Navigation Links
Study identifies a likely key driver of colorectal cancer development and progression
Date:4/14/2014

COLUMBUS, Ohio A new study identifies a molecule that is a probable driving force in colorectal cancer and suggests that the molecule could be an important target for colorectal cancer treatment and a valuable biomarker of tumor progression.

The study of microRNA-135b (miR-135b) in two animal models and human tumors was published in the journal Cancer Cell and was led by researchers at The Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC James) and at the University of Glasgow in the United Kingdom.

The researchers demonstrate that miR-135b is present at abnormally high levels in both mouse and human colorectal (CRC) tumors. The overexpression can be induced by the mutations in either well-known oncogenes or tumor-suppressor genes that frequently occur in CRC, the researchers say.

"We found that miR-135b is up-regulated in both sporadic and inflammatory bowel disease-associated colorectal cancer, and that its up-regulation is associated with tumor stage and poor clinical outcome," says principal investigator Carlo M. Croce, MD, chair of molecular virology, immunology and medical genetics, and director of Human Cancer Genetics at Ohio State and the OSUCCC James.

"Our findings provide proof-of-principle that anti-miR-135b has significant therapeutic potential in colorectal cancer treatment," says Croce, who is also the John W. Wolfe Chair in Human Cancer Genetics.

For this study, Croce and his collaborators used a CRC mouse model based on loss of a tumor suppressor and a model based on inflammation and oncogene activation; human tumors from a cohort of sporadic CRC and inflammatory-bowel-disease associated CRC; human and animal cell lines and data from The Cancer Genome Atlas.

Key findings included:

  • MiR-135b up-regulation occurs in both sporadic and inflammatory bowel disease-associated CRC, and it is associated with tumor
    '/>"/>

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Wexner Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Study gives high marks to NC Pre-K program
2. Proteomics International biomarker study closer to a CDx test for diabetic kidney disease
3. Study links domestic abuse to mental health problems in new mothers
4. Empowerment program greatly decreases incidence of rape, Stanford/Packard-led study finds
5. Lipid levels during prenatal brain development impact autism: York U study
6. ED dental care treatment raises access, cost issues for policymakers, Rutgers study finds
7. $2.5 million Defense Department grant funds gene therapy study for Lou Gehrigs disease
8. Study finds link between childs obesity and cognitive function
9. Study reveals animal research bias in experimentation oversight committee membership
10. Fruitfly study: Epilepsy drug target implications for sleep disruption in brain disorders
11. Obesity primes the colon for cancer, according to NIH study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/4/2015)... 04, 2015 Dr. Richard Champagne, DMD, ... chosen to receive the America’s Best Dentist Award, given ... selection as a top dentist is a reflection of ... education and his compassion for his patients. , Each ... exemplify excellence in their field. These nominees are dentists ...
(Date:5/4/2015)... Sylvia Hawthorn-Deppen shared her experiences living with ... others in similar situations that they were not alone, in ... Discovery of New Energy” (published by Balboa Press). This year ... renewed press campaign. , “I have spent nearly 60 years ... says. “As an adolescent I got into trouble with an ...
(Date:5/4/2015)... Vista, California (PRWEB) May 04, 2015 ... introduced a brand new lubricant -- Astroglide TTC™ ... impede sperm motility and alter pH levels, Astroglide TTC™ ... conception. , According to the Centers for Disease ... have trouble getting pregnant or sustaining a pregnancy, ...
(Date:5/4/2015)... 04, 2015 “ Food Cost Calculator ” ... which takes a look at the latest and coolest applications ... the host of AppWatch and technology expert, conducted the app ... owners to manage and efficiently calculate food costs. , The ... In fact, the industry has an estimated 1.8 trillion dollar ...
(Date:5/4/2015)... (PRWEB) May 04, 2015 ... just released the first-ever congenital heart disease ... Catheterization Laboratory (PCCL) accreditation. Driven by the ... are a comprehensive review of interventional procedures ... heart disease. , “The ACE CHD Standards ...
Breaking Medicine News(10 mins):Health News:New Jersey Dentist Dr. Richard Champagne Nominated for America’s Best Dentist Award 2Health News:Author launches new press campaign for 2012 book ‘Wheel’ 2Health News:Astroglide Announces the Birth of Its New Baby: Astroglide TTC 2Health News:Astroglide Announces the Birth of Its New Baby: Astroglide TTC 3Health News:An Application to Manage a Successful Restaurant Was Featured on NewsWatch Television 2Health News:Accreditation for Cardiovascular Excellence (ACE) Publishes New Standards for Pediatric and Adult Congenital Cardiac Catheterization Laboratories 2
... CLEVELAND, Feb. 4 Franklin & Seidelmann,( ... market penetration into the hospital sector with the,addition of ... , , -- Barnes-Kasson Hospital, Susquehanna, ... Owenton, KY, -- Syringa General Hospital, ...
... Kensey Nash Corporation (Nasdaq: KNSY ), a leading ... a wide range of medical procedures, today announced the resignation ... Ramius LLC, from its Board of Directors.Mr. Smith became a ... member of the Corporate Governance and Nominating Committee as well ...
... counterfeit and adulterated medicines posing an increasing risk to ... Pharmacopeial (USP) Convention today announces new standards for two ... episodes of adulteration resulting in patient deaths. , ... heparin and the sweetener glycerin, comes on the heels ...
... Impacts One in Four Americans Show Features Real People with ... Bob Schieffer and Denver Broncos, Quarterback Jay CutlerWESTPORT, Conn., Feb. ... today the new 2009 television schedule for dLifeTV ... people living with diabetes, airing every Sunday on CNBC at ...
... U.S. Preventive Medicine(R), the leader in disease prevention ... Christopher Fey, Chairman and CEO, and Fred Goldstein, President ... Services Conference, to be held February 9-11 in New ... U.S. Preventive Medicine will participate in this exclusive conference ...
... and special product offerings available in store during ... CVS/pharmacy, America,s largest retail pharmacy, will mark American ... about maintaining heart health and preventing heart disease. ... month on many heart health-related products.Heart disease is ...
Cached Medicine News:Health News:Franklin & Seidelmann Expands into Critical Access Hospital Market Provides 24 x 7 Teleradiology Service for Three New Clients 2Health News:Franklin & Seidelmann Expands into Critical Access Hospital Market Provides 24 x 7 Teleradiology Service for Three New Clients 3Health News:Kensey Nash Announces Director Resignation 2Health News:USP announces new standards to protect patients from counterfeit and adulterated medicines 2Health News:dLifeTV Announces New Season Programming and Celebrity Guests; Only Nationally-Broadcast Program About Diabetes Celebrates 5th Year and 200th Show 2Health News:dLifeTV Announces New Season Programming and Celebrity Guests; Only Nationally-Broadcast Program About Diabetes Celebrates 5th Year and 200th Show 3Health News:U.S. Preventive Medicine(R) Executives to Present at 2009 UBS Global Healthcare Services Conference 2Health News:CVS/pharmacy Taking Health to Heart in February 2Health News:CVS/pharmacy Taking Health to Heart in February 3
(Date:5/4/2015)... , May 4, 2015 RadiologyAuction will have their ... video and product demonstrations at the end of the ... such as Kodak and Fuji Cr,s, Agfa and Sony, ... the first event. Various imaging equipment will be available ... After years of buying and selling imaging ...
(Date:5/4/2015)... , May 4, 2015  Oncobiologics, Inc., a ... antibody (mAb) biosimilars, has completed the construction of ... headquarters in Cranbury, New Jersey ... facility is designed to utilize multiple technologies ... commercial scale.  Through the use of the latest ...
(Date:5/4/2015)... CARLSBAD, Calif. , May 4, 2015  Isis ... an exclusive license agreement with Bayer HealthCare (Bayer) to ... of thrombosis. Under the terms of the agreement, Isis ... near-term payments, including an immediate $100 million up-front payment ... program following a Phase 2 study in patients with ...
Breaking Medicine Technology:RadiologyAuction Announces Event Starting On May 5th 2Oncobiologics opens commercial launch manufacturing facility in Cranbury, New Jersey 2Oncobiologics opens commercial launch manufacturing facility in Cranbury, New Jersey 3Isis Pharmaceuticals Licenses ISIS-FXI Rx to Bayer to Develop and Commercialize for the Prevention of Thrombosis 2Isis Pharmaceuticals Licenses ISIS-FXI Rx to Bayer to Develop and Commercialize for the Prevention of Thrombosis 3Isis Pharmaceuticals Licenses ISIS-FXI Rx to Bayer to Develop and Commercialize for the Prevention of Thrombosis 4Isis Pharmaceuticals Licenses ISIS-FXI Rx to Bayer to Develop and Commercialize for the Prevention of Thrombosis 5
... , NEW YORK, Nov. 19 As ... is here. Here,s more on preparing yourself. , Listen to ... http://inr.mediaseed.tv/oneClip_C/?feed=ksLp_frMYEE7RzdnRfCsbxc9R2VXAOIF , Medialink is a division ... text, graphics and photos at http://www.thenewsmarket.com . ...
... , , NEWPORT NEWS, Va., Nov. 19 ... recognized and endorsed by two highly esteemed organizations for ... Imaging (SBI) and the American College of Surgeons. Both ... breakthrough imaging technology for the early detection of breast ...
Cached Medicine Technology:Esteemed Endorsements Recognize Promising Future of Breast-Specific Gamma Imaging (BSGI) 2Esteemed Endorsements Recognize Promising Future of Breast-Specific Gamma Imaging (BSGI) 3
The New Vantage Plus. The PLUS gives you: ,P Premium intelligent optics ,L Lighter weight and brighter images ,U Unique wireless patented technology ,S Smaller and more compact size ...
STAT-CRIT is a rapid, one-step system for measuring hematocrit....
... Simple, compact, and easy to use, ... surgery technology to every OR. The business ... provide hospitals and surgeons with the most ... their facilities. ,The z-boxTM is designed to ...
...
Medicine Products: