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Study identifies enzymes that help fix cancer-causing DNA defects
Date:4/23/2014

se enzymes in yeast and humans makes it likely that this method could be used to identify targets of Cdc14 in humans as well.

"Despite belonging to extremely different species, the 'lock' in yeast and human Cdc14 enzymes is exactly the same," he said. "That gives us confidence that we can use this strategy to identify substrates of human CDC14 and how they work to control DNA repair processes and prevent cancer."

Hall said understanding Cdc14's role in DNA repair and how the enzyme binds to its substrates could be used to develop more effective chemotherapeutic weapons against cancer. Many chemotherapeutic drugs work by producing such extensive DNA damage in cancer cells that they kill themselves. Designing a chemical that mimics the features of a Cdc14 substrate would help block Cdc14 from repairing damaged DNA in cancer cells, speeding their death.

"Developing Cdc14 inhibitory compounds could make certain cancer treatments more specific and potent," Hall said. "You could think of Cdc14 inhibitors as kryptonite to cancer cells, potentially weakening their ability to heal themselves and making them more vulnerable to chemotherapy treatment." Hall also is exploring the possibility of using Cdc14 inhibitors to combat deadly fungal diseases in crops.
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Contact: Natalie van Hoose
nvanhoos@purdue.edu
765-496-2050
Purdue University
Source:Eurekalert  

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