Navigation Links
Study helps clarify role of vitamin D in cancer therapy
Date:11/17/2008

A colon cancer cell isn't a lost cause. Vitamin D can tame the rogue cell by adjusting everything from its gene expression to its cytoskeleton. In the Nov. 17 issue of the Journal of Cell Biology, Ordez-Morn et al. show that one pathway governs the vitamin's diverse effects. The results help clarify the actions of a molecule that is undergoing clinical trials as a cancer therapy.

Vitamin D stymies colon cancer cells in two ways. It switches on genes such as the one that encodes E-cadherin, a component of the adherens junctions that anchor cells in epithelial layers. The vitamin also induces effects on the cytoskeleton that are required for gene regulation and short-circuiting the Wnt/b-catenin pathway, which is overactive in most colon tumors. The net result is to curb division and prod colon cancer cells to differentiate into epithelial cells that settle down instead of spreading.

To delve into the mechanism, the team dosed colon cancer cells with calcitriol, the metabolically active version of vitamin D. Calcitriol triggered a surge of calcium into the cells and the subsequent switching on of RhoARhoGTPases, which have been implicated in the cytoskeletal changes induced by vitamin D. The activated RhoA in turn switched on one of its targets, the rho-associated coiled kinase (ROCK), which then roused two other kinases. Each step in this nongenomic pathway was necessary to spur the genomic responses, the researchers showed. The team also nailed down the contribution of the vitamin D receptor (VDR). The receptor was crucial at the beginning of the pathway, where it permitted the calcium influx, and at the end, where it activated and repressed genes.

The study is the first to show that vitamin D's genomic and nongenomic effects integrate to regulate cell physiology. One question the researchers now want to pursue is whether VDR from different locationsthe nucleus, the cytosol, and possibly the cell membranehas different functions in the pathway.


'/>"/>

Contact: Rita Sullivan
212-327-8603
Rockefeller University Press
Source:Eurekalert

Related medicine news :

1. Future Looks Bright For Non-Invasive Diagnosis Of Skin Cancer; Study Shows Novel Light Device Detects Cancerous Lesions From Normal Tissue
2. Lung Cancer Genetics Different in Black Patients: Study
3. UIC joins international research effort to study autism
4. Breakthrough in cell-type analysis offers new ways to study development and disease
5. UCLA study reveals smokings effect on nurses health, death rates
6. Cardiff scientists study acute infection in end-stage kidney disease patients
7. Study Calls for Labeling of Potentially Dangerous Energy Drinks
8. Quigley Announces Completion of Phase IIb Clinical Study of QR-333 For Diabetic Peripheral Neuropathy on November 25, 2008; Collection and Evaluation of Study Data to Begin Immediately Thereafter
9. The miseries of allergies just may help prevent some cancers, study finds
10. Study Questions Screening Heart Attack Patients for Depression
11. Study: Smoking Ban Would Help Reduce Heart Attack Admissions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/21/2017)... ... April 21, 2017 , ... Contrary to popular perception, a ... declining—and at noteworthy rates. Between 2002 and 2014, Salas-Wright and his colleagues found ... in the United States. The study, Trends in Fighting and Violence Among ...
(Date:4/21/2017)... ... April 21, 2017 , ... Dudnyk has announced the launch of its ... that the full potential of specialty and orphan brands can only be achieved when ... , “The Unifying Effect is at the heart of a true partnership between our ...
(Date:4/21/2017)... ... April 21, 2017 , ... Crossover Symmetry ... O2X , an active lifestyle company that provides Human Performance Training and education ... police offers, first responders, military officers and others in service through the development ...
(Date:4/21/2017)... , ... April 21, 2017 , ... ... in the category of International Trade, the UK’s most prestigious award for business ... which represents 95% of total revenues and has grown by a total of ...
(Date:4/21/2017)... ... April 21, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House of ... in hopes of squashing a global crisis with solution to peace plan. Yisrayl says war ... because the plan is given by the Creator Himself. , Yisrayl says war drums ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... April 19, 2017 The Mobile X-Ray product segment ... healthy CAGR during the forecast period Mobile X-Ray ... global digital mobile X-Ray devices market, which is estimated to ... expanding at a CAGR of 7% over the forecast period. ... of more than US$ 100 Mn in 2017 over 2016. ...
(Date:4/19/2017)... India , April 19, 2017 ... and Application, Forecast to 2022 report has covered and analysed ... statistics and information on market size, shares and growth factors. ... major drivers, challenges and opportunities in the global market. ... Browse 152 Tables and Figures, ...
(Date:4/19/2017)... 2017  SARES•REGIS Group leased the first of ... Conejo Spectrum Business Park in Thousand ... Inc. , a biopharmaceutical company developing meaningful therapies ... have been underserved by scientific innovation, with an ... autoimmune and infectious disease. Before commencement ...
Breaking Medicine Technology: