Navigation Links
Study helps explain how pathogenic E. coli bacterium causes illness
Date:3/14/2011

Scientists at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, have shown how the O157:H7 strain of Escherichia coli causes infection and thrives by manipulating the host immune response. The bacterium secretes a protein called NleH1 that directs the host immune enzyme IKK-beta to alter specific immune responses. This process not only helps the bacterium evade elimination by the immune system, it also works to prolong the survival of the infected host, enabling the bacterium to persist and ultimately spread to unaffected individuals. This finely balanced mechanism, observed in both laboratory and animal models, could be relevant to other pathogens involved in foodborne diseases.

While most E. coli strains help check the growth of harmful bacteria in the guts of animals and humans, a few E. coli strains, such as O157:H7, can cause severe diarrhea, abdominal cramps and, in rare cases, death. Human cases of E. coli O157:H7 have been linked to consumption of raw, undercooked, or spoiled meat.

NIAID researchers plan to use the new information to further study how the host immune system mounts a response to E. coli O157:H7 when infection begins and how the bacterium selectively blocks these defenses. Several foodborne pathogens, including Shigella and Salmonella, use a similar secretion system to disrupt host immune responses and infect gut cells.


'/>"/>

Contact: NIAID Office of Communications
niaidnews@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Page: 1

Related medicine news :

1. Study seeks to halt progression of diabetic nephropathy
2. Neuro signals study gives new insight into brain disorders
3. Text Messages May Help Smokers Kick the Addiction, Small Study Finds
4. Adults With HIV at Increased Risk of Bone Fractures, Study Finds
5. New study shows government spending preferences of Americans
6. Wayne State study links testosterone with mens ability to woo potential mates
7. Depression Seems to Increase Risk of Kidney Failure: Study
8. UTHealth study: Stem cells may provide treatment for brain injuries
9. Humans Age at Same Pace as Other Primates, Study Finds
10. Poor Diet in Pregnancy Tied to Disease in Offspring: Rat Study
11. Animal Study May Explain Low Birth Weight-Obesity Link
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/16/2017)... Angeles, California (PRWEB) , ... August 16, 2017 , ... An August 3rd article ... that was the subject of a report in JAMA (the Journal of the American Medical ... above 50 were able to achieve BMIs under 30, when compared to patients with lower ...
(Date:8/16/2017)... FL (PRWEB) , ... August 16, 2017 , ... ... standardized product data and images announced today that it was acquired by Advantage ... Industry’s solution for product information. IX-ONE’s members include the industry’s leading suppliers, brokers, ...
(Date:8/16/2017)... ... August 16, 2017 , ... In 1987, ... celebrate 30 years in business this year, and they’re marking the milestone by ... to serve their patients. , It stands to reason that, given the ...
(Date:8/16/2017)... ... August 16, 2017 , ... Modern Consulting Insurance & ... program. Partnering once again with Boys & Girls Clubs of Greater Kansas City, ... area’s very own American Idol. With all proceeds benefitting local worthy causes, donations ...
(Date:8/16/2017)... ... August 16, 2017 , ... Paul Vitenas, MD, FACS ... 2017 Top Doctor. The annual list identifies the nation’s top physicians, in a variety ... made it to the top of Castle Connolly’s coveted ranking. , Castle Connolly is ...
Breaking Medicine News(10 mins):
(Date:8/14/2017)... HACKENSACK, N.J. and PETACH TIKVAH, ... Therapeutics Inc. (NASDAQ: BCLI), a leading developer of adult ... for the second quarter ending June 30, 2017. ... advanced stages of preparing for our pivotal Phase 3 ... Chaim Lebovits , President and Chief Executive Officer ...
(Date:8/7/2017)... Md. , Aug. 7, 2017 ... healthcare member acquisition, retention, and engagement, announced the ... of Strategy and Product Development, effective as of ... consulting and technology implementation strategy for our clients. ... of experience in consulting and business analytics within ...
(Date:8/4/2017)... -- The search for test results that can be ... long been the goal of healthcare providers and the ... largest meeting of lab professionals and IVD firms this ... Kalorama Information.  The firm said scores of companies with ... and software were at the American Association for Clinical ...
Breaking Medicine Technology: