Navigation Links
Study helps explain increased melanoma risk in individuals with red hair
Date:8/22/2013

In this current study, Wei and Cui wanted to find out how this was happening.

Led by co-first authors, Lixin Wan, PhD, a member of the Wei laboratory at BIDMC and Juxiang Cao, PhD, a member of the Cui lab at BUSM, the scientific team embarked on a series of experiments in both cell cultures and mouse models. Their experiments showed that in normal circumstances, MC1R was binding to PTEN, a well-known tumor suppressor gene. PTEN acts to safeguard against cancer; without PTEN, the end result is elevated signaling in the cancer-causing P13K/Akt pathway.

The team then went on to demonstrate that MC1R-RHC mutations found in red-haired individuals lacked this protective mechanism. "As a result, upon UVB exposure, we saw an increased destruction of PTEN in the mutated pigment cells," says Wei. The team additionally found that in these same MC1R-RHC pigment cells, elevated PI3K/Akt activity was boosting cell proliferation and was synchronizing with another well-known cancer mutation in the BRAF gene (found in nearly 70 percent of human melanomas) to further accelerate cancer development. In support of these results, note Wei and Cui, another research group at Massachusetts General Hospital recently demonstrated that expression of the BRAF gene mutation in the melanocytes of mice carrying a mutated MC1R gene led to a high incidence of invasive melanomas.

"Together, our findings provide a possible molecular mechanism as to why red-haired individuals harboring MC1R mutations are much more susceptible to UV-induced skin damage than individuals with darker skin, resulting in a 10-to100-fold higher frequency of melanoma," says Wei.

The authors note that this newly established link between MC1R and PTEN will be a starting point for future studies, adding that it remains unclear why only MC1R genetic variants linked to the red hair phenotype but not all MC1R variants are unable to bind to PTEN following UV exposure.

"We think that
'/>"/>

Contact: Bonnie Prescott
bprescot@bidmc.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. UCLA Nursing study suggests focus on lifestyle changes -- not weight loss -- is key to kids health
2. Study finds grandmothers who raise their grandkids struggle with depression
3. Study: Disease caused by repeat brain trauma in athletes may affect memory, mood, behavior
4. Case study collection diagnostic dilemmas hones physicians skills
5. Shocking New CDC Study Confirms U.S. Tick-Borne Disease Epidemic, Shows Lyme Disease Rates 10X Higher than Previously Reported
6. Penn Medicine study shows survivorship care plans empower cancer patients
7. UCLA study suggests iron is at core of Alzheimers disease
8. Brain cancer survival improved following FDA approval of bevacizumab, Mayo study finds
9. The concussed brain at work: fMRI study documents brain activation during concussion recovery
10. Newest Bard IVC Filter Failure Lawsuit Allegations Update: Resource4thePeople Urges Consumers to Review FDA, Research Study Findings about Adverse Events
11. Longest and largest study of insulin pumps to treat type 1 diabetes in children shows they control blood sugar more effectively and with fewer complications than injections
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/22/2014)... Visitors to the Radiometer booth (#331) at the ... have the opportunity to learn from the company’s experts ... host two sessions of each presentation at the following ... Plan (IQCP) for Blood Gas Testing, Tuesday, July 29, ... Clinical and Scientific Affairs Manager, Radiometer America , The ...
(Date:7/22/2014)... July 22, 2014 BlackBox Biometrics, Inc. ... Gauge™ System with advancements including a new ... gauges represent a functional revision of the already robust ... capture complex data on blast events by recording a ... The extreme changes in overpressure that accompany a blast ...
(Date:7/22/2014)... 22, 2014 Eating certain foods can not ... well, according to two of the world’s top cosmetic ... Reshad of the Anacapa Dental Art Institute in Oxnard and ... care of one’s teeth. They are specially trained to replace ... are not seeing a dentist regularly, and about two-thirds of ...
(Date:7/22/2014)... Alan Tonelson of Riverdale Park, Md. ... most kids outgrow the inhibiting speech condition by the ... the three million people in the U.S. who live ... Throughout his youth, he participated in a variety of ... with private speech-and-language pathologists. None helped him achieve fluency. ...
(Date:7/22/2014)... Recently, 2014quinceaneradresses.com, a popular online shop of women’s ... blue and white Quinceanera dresses . Moreover, the ... gowns, hoping to show appreciation to the international clients. ... discounted price, up to 60% off. , Its ... items. As one of the leaders in the fashion ...
Breaking Medicine News(10 mins):Health News:Radiometer Features Booth Presentations On IQCP and Blood Gas Preanalytics at the 2014 AACC Clinical Lab Expo 2Health News:BlackBox Biometrics®, Inc. continues to advance blast overpressure measurement with release of new Blast Gauge 2Health News:BlackBox Biometrics®, Inc. continues to advance blast overpressure measurement with release of new Blast Gauge 3Health News:Ventura’s Best Cosmetic Dentists Offer 4 Tips for Improving Dental Health Through Nutrition 2Health News:Ventura’s Best Cosmetic Dentists Offer 4 Tips for Improving Dental Health Through Nutrition 3Health News:Ventura’s Best Cosmetic Dentists Offer 4 Tips for Improving Dental Health Through Nutrition 4Health News:Ventura’s Best Cosmetic Dentists Offer 4 Tips for Improving Dental Health Through Nutrition 5Health News:New Steps in the “Ballet of Speech” Create Life-Changing Possibilities for People Who Stutter 2Health News:New Steps in the “Ballet of Speech” Create Life-Changing Possibilities for People Who Stutter 3Health News:New Steps in the “Ballet of Speech” Create Life-Changing Possibilities for People Who Stutter 4Health News:Blue and White Quinceanera Dresses at Low Prices Offered by 2014quinceaneradresses.com 2
... , CHICAGO, Sept. 1 In ... which shows young athletes with repeated brain injuries are at ... Association (IATA) and the Chicago Institute of Neurosurgery and Neuroresearch ... and monitoring concussions. The complimentary card is an educational tool ...
... , , , FRANKLIN LAKES, N.J., Sept. 1 ... announced today that it would present at the following investor healthcare conferences in September: , ... September 9, 2009, ... Conference, September 14, 2009, ...
... than laparoscopic surgery, study finds , TUESDAY, Sept. 1 ... pelvic pain by disrupting nerve connections failed to improve ... researchers say. , The nerve-disruption procedure "did not alleviate ... irrespective of the presence or absence of mild endometriosis," ...
... , , WARSAW, Ind., Sept. 1 Zimmer ... be participating in the following investor conferences during the month of September: , ... Conference 2009 in Boston, Mass., on September 9, 2009, at 11:30 a.m. Eastern ... New York, N.Y., on September 14, 2009, at 8:35 a.m. Eastern Time; and ...
... "Saturday ... Dr. Lonnie Paulos now beginning its second year , ... Gulf Breeze, FL (Vocus) September 1, 2009 -- ... orthopaedic exams and assessments to high school and collegiate athletes on Saturday mornings. ...
... , KANSAS CITY, Mo., Sept. 1 ... with medical challenges often unique to members of the military. From ... some of the most pressing conditions confronting the health care system ... Release, go to: http://www.prnewswire.com/mnr/militaryhealth/39824/ , ...
Cached Medicine News:Health News:Illinois Athletic Trainers and Physicians Offer Handy Wallet Card to Tackle Concussions 'Head On' 2Health News:Two Treatments Equally Effective for Chronic Pelvic Pain 2Health News:Andrews Institute for Orthopaedics and Sports Medicine Now Providing Free Orthopaedic Exams and Assessments on Saturday Mornings to Student Athletes 2Health News:Andrews Institute for Orthopaedics and Sports Medicine Now Providing Free Orthopaedic Exams and Assessments on Saturday Mornings to Student Athletes 3Health News:Video: Physical and Mental Health of U.S. Warfighter Is Focus of Military Health Research Forum 2
(Date:7/22/2014)... MARCOS, Texas , July 22, 2014 Quantum Materials ... and Mr. John Heaton to the Board of ... by Dr. Ghassan Jabbour , QMC Chief Science Officer and ... Michael Wong of Rice University and Mr. Tomio ... Japan . " Quantum Materials welcomes ...
(Date:7/22/2014)... WASHINGTON, New York , July ... Neue Partnerschaft für umfassenden Schutz ... Medikamenteneinwirkungen in Österreich    ... Anbieter von geschlossenen Transfersystemen (Closed System Transfer Devices, CSTDs) ... Medikus , einen Vertriebshändler und Hersteller ...
(Date:7/22/2014)... July 22, 2014 ... company focused on solid dose formulations of therapeutics ... formulation of octreotide acetate achieved successful results in ... currently marketed liquid product (Sandostatin®).  Based on these ... production process to a contract manufacturing organisation (CMO), ...
Breaking Medicine Technology:Quantum Materials Announces New Outside Directors and Adds Scientific Advisory Board 2Quantum Materials Announces New Outside Directors and Adds Scientific Advisory Board 3Quantum Materials Announces New Outside Directors and Adds Scientific Advisory Board 4Equashield ernennt Medikus zu seinem exklusiven österreichischen Vertriebspartner für seine geschlossenen Arzneimitteltransfersysteme 2Glide Pharma Completes Successful Proof-of-Concept Study with Novel Solid Dose Formulation of Octreotide 2
... Biotech Inc. ("Oncolytics") (TSX:ONC, NASDAQ: ONCY ) ... in a Phase 2 clinical trial using intravenous ... carboplatin in patients with non-small cell lung cancer ... Investigator is Dr. Miguel Villalona-Calero, Professor, Division of ...
... The following is being issued by Coast IRB: ... 2009, Coast IRB informed the public that it had discovered ... that Independent review board for evaluation. Coast IRB has ... part of a congressional "sting" operation. Apparently at the ...
Cached Medicine Technology:Oncolytics Biotech(R) Inc. Announces Start of Enrolment in U.S. Phase 2 Combination Clinical Trial for Non-Small Cell Lung Cancer Patients with K-RAS or EGFR-Activated Tumours 2Congressional 'Sting' Operation Uncovered By Coast IRB 2
These retractors are packaged singly ready for sterilization at your facility....
... is a revolutionary motorized electronic pipette. ... mind, Pipetman Concept features exclusive multifunction ... only one of its kind in ... Tips from Gilson, this product will ...
Rainbow technology combines the latest in system theory, adaptive signal processing and a revolutionary sensor that employs eight wavelengths of light to collect and analyze an extraordinarily rich s...
... is a revolutionary motorized electronic pipette. ... mind, Pipetman Concept features exclusive multifunction ... only one of its kind in ... Tips from Gilson, this product will ...
Medicine Products: