Navigation Links
Study helps explain how pathogenic E. coli bacterium causes illness
Date:3/14/2011

Scientists at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, have shown how the O157:H7 strain of Escherichia coli causes infection and thrives by manipulating the host immune response. The bacterium secretes a protein called NleH1 that directs the host immune enzyme IKK-beta to alter specific immune responses. This process not only helps the bacterium evade elimination by the immune system, it also works to prolong the survival of the infected host, enabling the bacterium to persist and ultimately spread to unaffected individuals. This finely balanced mechanism, observed in both laboratory and animal models, could be relevant to other pathogens involved in foodborne diseases.

While most E. coli strains help check the growth of harmful bacteria in the guts of animals and humans, a few E. coli strains, such as O157:H7, can cause severe diarrhea, abdominal cramps and, in rare cases, death. Human cases of E. coli O157:H7 have been linked to consumption of raw, undercooked, or spoiled meat.

NIAID researchers plan to use the new information to further study how the host immune system mounts a response to E. coli O157:H7 when infection begins and how the bacterium selectively blocks these defenses. Several foodborne pathogens, including Shigella and Salmonella, use a similar secretion system to disrupt host immune responses and infect gut cells.


'/>"/>

Contact: NIAID Office of Communications
niaidnews@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Page: 1

Related medicine news :

1. Study seeks to halt progression of diabetic nephropathy
2. Neuro signals study gives new insight into brain disorders
3. Text Messages May Help Smokers Kick the Addiction, Small Study Finds
4. Adults With HIV at Increased Risk of Bone Fractures, Study Finds
5. New study shows government spending preferences of Americans
6. Wayne State study links testosterone with mens ability to woo potential mates
7. Depression Seems to Increase Risk of Kidney Failure: Study
8. UTHealth study: Stem cells may provide treatment for brain injuries
9. Humans Age at Same Pace as Other Primates, Study Finds
10. Poor Diet in Pregnancy Tied to Disease in Offspring: Rat Study
11. Animal Study May Explain Low Birth Weight-Obesity Link
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/6/2016)... ... February 06, 2016 , ... ... MEDIA ADVISORY: 5000 PERIOPERATIVE NURSES EXPECTED AT AORN SURGICAL CONFERENCE & EXPO ... in the world with an estimated 5000 perioperative nurses in attendance to ...
(Date:2/5/2016)... ... February 05, 2016 , ... Steven Tonkinson, 36, of ... completed every year since it started in 2003. This year, he ran all 26.2 ... fellow runners and NBA team the Miami Heat. , This Sunday, while many are ...
(Date:2/5/2016)... ... February 05, 2016 , ... The event is being held ... Event Center in Minneapolis, Minn. Triumph Over Parkinson’s will fund nearly $100,000 for research ... Schneiderman’s Furniture, lives with Parkinson’s disease and is the architect of this informative event ...
(Date:2/5/2016)... ... February 05, 2016 , ... After years as an active staff surgeon ... and cosmetic surgeon Dr. Wayne Carman transitioned to chief of the Division of Plastic ... first three-year term as chief and began a second three-year term in January of ...
(Date:2/5/2016)... York, New York (PRWEB) , ... February 05, 2016 , ... ... gym use and find themselves having to wait longer to access the treadmills. It’s ... their New Year’s resolutions to lose weight and get in shape by joining gyms, ...
Breaking Medicine News(10 mins):
(Date:2/4/2016)... Medical, Inc. (Nasdaq: AEMD ), the pioneer ... diseases, today announced results for the third quarter ... --> --> "Beyond ... quarterly call, we strategically advanced pre-clinical and clinical ... the Aethlon Hemopurifier® as a leading broad-spectrum countermeasure ...
(Date:2/4/2016)... N.Y. , Feb. 4, 2016  AMRI (NASDAQ:  AMRI) ... President of Pfizer Inc. and President of Pfizer Global Supply, ... as of February 4, 2016. In addition, the Company announced ... of the audit committee since 2010, has retired from the ... and attention to his other business ventures.  ...
(Date:2/4/2016)... PUNE, India , February 4, 2016 ... to the new Market Research Report "North American Automated ... and Fully-Automated External Defibrillators), by End-User (Public Facilities, Hospitals, ... North American automated external defibrillators (AED) report defines and ... of the revenue. This market is estimated to grow ...
Breaking Medicine Technology: