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Study helps explain fundamental process of tumor growth
Date:3/12/2008

rentially use glucose for purposes other than making adenosine triphosphate (ATP), the energy currency used by normal cells. We suspect that this mechanism evolved to ensure that fetal tissues only use glucose for growth when they are activated by appropriate growth factor receptor protein-tyrosine kinases, adds Cantley. By re-expressing PKM2, cancer cells acquire the ability to use glucose for anabolic processes.

Because PKM2 is found in all of the cancer cells that we have examined, because it is not found in most normal adult tissues, and because it is critical for tumor formation, this form of pyruvate kinase is a possible target for cancer therapy, he adds.


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Contact: Bonnie Prescott
bprescot@bidmc.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center
Source:Eurekalert

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