'random' lasers work 2Health News:How 'random' lasers work 3Health News:How 'random' lasers work 4Health News:How 'random' lasers work 5
(Date:12/24/2014)... LEXINGTON, Mass. , Dec. 23, 2014 /PRNewswire/ ... GEVA ), a biopharmaceutical company developing therapeutic products ... European Medicines Agency (EMA) of the Marketing Authorization ... The EMA recently granted the company,s request for ... the EMA,s regulatory review time.   ...
(Date:12/24/2014)... 2014  Lockton Dunning Benefits, the ... the addition of Vice President Kim Foerster ... Pharmacy Consulting team, Excelsior Solutions. ... to the position.  Most recently, she worked as ... Specialty Pharmacy, where she has held various managerial ...
(Date:12/24/2014)... 23, 2014 Tianyin Pharmaceutical Co., Inc. ... in patented biopharmaceutical, modernized traditional Chinese medicine (mTCM), ... announced that the Company achieved the Public Notice ... (GMP) certificate of TPI,s Qionglai Facility (QLF) from ... public notice period is a significant procedure of ...
Breaking Medicine Technology:Synageva BioPharma Announces Sebelipase Alfa Marketing Authorization Application Validated By The EMA 2Synageva BioPharma Announces Sebelipase Alfa Marketing Authorization Application Validated By The EMA 3Kim Foerster Joins Lockton Companies 2TPI QLF Achieved Public Notice Status of GMP Certification 2TPI QLF Achieved Public Notice Status of GMP Certification 3
... flexible continuous monitoring, the M3 and M4 ... and neonatal patient care. M Series monitors ... includes a basic set of non-invasive parameters ... Optional Multi-Measurement Server extensions offer Mainstream or ...
... On-line Electronic Help (OLEH), an ... to critical anesthesia-related information. OLEH brings ... need it most right on ... care of the patient and ...
Compact networked patient monitors for flexible care....
... for flexible care settings., ,IntelliVue ... portability and measurement flexibility to match ... intermediate care environmentsat the patients side., ... in patient monitoring, IntelliVue has highly ...
Medicine Products: