Navigation Links
Study identifies genes associated with genomic expansions that cause disease
Date:9/10/2012

ple do not," said Kirill Lobachev, an associate professor in Georgia Tech's School of Biology. "We are trying to develop a simplistic way to determine what individuals may be predisposed to the disease and to find the genotypes where these expansions occur with great frequency."

At the core of the study was detailed screening of the yeast's entire genome, some 6,000 genes in all. Conducted by graduate research assistant Yu Zhang, the exhaustive assay identified 33 genes associated with the repeats fragility and expansions.

The connection between genomic expansion and genes that initiate transcription came as a surprise.

"We found that these repeats can recruit transcription initiation factors and induce transcription," said Lobachev. "The repeats seem to work as non-traditional promoters for an abnormal type of transcription. It turns out that this ability to drive transcription is a significant factor in their instability. That makes this a more complicated story for sure, however, it also opens new avenues to examine the repeats."

The ability of the repeats to affect the activity of genes may indicate a broader effect on the genome, and if the effect is also seen in humans, could account for some of the subtle differences between individuals.

"By some estimates, there may be a thousand locations in our chromosomes where these repeats can expand," said Lobachev. "Probably each person differs in the number of repeats in specific locations. This is important because of their ability to change gene expression."

Among the next steps in the research is to determine how the expansions occur in cells that aren't dividing, such as neurons. The genetic mechanisms involved in cell replication offer clear opportunities for repeat expansions, but the mechanism for repeat amplification in non-dividing cells remains a mystery. The researchers believe the finding that GAA/TTC repeats can promote transcription provides clues f
'/>"/>

Contact: John Toon
jtoon@gatech.edu
404-894-6986
Georgia Institute of Technology Research News
Source:Eurekalert  

0

GOOD

Page: 1 2 3

Related medicine news :

1. Multiple Methods Can Safely Help Babies Get to Sleep, Study Shows
2. Large lung cancer study shows potential for more targeted therapies
3. Chemo Brain After Breast Cancer Backed by Study
4. X-Rays May Up Breast Cancer Risk for Women With Certain Genes: Study
5. Cedars-Sinai Heart Institute awarded $1.3 million to study cardiac stem cells
6. Moffitt Cancer Center researchers study childhood melanoma characteristics
7. Does Studying for Law School Test Boost Your Brain?
8. Newer Rheumatoid Arthritis Drugs Dont Raise Cancer Risk: Study
9. Smokers Are Still High Schools Cool Kids, Study Finds
10. CDC traumatic brain injury study to test treatments, examine outcomes
11. Kids Develop Sense of Humor by Age 1, Study Finds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study identifies genes associated with genomic expansions that cause disease
(Date:5/23/2013)... THURSDAY, May 23 (HealthDay News) -- A modified ... help fight brain tumors, preliminary research suggests. ... investigational therapy, known as PVSRIPO, uses an engineered ... normal cells, but attacks cancer cells. The therapy ... most common and aggressive brain tumor, they said. ...
(Date:5/23/2013)... when a woman harried by hot flashes says she,s ... published online in Menopause , the journal of ... objective tests that what these women say about their ... showed that hot flashes were related to memory problems, ... there was a relationship between hot flashes and what ...
(Date:5/23/2013)... Williamsport, PA (PRWEB) May 23, 2013 ... Sitter® Teaching Site, offering a comprehensive babysitting training course ... nationally-recognized program was developed by Indianapolis pediatrician Dr. Patricia ... in the care of an adult sitter who didn’t ... a well-rounded youth development program with a medical basis ...
(Date:5/23/2013)... drug about to be tested in a clinical trial ... treatment for Alzheimer,s disease has failed to work with ... patients, according to results of a study by University ... of neuroscience affiliated with the Evelyn F. and William ... emphasized the importance of verifying promising research results before ...
(Date:5/23/2013)... 2013 The Rottenstein Law Group LLP, ... created the Tylenol Lawsuit Information Center at http://www.rotlaw.com/tylenol ... and those who are considering filing lawsuits. , ... cause severe liver damage, according to a 2009 report ... the “safety communication,” the FDA warned consumers against using ...
Breaking Medicine News(10 mins):Health News:Modified Polio Virus May Help Fight Brain Tumors, Study Suggests 2Health News:Susquehanna Health Offers Safe Sitter Course for Tweens and Teens 2Health News:Susquehanna Health Offers Safe Sitter Course for Tweens and Teens 3Health News:Anti-cancer drug viewed as possible Alzheimer's treatment doesn't work in UF study 2Health News:Anti-cancer drug viewed as possible Alzheimer's treatment doesn't work in UF study 3Health News:Rottenstein Law Group LLP Now Accepting Tylenol Cases, Announces New Tylenol Lawsuit Information Center 2
... School of Medicine have identified proteins in the rod and ... of the genetic causes of a host of inherited ... of what goes wrong at the most basic level in ... ,Specifically, they have identified and measured the types and amounts ...
... established a Scientific Advisory Board for its transplantation ... of its United States (U.S.) clinical development ... and Larry Chodoff LifeCycle Pharma A/S OMX:LCP) today ... Board (SAB) of experts in the field of ...
... Autistic children are invariably heavier than others. Researchers ... for Disease Control and Prevention and the Cincinnati ... be contributing to such a phenomenon. ,Other studies ... rapid head growth in early life. ,However, ...
... women graduating as doctors from Medical school than men. In a ... that 58% of doctors graduating from UK medical schools in ... pursuing a career as a doctor outnumber men by almost three ... five female doctors anticipate working part-time for most of their career. ...
... There were a lot of red faces among Texan lawmakers ... twice honored as the "doctor of the day," was ... with a 17-year-old. ,The "doctor of the day" is ... public with medical needs. ,Dr. Nilon Tallant, 75, ...
... Rutgers University study has claimed that being employed on ... cause both depression and anxiety. ,According toChester ... School of Business-Camden, the lunar settlements of tomorrow - ... - carry long-term implications for the mental health of ...
Cached Medicine News:Health News:Genetic Cause of Inherited Eye Diseases Identified 2Health News:LifeCycle Pharma Forms Scientific Advisory Board in Solid Organ Transplantation 2Health News:Autism Could Be Related to Higher Level of Growth Hormones 2Health News:More Women Medical Graduates Than Men 2Health News:Sex Offender Honored Twice by Texan Lawmakers 2
(Date:5/23/2013)... -- BioElectronics Corporation (OTC Pink: BIEL), the maker of very ... panel meeting for non-thermal shortwave diathermy: The ... Meeting was held on May 21, 2013 in ... the meeting was very narrow, in that the FDA ... application of non-thermal shortwave diathermy for the treatment of ...
(Date:5/23/2013)... May 23, 2013 Halozyme Therapeutics, Inc. ... appointment of David A. Ramsay ... most recently Vice President, Corporate Development at Halozyme. ... "With his established financial management experience and ... working in our commercial group for the last ...
(Date:5/23/2013)... CARLSBAD, Calif. , May 23, 2013 Isis ... antisense therapeutics, today announced that management will present a company ... Health Care Conference on Thursday, May 30, 2013 at 8:40 ... A live audio webcast of the presentation will be ... Web site, www.isispharm.com .  A replay will be available ...
Breaking Medicine Technology:BioElectronics and Pulsed Shortwave Therapy Make Progress 2Halozyme Therapeutics Names David A. Ramsay Chief Financial Officer 2Isis Pharmaceuticals to Present at the Deutsche Bank 38th Annual dbAccess Health Care Conference 2
... Resources, one of the world,s leading research and ... that the increased generic erosion of key drugs ... (Abbott/Sanofi-Aventis,s Depakote/Abbott,s Depakote ER, generics), combined with projected ... will cause a precipitous $2.3 billion decline in ...
... Aug. 25 Actelion Pharmaceuticals US, Inc., today ... (FDA) has approved the brand name VELETRI® for the ... available since April 2010 as Epoprostenol for Injection for ... (PAH) and PAH associated with the scleroderma spectrum of ...
Cached Medicine Technology:Through 2019, Increased Generic Erosion of Key Agents Such as Lamictal and Depakote/Depakote ER Will Cause a Precipitous $2.3 Billion Decline in the Bipolar Disorder Drug Market 2Actelion Pharmaceuticals Announces FDA Approval of Brand Name for Commercially Available VELETRI® (epoprostenol for injection) for Pulmonary Arterial Hypertension 2Actelion Pharmaceuticals Announces FDA Approval of Brand Name for Commercially Available VELETRI® (epoprostenol for injection) for Pulmonary Arterial Hypertension 3Actelion Pharmaceuticals Announces FDA Approval of Brand Name for Commercially Available VELETRI® (epoprostenol for injection) for Pulmonary Arterial Hypertension 4
Extremely wide blade opening. Excellent bio and MRI compatibility. Lot number on each clip. Long reliable history. Large type 1/1 (mm), opening width 7.0 mm and length 8.7 mm....
Extremely wide blade opening. Excellent bio and MRI compatibility. Lot number on each clip. Long reliable history. Large type 1/1 (mm), opening width 10.0 mm and length 10 mm....
Extremely wide blade opening. Excellent bio and MRI compatibility. Lot number on each clip. Long reliable history. Large type 1/1 (mm), opening width 8.0 mm and length 5 mm....
Extremely wide blade opening. Excellent bio and MRI compatibility. Lot number on each clip. Long reliable history. Large type 1/1 (mm), opening width 13.0 mm and length 15 mm....
Medicine Products: