Navigation Links
Study helps explain fundamental process of tumor growth
Date:3/12/2008

se-hungry tumor cells, the areas of high glucose uptake are displayed dramatically on the PET scan.

Using a novel proteomic screen to identify new phosphotyrosine binding proteins, Cantley and his colleagues first determined that PKM2 can bind to phosphotyrosine-containing peptides. We observed that in contrast to the forms of pyruvate kinase found in most normal adult tissues, only PKM2, which is found in fetal cells, interacted with phosphotyrosine, explains Cantley. This finding was particularly interesting because previous reports had shown that this M2 form was the pyruvate kinase form used by all cancer cells.

In order to understand the implications of this discovery, Cantley and his coauthors next embarked upon experiments to evaluate the importance of PKM2 to cancer cells. Reasoning that tumor tissue switches pyruvate kinase expression from an adult M1 isoform to the embryonic M2 isoform, they performed immunoblotting and immunohistochemistry analysis of numerous cancer cell lines, breast cancer models and human colon cancer, confirming that PKM2 was the only form of pyruvate kinase found in cancerous tissue.

The authors then knocked down PKM2 expression in human cancer cell lines and expressed the adult M1 form instead. This switch from the fetal M2 form to the adult M1 isoform led to reduced lactate production and increased oxygen consumption a reversal of the Warburg effect.

We were able to show that only cells which express the M2 form of pyruvate kinase and metabolize glucose in the way described by Otto Warburg 80 years ago had the ability to form tumors in mice, notes Cantley. In addition, the investigators demonstrated that it is the ability of PKM2 to interact with phosphotyrosine that enables this form of pyruvate kinase to promote the unique glucose metabolism seen in cancer cells, thereby allowing these cells to make tumors in vivo.

The findings are consistent with the idea that tumor cells prefe
'/>"/>

Contact: Bonnie Prescott
bprescot@bidmc.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Protein deficiency leads to faster fat burning in mice, study shows
2. Study Finds Naturopathic Care for Chronic Low-Back Pain to be Efficacious, Cost-Effective
3. New AHIP Study in Health Affairs Challenges Previous Assumptions About Medigaps Impact on Medicare Costs
4. MHA to Release Findings of Independent Long Term Care Member Study
5. Henry Ford Hospital to study effectiveness of a new procedure that may help emphysema suffers
6. Radiologist Leora Lanzkowsky Study Suggests ...
7. Cepheid Comments on Study Regarding MRSA Surveillance Reported in the Journal of the American Medical Association
8. Life Recovery Systems Study of Heart Attack With ThermoSuit(R) System
9. Gender bias may affect care of people with osteoarthritis, study finds
10. Lung damage in babies with congenital heart disease under study
11. The hand cant be fooled, study shows
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2015)... 2015 Family, friends, students, colleagues, mentors ... oncologist, Dr. LaSalle D. Leffall, on Monday, May 18, ... after Grand Rounds in the hospital’s Tower Auditorium. Leffall’s ... the auditorium, trying to keep the secret. “I’d like ... sees me, he’ll know something is up,” she said. ...
(Date:5/22/2015)... Knoxville, TN (PRWEB) May 22, 2015 Power ... Andrew Drobeck for the 2015 race season. Drobeck is in ... also serves as a firefighter with the Missoula Fire Department ... and became a Pro in 2014. During his career, he ... as a Pro, Drobeck recorded top 10 finishes in all ...
(Date:5/22/2015)... Gateway Building Concepts is experienced with all forms of ... in include decks, additions, kitchen remodeling, interior renovations, exterior ... , The redesigned logo is a fresh modern ... includes two geometrical lines that represent the engineering aspect ... used with many things associated with the company. The ...
(Date:5/22/2015)... 22, 2015 DMG Productions announces the ... to broadcast on Friday, May 29, 2015 at 7:30 ... , In this episode Innovations will explore Interstate Restoration, ... business quickly through disaster recovery and restoration. , Additionally, ... works collaboratively to develop and deliver training and education ...
(Date:5/22/2015)... Co founders Greenlee and James Chapko, DDS ... dentists to immediately deliver fully integrated dental implant services to ... the medical surgeon. , The Center, whose name is ... dentists from placing dental implants. These 6 roadblocks can ... the surgical placement of dental implants into his or her ...
Breaking Medicine News(10 mins):Health News:Colleagues Surprise Dr. LaSalle Leffall with 85th Birthday Celebration 2Health News:New Episode of Innovations Airing Friday, May 29, 2015 Via Discovery Channel 2Health News:First of Its Kind Dental Implant Training and Surgicenter to Open in June 2
... , Researchers have undertaken a large-scale investigation ... protein (APP), a protein centrally associated with Alzheimer,s ... is the extracellular accumulation of amyloid plaques in ... cleavage of APP, which generates short, sticky fragments ...
... have identified a number of new genes that can ... that hopefully might be used to treat the disease ... These unique findings are being published in three ... Genetics. , SLE (systemic lupus erythematosus) is a so-called ...
... of Neurosciences at Mount Sinai School of Medicine have ... novel targeted gene therapy. In an effort to find ... Mount Sinai developed a gene therapy technique that simulates ... study Sensory neuron targeting by self-complementary AAV8 via lumbar ...
... 2007 An international research team, led by a ... (CHUM), has identified new therapeutic targets for the treatment ... Nature Immunology, the team provides fresh answers concerning the ... MS, a chronic autoimmune disease of the nervous system ...
... study says , , TUESDAY, Jan. 22 (HealthDay News) -- ,A ... liver cancer also increases the risk of developing high blood ... carefully monitored and treated, said the authors of a study ... Oncology . , Nexavar is an anti-angiogenesis drug, meaning it ...
... A new study reveals significant racial and ethnic differences ... sarcomas, a rare but dangerous cancer that begins in ... the body. The findings are published in the March ... the American Cancer Society. , While racial and ethnic ...
Cached Medicine News:Health News:Story ideas from Molecular and Cellular Proteomics 2Health News:Researchers find relief for chronic pain 2Health News:New therapeutic target for treatment of multiple sclerosis 2Health News:Liver Cancer Drug Raises Blood Pressure 2Health News:Disparities among patients with extremity soft-tissue sarcomas 2
(Date:5/22/2015)... 22, 2015 The Assistance Fund announces the ... provides financial assistance for copay to individuals diagnosed with ... the addition of the Melanoma Copay Assistance Program to ... , executive director. "With each additional program we are ... world where no one is denied access to medications ...
(Date:5/22/2015)... 22, 2015  The U.S. Food and Drug ... the first biosimilar product approved in ... growth in the contract manufacturing organization (CMO) industry, ... is geared to the production of small-molecular drugs ... products. The healthcare market research publisher,s report, ...
(Date:5/22/2015)... , May 20, 2015 Research and ... the "Guide to Prepare Application Dossiers for ... (2014 Edition) " report to their offering. ... one of segment market of the most growth ... medical device manufacturers and producers to penetrate such ...
Breaking Medicine Technology:The Assistance Fund Adds Melanoma Assistance Program 2Kalorama: First FDA-Approved Biosimilar Brings Hope for CMO Growth 2Kalorama: First FDA-Approved Biosimilar Brings Hope for CMO Growth 3Kalorama: First FDA-Approved Biosimilar Brings Hope for CMO Growth 4China Guide to Prepare Application Dossiers for Oversea Medical Device Registration and Recordation 2China Guide to Prepare Application Dossiers for Oversea Medical Device Registration and Recordation 3
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: