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Study highlights from November issue of GIE: Gastrointestinal Endoscopy
Date:11/23/2009

searchers at the Institute Paoli-Calmettes, Marseilles, France, set out to determine the value of EUS-FNA for the diagnosis of PETs and for classifying the underlying malignant potential of these tumors based on the proposed World Health Organization (WHO) classification. Although EUS-FNA is often used for diagnosing PET, there are no data on its accuracy in determining the malignant potential of PETs and in applying the WHO classification. This single-center, retrospective cohort study, the largest experience of EUS-FNA in the diagnosis of PET, involved 86 patients who had been diagnosed with PETs and submitted to EUS-FNA from January 1999 to August 2008.

Overall, in 90 percent of patients in this study, PET was diagnosed with EUS-FNA. The sensitivity did not vary with tumor size, type, location, or the presence of hormonal secretion. Of 86 patients, 35 percent were submitted to surgical resection. There was a fair correlation between the WHO classification obtained by EUS-FNA and that obtained by surgery in the 24 patients who had records on both procedures available. All 10 patients classified as having an endocrine carcinoma (cancer) by EUS-FNA had the diagnosis confirmed by surgery. The five-year survival rates were 100 percent for endocrine tumors, 68 percent for well-differentiated endocrine carcinomas, and 30 percent for poorly differentiated endocrine carcinomas.

The researchers concluded that EUS-FNA is a safe and highly accurate technique for diagnosing PET and that it is possible to determine the potential malignant behavior of a PET in specimens obtained byEUS-FNA by applying the WHO classification. EUS-FNA findings predict five-year survival in patients with PET and this may help to better guide the therapeutic approach for these patients.

"EUS in pediatric patients"

Although the role of EUS is well established in adult gastrointestinal (GI) and pacreatobiliary (pancreas, bile ducts, gallbladder) disease, knowl
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Contact: Anne Brownsey
abrownsey@asge.org
630-570-5635
American Society for Gastrointestinal Endoscopy
Source:Eurekalert

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