Navigation Links
Study identifies genetic basis of human metabolic individuality
Date:10/26/2011

NEW YORK -- In what is so far the largest investigation of its kind, researchers uncovered a wide range of new insights about common diseases and how they are affected by differences between two persons' genes. The results from this study could lead to highly targeted, individualized therapies.

Led by researchers from Weill Cornell Medical College in Qatar and published in a recent edition of the journal Nature, the study provides details on the genetics behind many diseases, including cardiovascular and kidney disorders, diabetes, cancer, gout, thrombosis and Crohn's disease, and elucidates the role that individual differences in metabolism play in these disorders.

Disturbances in metabolism are at the root of a variety of human afflictions and complex diseases. Although many of the genes that contribute to these conditions have been identified since the completion of the Human Genome Project in 2003, it is still not known how metabolic disorders related to these genetic aberrations disrupt cellular processes.

One hundred years ago, Archibald Garrod, one of the fathers of modern biochemistry, realized that inborn errors in human metabolism are "merely extreme examples of variations of chemical behavior which are probably everywhere present in minor degrees" and that this "chemical individuality [confers] predisposition to and immunities from the various mishaps which are spoken of as diseases." Ever since, identification of the genetic basis of human chemical individuality has been elusive.

Now researchers addressed this challenge by using a new technology, called metabolomics. They measured the levels of more than 250 biochemical compounds in over 60 metabolic pathways, including lipids, sugars, vitamins, amino acids and others in blood from over 2,800 individuals. They then combined this dataset with information on more than 600,000 genetic variants (SNPs) that were detected in the genes of each of the study parti
'/>"/>

Contact: John Rodgers
jdr2001@med.cornell.edu
212-821-0560
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Study indicates nanoparticles could help pain-relieving osteoarthritis drugs last longer
2. Study shows why underrepresented men should be included in binge eating research
3. Some Asthma Drugs Raise Risk of Complications, Especially in Kids: Study
4. Sleepy Teens More Prone to Weight Gain: Study
5. Scott & White Healthcare and American Cancer Society enter into partnership for prevention study
6. IADR/AADR publish study on dental caries vaccine
7. Penn study explains paradox of insulin resistance genetics
8. Wayne State University study of heroin users to examine links between stress, drug use
9. Study Casts Doubt on Hot Dogs Link to Colon Cancer
10. Study: Obesity limits effectiveness of flu vaccines
11. Soft Drinks Linked to Violent Tendencies in Teens: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2015)... ... ... Ross A. Clevens, MD, FACS has been reappointed by the University ... This is Dr. Clevens’ second appointment by the prestigious school. Over the past ... and a valuable mentoring program for medical students. , The University ...
(Date:7/30/2015)... Beach, California (PRWEB) , ... July 30, 2015 ... ... and services, announced today that the latest issue of Inclusive™ magazine, its multimedia ... digital platforms. The digital edition of the new issue, Volume 6, Issue 2, ...
(Date:7/30/2015)... ... July 30, 2015 , ... ... Partners All-Star at the annual All-Stars Summit. Google Partners is the platform for ... may receive the full support and tools necessary to run successful search marketing ...
(Date:7/30/2015)... , ... July 30, 2015 , ... Quintessa Medical Spa ... is a nonsurgical treatment designed specifically for the elimination of excess tissue ... the first locations in the state of Wisconsin to offer this innovative treatment. , ...
(Date:7/30/2015)... , ... July 30, 2015 , ... ... Administration (DEA) Acting Administrator Chuck Rosenberg’s announcement of the reinstitution of National Prescription ... Saturday, September 26, 2015 from 10:00 AM to 2:00 PM local time. On ...
Breaking Medicine News(10 mins):Health News:Leading Melbourne Facial Plastic Surgeon Reappointed by UCF 2Health News:Leading Melbourne Facial Plastic Surgeon Reappointed by UCF 3Health News:Glidewell Laboratories Puts Out Latest Issue of Dental Implant Magazine Inclusive™ 2Health News:Glidewell Laboratories Puts Out Latest Issue of Dental Implant Magazine Inclusive™ 3Health News:Glidewell Laboratories Puts Out Latest Issue of Dental Implant Magazine Inclusive™ 4Health News:Boston Web Marketing Attends Google Partners All-Stars Summit 2Health News:Quintessa MedSpa Offers Nonsurgical Double-chin Elimination 2Health News:AAPCC Supports National Prescription Drug Take-Back Day 2Health News:AAPCC Supports National Prescription Drug Take-Back Day 3
... NY (March 3, 2009) A study published in the ... (AJN) found that almost 40% of nurses who were on ... misconduct between 2001 and 2005. Nurses on probation who ... recidivate, suggesting that licensing boards should carefully screen and monitor ...
... this country. Many employers don,t want to hire them, and ... their own communities and families, the mentally ill are often ... efforts to combat the stigma of mental illness, but with ... are so powerful: Mental patients are either violently dangerous or ...
... March 3 /PRNewswire-USNewswire/ - - The following ... Action Network, American Heart Association, American Lung Association ... strongly support the bipartisan legislation introduced today to ... with effective authority to regulate tobacco products. ...
... undamaged areas to compensate, study finds , , TUESDAY, March ... to start losing his or her sight, the affected ... parts of the eye, Massachusetts Institute of Technology researchers ... the brain changes when its inputs change. Neurons seem ...
... 3 Tyco International Ltd. (NYSE: TYC ; ... a Special General Meeting of shareholders on March 12, 2009 ... The Annual General Meeting will begin at 9:00 a.m. ... Meeting at 9:30 a.m. Atlantic Time. During the meetings, ...
... Center is participating in a National Institutes of Health ... to reduce the risk of stroke patients suffering another ... stroke victims for high blood pressure and cholesterol, along ... in a patient,s brain, is better than intensive medical ...
Cached Medicine News:Health News:New research in AJN shows link between nurse's criminal history and professional misconduct 2Health News:New research in AJN shows link between nurse's criminal history and professional misconduct 3Health News:His and hers: Study examines the role of gender in the stigma of mental illness 2Health News:Congress Can Deliver Historic Victory for Children and America's Health By Granting FDA Authority Over Tobacco Products 2Health News:Congress Can Deliver Historic Victory for Children and America's Health By Granting FDA Authority Over Tobacco Products 3Health News:Brain Adapts to Age-Related Eye Disease 2Health News:Tyco to Host 2009 Annual General Meeting and Special General Meeting of Shareholders 2Health News:Preventing a second stroke is focus of study at Rush University Medical Center 2
(Date:7/30/2015)... , July 30, 2015  NanoSmart Pharmaceuticals, Inc., ... platforms, has received Orphan Drug Designation from the ... drug product that uses NanoSmart,s proprietary drug delivery ... dactinomycin for the treatment of Ewing,s sarcoma, a ... granted NanoSmart,s Orphan Drug Designation on the basis ...
(Date:7/30/2015)... 30, 2015  Arena Pharmaceuticals, Inc. (NASDAQ: ARNA ... and webcast at 5:00 p.m. Eastern Time (2:00 p.m. ... second quarter 2015 financial results and provide a corporate ... NASDAQ Global Select Market closes that day. ... for domestic callers and 914.495.8552 for international callers. Please ...
(Date:7/30/2015)... , July 30, 2015 EnteroMedics Inc. (NASDAQ: ... neuroblocking technology to treat obesity, metabolic diseases and other ... conference call on Thursday, August 6, 2015, at 11:00 ... second quarter ended June 30, 2015, and to provide ... Neurometabolic Therapy, delivered via the Maestro® System. ...
Breaking Medicine Technology:NanoSmart Receives Second FDA Orphan Drug Designation for Treatment of Pediatric Cancer 2Arena Pharmaceuticals to Host Second Quarter 2015 Financial Results and Corporate Update Conference Call and Webcast on Wednesday, August 5 2Arena Pharmaceuticals to Host Second Quarter 2015 Financial Results and Corporate Update Conference Call and Webcast on Wednesday, August 5 3Arena Pharmaceuticals to Host Second Quarter 2015 Financial Results and Corporate Update Conference Call and Webcast on Wednesday, August 5 4EnteroMedics to Host Second Quarter 2015 Financial Results and Company Update Conference Call 2EnteroMedics to Host Second Quarter 2015 Financial Results and Company Update Conference Call 3
... May 18 AccuVein LLC today announced it had signed ... sell the AV300 vein finder in India . With ... , , ... veins for blood draw , IV infusion and blood ...
... SAN FRANCISCO , May 18 Teva ... treated with a standard or low dose of ENJUVIA® (synthetic ... often they were awakened at night by hot flashes compared ... at the 58th Annual Clinical Meeting of the American College ...
Cached Medicine Technology:AccuVein Signs Exclusive Distribution Agreement in India to Sell Vein Illumination Device 2AccuVein Signs Exclusive Distribution Agreement in India to Sell Vein Illumination Device 3New Study Shows ENJUVIA® Significantly Reduced 'Sleep Time' Awakenings Caused by Hot Flashes in Postmenopausal Women 2New Study Shows ENJUVIA® Significantly Reduced 'Sleep Time' Awakenings Caused by Hot Flashes in Postmenopausal Women 3New Study Shows ENJUVIA® Significantly Reduced 'Sleep Time' Awakenings Caused by Hot Flashes in Postmenopausal Women 4New Study Shows ENJUVIA® Significantly Reduced 'Sleep Time' Awakenings Caused by Hot Flashes in Postmenopausal Women 5New Study Shows ENJUVIA® Significantly Reduced 'Sleep Time' Awakenings Caused by Hot Flashes in Postmenopausal Women 6New Study Shows ENJUVIA® Significantly Reduced 'Sleep Time' Awakenings Caused by Hot Flashes in Postmenopausal Women 7
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: