Navigation Links
Study identifies genetic basis of human metabolic individuality
Date:10/26/2011

NEW YORK -- In what is so far the largest investigation of its kind, researchers uncovered a wide range of new insights about common diseases and how they are affected by differences between two persons' genes. The results from this study could lead to highly targeted, individualized therapies.

Led by researchers from Weill Cornell Medical College in Qatar and published in a recent edition of the journal Nature, the study provides details on the genetics behind many diseases, including cardiovascular and kidney disorders, diabetes, cancer, gout, thrombosis and Crohn's disease, and elucidates the role that individual differences in metabolism play in these disorders.

Disturbances in metabolism are at the root of a variety of human afflictions and complex diseases. Although many of the genes that contribute to these conditions have been identified since the completion of the Human Genome Project in 2003, it is still not known how metabolic disorders related to these genetic aberrations disrupt cellular processes.

One hundred years ago, Archibald Garrod, one of the fathers of modern biochemistry, realized that inborn errors in human metabolism are "merely extreme examples of variations of chemical behavior which are probably everywhere present in minor degrees" and that this "chemical individuality [confers] predisposition to and immunities from the various mishaps which are spoken of as diseases." Ever since, identification of the genetic basis of human chemical individuality has been elusive.

Now researchers addressed this challenge by using a new technology, called metabolomics. They measured the levels of more than 250 biochemical compounds in over 60 metabolic pathways, including lipids, sugars, vitamins, amino acids and others in blood from over 2,800 individuals. They then combined this dataset with information on more than 600,000 genetic variants (SNPs) that were detected in the genes of each of the study parti
'/>"/>

Contact: John Rodgers
jdr2001@med.cornell.edu
212-821-0560
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Study indicates nanoparticles could help pain-relieving osteoarthritis drugs last longer
2. Study shows why underrepresented men should be included in binge eating research
3. Some Asthma Drugs Raise Risk of Complications, Especially in Kids: Study
4. Sleepy Teens More Prone to Weight Gain: Study
5. Scott & White Healthcare and American Cancer Society enter into partnership for prevention study
6. IADR/AADR publish study on dental caries vaccine
7. Penn study explains paradox of insulin resistance genetics
8. Wayne State University study of heroin users to examine links between stress, drug use
9. Study Casts Doubt on Hot Dogs Link to Colon Cancer
10. Study: Obesity limits effectiveness of flu vaccines
11. Soft Drinks Linked to Violent Tendencies in Teens: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... -- People with higher levels of brown fat have ... study suggests. Unlike white fat, which lowers insulin ... sensitivity, blood sugar control and fat-burning metabolism. "This ... Sidossis, a professor of internal medicine in the division ... Branch at Galveston, said in a university news ...
(Date:7/28/2014)... Va., July 28, 2014A two-step decision tree analysis, ... evaluate and distill the many available quality standards, ... update national and international quality standards for radiation ... July-August 2014 issue of Practical Radiation Oncology ... the American Society for Radiation Oncology (ASTRO). , ...
(Date:7/28/2014)... A young couple from a small North Carolina ... media today about parents accidentally leaving children in hot ... in a hot car. July 31 is National Heatstroke ... Services at NHTSA. , Shaun and Kimberly Johnston created ... all too easy to get distracted, the app simply ...
(Date:7/28/2014)... According to a new market research report, "Compound ... Deposition Technology (CVD, MBE, HVPE, Ammonothermal, MOVPE, ... published by MarketsandMarkets, the market is expected to ... to 2020 and reach $104.55 billion in 2020. ... figures spread through 342 pages and in-depth TOC ...
(Date:7/28/2014)... Ridgeland, MS (PRWEB) July 28, 2014 ... recently announced the graduates of its Advanced Training ... students, who fill roles in their health care ... the theory and methodology of continuous quality improvement ... a sister-program to Dr. Brent James’ internationally recognized ...
Breaking Medicine News(10 mins):Health News:Healthy 'Brown Fat' May Cut Odds for Obesity, Diabetes 2Health News:Two-step decision tree analysis helps inform updates of RT best practices, quality standards 2Health News:Two-step decision tree analysis helps inform updates of RT best practices, quality standards 3Health News:'Precious Cargo' App Released to Help Save Babies from the Dangers of Being Accidentally Left Behind in Hot Cars 2Health News:Compound Semiconductor Market by Type (III-V, II-VI, IV-IV, sapphire), Deposition Technology, Product Worth $104.55 Billion in 2020 - New Report by MarketsandMarkets 2Health News:Compound Semiconductor Market by Type (III-V, II-VI, IV-IV, sapphire), Deposition Technology, Product Worth $104.55 Billion in 2020 - New Report by MarketsandMarkets 3Health News:Compound Semiconductor Market by Type (III-V, II-VI, IV-IV, sapphire), Deposition Technology, Product Worth $104.55 Billion in 2020 - New Report by MarketsandMarkets 4Health News:HORNE LLP’s Healthcare Delivery Institute Graduates Class from the Advanced Training Program 2
... track environmental, genetic factors at six sites nationwide ... five-year study looking at the genetic and environmental factors ... delays, has started enrolling 2,700 children and their families ... Study to Explore Early Development -- which researchers called ...
... According to the,recently released follow-up study ... (MTA) in the August issue of the,Journal ... Adolescent Psychiatry,(JAACAP), children and young people with ... in combination with behavioral management and,educational adaptations ...
... in Chicago & Across the Nation Will,Discuss How Their ... Nov. 16 From November 17 through,the 25, AARP ... communities of,faith to ask them to reflect on the ... religious leaders will be,calling on their communities to create ...
... Nov. 16 The Association of,American Physicians and ... Georges county Maryland this week, and promised to ... to immunize their children., "This power play ... director of policy for the Association of American,Physicians ...
... Key biomarkers could point to women at higher risk, study ... believe they,re on the way to solving a major question ... in their breast duct that will progress to invasive disease? ... trying to get traction on this big clinical problem for ...
... a worldwide leader,in the development of highly effective, ... Lane has signed on to be,an ambassador for ... and inspiring actress who personifies the,Neutrogena(R) brand with ... new,role, she will be featured in national TV ...
Cached Medicine News:Health News:Major U.S. Autism Study Gets Under Way 2Health News:Divided We Fail 'Faith Week' to Raise Health and Financial Security Issues in Communities of Faith 2Health News:DOCTORS OPPOSE MARYLAND VACCINE ROUNDUP: Expect Dangerous Reactions When Children Are Treated Like Cattle 2Health News:DOCTORS OPPOSE MARYLAND VACCINE ROUNDUP: Expect Dangerous Reactions When Children Are Treated Like Cattle 3Health News:Cell Insights May Predict Breast Cancer's Spread 2Health News:Cell Insights May Predict Breast Cancer's Spread 3Health News:Update: Oscar-Nominated Actress Signs on as Neutrogena(R) Brand Ambassador 2
(Date:7/28/2014)... , July 28, 2014  Syneron Medical Ltd. ... device company, announced today that its new PicoWay® device ... all types and colors and pigmented lesions on any ... wavelength device, with 532nm and 1064nm wavelengths, which utilizes ... skin using pulses which are trillionths of a second, ...
(Date:7/28/2014)... 28, 2014  ResMed (NYSE: RMD ), ... treatment of sleep-disordered breathing and other chronic respiratory conditions, ... against Taiwanese medical device manufacturer APEX Medical ... APEX WiZARD 210 and 220 masks.  The judgment was ... Munich , is appealable, and applies throughout Germany.  ...
(Date:7/28/2014)... NEW PROVIDENCE, N.J. , July 28, ... invited to meet with Linde,s Healthcare division experts ... be held at McCormick Place in Chicago, ... "Hospitals demand nothing less than complete confidence in a ... Linde,s Healthcare Segment manager. "Linde understands the importance of ...
Breaking Medicine Technology:Syneron Announces CE Mark for PicoWay Dual Wavelength Picosecond Laser for Tattoo Removal and Treatment of Pigmented Lesions 2Syneron Announces CE Mark for PicoWay Dual Wavelength Picosecond Laser for Tattoo Removal and Treatment of Pigmented Lesions 3Syneron Announces CE Mark for PicoWay Dual Wavelength Picosecond Laser for Tattoo Removal and Treatment of Pigmented Lesions 4ResMed Receives Permanent Injunction against APEX in Germany, Continues Enforcement of Patents in Europe 2Linde's Healthcare division to display new Hospital Services platform at the national ASHE Conference in Chicago 2
... Inc. (Pink Sheets: SNDY ) is pleased to ... product line consisting of urology surgical and diagnostic instruments. The ... modifications to current product offerings, and five completely redesigned instruments; ... focus is to strengthen its domestic market share in the ...
... 2011 Colorcon, Inc., today announced the expansion ... to include PVA-based, high-productivity systems designed specifically for ... European Commission Directive (2010/69/EU), already ... existing additives in certain food supplement products.  The ...
Cached Medicine Technology:Solos Endoscopy, Inc. To Introduce New Urology Instrument Line 2
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: