Navigation Links
Study helps explain increased melanoma risk in individuals with red hair
Date:8/22/2013

In this current study, Wei and Cui wanted to find out how this was happening.

Led by co-first authors, Lixin Wan, PhD, a member of the Wei laboratory at BIDMC and Juxiang Cao, PhD, a member of the Cui lab at BUSM, the scientific team embarked on a series of experiments in both cell cultures and mouse models. Their experiments showed that in normal circumstances, MC1R was binding to PTEN, a well-known tumor suppressor gene. PTEN acts to safeguard against cancer; without PTEN, the end result is elevated signaling in the cancer-causing P13K/Akt pathway.

The team then went on to demonstrate that MC1R-RHC mutations found in red-haired individuals lacked this protective mechanism. "As a result, upon UVB exposure, we saw an increased destruction of PTEN in the mutated pigment cells," says Wei. The team additionally found that in these same MC1R-RHC pigment cells, elevated PI3K/Akt activity was boosting cell proliferation and was synchronizing with another well-known cancer mutation in the BRAF gene (found in nearly 70 percent of human melanomas) to further accelerate cancer development. In support of these results, note Wei and Cui, another research group at Massachusetts General Hospital recently demonstrated that expression of the BRAF gene mutation in the melanocytes of mice carrying a mutated MC1R gene led to a high incidence of invasive melanomas.

"Together, our findings provide a possible molecular mechanism as to why red-haired individuals harboring MC1R mutations are much more susceptible to UV-induced skin damage than individuals with darker skin, resulting in a 10-to100-fold higher frequency of melanoma," says Wei.

The authors note that this newly established link between MC1R and PTEN will be a starting point for future studies, adding that it remains unclear why only MC1R genetic variants linked to the red hair phenotype but not all MC1R variants are unable to bind to PTEN following UV exposure.

"We think that
'/>"/>

Contact: Bonnie Prescott
bprescot@bidmc.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. UCLA Nursing study suggests focus on lifestyle changes -- not weight loss -- is key to kids health
2. Study finds grandmothers who raise their grandkids struggle with depression
3. Study: Disease caused by repeat brain trauma in athletes may affect memory, mood, behavior
4. Case study collection diagnostic dilemmas hones physicians skills
5. Shocking New CDC Study Confirms U.S. Tick-Borne Disease Epidemic, Shows Lyme Disease Rates 10X Higher than Previously Reported
6. Penn Medicine study shows survivorship care plans empower cancer patients
7. UCLA study suggests iron is at core of Alzheimers disease
8. Brain cancer survival improved following FDA approval of bevacizumab, Mayo study finds
9. The concussed brain at work: fMRI study documents brain activation during concussion recovery
10. Newest Bard IVC Filter Failure Lawsuit Allegations Update: Resource4thePeople Urges Consumers to Review FDA, Research Study Findings about Adverse Events
11. Longest and largest study of insulin pumps to treat type 1 diabetes in children shows they control blood sugar more effectively and with fewer complications than injections
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/14/2014)... treat children with uncomplicated acute appendicitis is a reasonable ... fewer missed school days, according to a pilot study. ... Hospital and published online April 12 in the ... the first prospective study on nonoperative management of acute ... , Researchers enrolled 77 patients age 7 to 17 ...
(Date:4/14/2014)... 2014, Perth, Australia. Drug discovery company Proteomics International ... of a companion diagnostic (CDx) test with the ... The research team authenticated the panel of biomarkers ... samples. Seven biomarkers were validated at high stringency ... The mass spectrometry data was then cross-validated using ...
(Date:4/14/2014)... 2014) When it comes to the cost and ... Patients get the best care when they are treated ... extensive experience in their current job, according to a ... and Columbia Business School. The study was published in ... Applied Economics . , The review of more ...
(Date:4/13/2014)... STANFORD, Calif. A low-cost empowerment program for ... and sexual harassment of these girls, who live ... and are frequently attacked, a large new study ... Stanford University School of Medicine, Lucile Packard Children,s ... No Worldwide, validated the program,s effectiveness in combating ...
(Date:4/11/2014)... the processes that control brain cell production could pave ... brain-related disorders. , Scientists have gained new understanding of ... how and when nerve and brain cells are formed ... and keeps it healthy. Their findings could help explain ... which is a fundamental characteristic of many diseases including ...
Breaking Medicine News(10 mins):Health News:Antibiotics alone are a successful treatment for uncomplicated acute appendicitis in kids 2Health News:Antibiotics alone are a successful treatment for uncomplicated acute appendicitis in kids 3Health News:Longer nurse tenure on hospital units leads to higher quality care 2Health News:Empowerment program greatly decreases incidence of rape, Stanford/Packard-led study finds 2Health News:Empowerment program greatly decreases incidence of rape, Stanford/Packard-led study finds 3Health News:Empowerment program greatly decreases incidence of rape, Stanford/Packard-led study finds 4
... Could one day lead to treatments for baldness, researchers ... have taken a step forward in understanding the mechanisms ... some women, for all of history: hair loss. , ... hair follicles to start the hair-growing cycle. , "These ...
... Mylan Inc. (NYSE: MYL ),today announced that ... company has declared its quarterly dividend of $16.25 per,share ... a liquidation,preference of $1,000.00 per share) payable on August ... of August 1, 2008., Mylan Inc., with operations ...
... ATRC ), a medical device company and a leader in ... following,investor conferences during August:, -- The BMO Focus on ... the Millennium Broadway Hotel in New York. David J. Drachman, President ... present at 9:00 a.m. Eastern time., ...
... State of Michigan to spray the state,s apple orchards ... antibiotic to treat blood infections in newborns and other ... of America (IDSA). , The Environmental Protection Agency ... permission to use gentamicin to fight a tree disease ...
... Pat Phalin learned she had hearing loss at 30, ... school. The pupils heard sounds she could not hear. ... in his wife,s family history. Her mother, grandfather and great-grandfather ... children had hearing problems before he reached school age. ...
... 31, 2008 The AMERIGROUP Foundation, the,philanthropic arm ... for Children,s (UMHC) Breathmobile at a ceremony today ... Maryland Chief Operating Officer Vince Ancona presented a,contribution ... the AMERIGROUP,Foundation. The UMHC Breathmobile is a custom-built ...
Cached Medicine News:Health News:Mouse Study Finds Molecule That Tells Hair to Grow 2Health News:AtriCure to Present at the BMO Focus on Healthcare and Canaccord Adams Global Growth Conferences in August 2Health News:Physicians ask EPA, 'Antibiotics to cure sick apples, or sick children?' 2Health News:Inherited form of hearing loss stems from gene mutation 2Health News:Inherited form of hearing loss stems from gene mutation 3Health News:The AMERIGROUP Foundation Honors the University of Maryland Hospital for Children's Breathmobile 2
(Date:1/15/2014)... 15, 2014  Research and Markets ( http://www.researchandmarkets.com/research/6k27gw/dental ... "Dental Consumables Market - Global Industry Analysis, Size, ... report to their offering. ... Dental consumables are products which are used on ... tooth restoration and in treatment of associated gingival ...
(Date:1/15/2014)... LAWRENCEVILLE, N.J. , Jan. 15, 2014  Celsion ... today announced that it has received commitments from ... $15 million of the Company,s common stock in ... dedicated health care fund. The Company ... pursuant to which the Company agreed to sell ...
(Date:1/15/2014)... -- BreedIT Corp (OTC: BRDT), through its ... highly sophisticated agro-breeding solutions for plant breeders and researchers, ... board of directors appointed chemistry and pharmaceutical industry expert ... of the board. From 1975 to 2012, ... Ltd (NYSE: TEVA ) and its subsidiaries ...
Breaking Medicine Technology:Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 2Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 3Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 2Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 3BreedIT (OTC: BRDT) Appoints Chemistry and Pharmaceutical Industry Expert Dr. Ben-Zion Weiner to Its Board of Directors 2BreedIT (OTC: BRDT) Appoints Chemistry and Pharmaceutical Industry Expert Dr. Ben-Zion Weiner to Its Board of Directors 3
... 2011 Hospira, Inc. (NYSE: HSP ), a ... that it will host a conference call to discuss its ... a.m. Central time. The company will release its ... open and the conference call. A live webcast ...
... DEL REY, Calif., April 4, 2011 Dr. Richard Merkin, ... official launch of the $3 million dollar Heritage Health Prize, ... celebrating the launch of the contest at the Data 2.0 ... interest in data mining and analytics to enter the $3 ...
Cached Medicine Technology:Heritage Provider Network Announces the Official Launch of the $3 million Dollar Heritage Health Prize 2Heritage Provider Network Announces the Official Launch of the $3 million Dollar Heritage Health Prize 3
... TC-PLUS Solution tricompartmental total knee prosthesis stems ... arthroplasty. State-of-the-art design and manufacturing technologies have ... biomechanical function as well as a favorable ... insert to keep wear to a minimum. ...
... The TC-PLUS Solution tricompartmental total knee prosthesis ... knee arthroplasty. State-of-the-art design and manufacturing technologies ... optimum biomechanical function as well as a ... tibial insert to keep wear to a ...
... Knee System is a long term, quality ... Available in both posterior stabilized and anatomically ... System provides the flexibility needed to address ... ease of identification keeps the user in ...
... a long term, quality solution based on ... posterior stabilized and anatomically correct cruciate retaining ... flexibility needed to address patients' needs. In ... keeps the user in mind and promotes ...
Medicine Products: