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Study identifies factors linked with better medication response for treatment of juvenile arthritis
Date:11/6/2011

o received biologic agents. All biologically naive (had not previously received a biological agent) patients who started etanercept before October 2009 were included, with follow-up data to January 2011. Among the 262 patients, 185 (71 percent) were female, 46 (18 percent) had systemic-onset and the median (midpoint) age at initiation of etanercept treatment was 12.4 years.

For this study, response to treatment was evaluated 15 months after initiation of etanercept. Excellent response was defined as inactive disease or discontinuation earlier due to disease remission; intermediate response: more than 50 percent improvement from baseline, but no inactive disease; and poor response: less than 50 percent improvement from baseline or discontinuation earlier due to ineffectiveness or intolerance.

Of the 262 patients, 85 (32 percent) were considered excellent responders after 15 months of treatment; a total of 85 patients (32 percent) were considered poor responders; and the remaining 92 patients were considered intermediate responders. Compared with achieving an intermediate or poor response, achievement of an excellent response was associated with lower scores on measures of disability at study entry; low number of DMARDs (including methotrexate) used before introduction of etanercept; and younger age at onset. Compared with achieving an intermediate or excellent response, achievement of a poor response was associated with systemic JIA and female sex.

Within the first 15 months of treatment, 119 patients experienced 1 or more adverse events (infectious, noninfectious, or serious; including 37 patients with an excellent response, 36 with an intermediate response, and 46 with a poor response) and 53 patients reported at least 1 infectious adverse event or an infectious serious adverse event. Sixty-one patients discontinued etanercept treatment within the first 15 months of treatment, including 4 with an excellent response, 0 with an intermediat
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Contact: Marieke H. Otten, M.D., M.Sc.
m.otten@erasmusmc.nl
JAMA and Archives Journals
Source:Eurekalert

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