Navigation Links
Study gives clue as to how notes are played on the genetic piano
Date:5/12/2011

SAN ANTONIO, Texas, U.S.A. (May 12, 2011) Japanese and U.S. scientists in the young field of epigenetics Thursday reported a rationale as to how specific genes are silenced and others are not. Because this effect can be reversed, it may be possible to devise therapies for cancer and other diseases using this information.

The NOVA U.S. public television program described epigenetics as "The Ghost In Your Genes." It is the study of changes in gene expression that occur without changes in DNA sequence. Like keys on a piano, DNA is the static blueprint for all the proteins that cells produce. Epigenetic information provides additional dynamic or flexible instructions as to how, where and when the blueprint will be used. "It corresponds to a pianist playing a piece of music," said Kohzoh Mitsuya, Ph.D., postdoctoral fellow in the School of Medicine at The University of Texas Health Science Center San Antonio.

Article in Science

The study by Dr. Mitsuya and colleagues is outlined in the May 13 issue of the journal Science. The team found that a small RNA pathway is required to establish an epigenetic modification called DNA methylation at a gene that codes for mammalian proteins. DNA methylation adds chemical tags called methyl groups to specific genes, usually silencing their expression.

"DNA methylation marks are reversible, so there is great interest in devising therapeutic strategies, for instance in cancer biology, to epigenetically reactivate silenced tumor-suppressor genes or inactivate specific oncogenes in human cancer cells," Dr. Mitsuya, the Science paper's third author, said. The lead author is Toshiaki Watanabe, Ph.D., of the National Institute of Genetics in Japan and Yale University.

Environment and cancer

Beyond being reversible, DNA methylation is susceptible to environmental influences. Many cancer biologists now agree that changes in DNA methylation might
'/>"/>

Contact: Will Sansom
sansom@uthscsa.edu
210-567-2579
University of Texas Health Science Center at San Antonio
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Despite Treatment, Employees with Depression Generate Higher Absentee Costs, According to Thomson Reuters Study
2. American Council on Exercise (ACE) Study Reveals Kettlebells Provide Powerful Workout in Short Amount of Time
3. TV drama can be more persuasive than news program, study finds
4. Study carried out into biological risks of eating reptiles
5. Neuroimaging study may pave way for effective Alzheimers treatments
6. Study finds racial gaps continue in heart disease awareness
7. Luth Researchs IndicatorEDG(TM) Study Finds Americans Hopes of Achieving Their Dreams Are Fading
8. First blinded study of venous insufficiency prevalence in MS shows promising results
9. Soothing infants with food focus of childhood obesity study
10. People with anxiety disorder less able to regulate response to negative emotions, study shows
11. American Heart Association Rapid Access Journal Report: Study Finds Racial Gaps Continue in Heart Disease Awareness, Low Knowledge of Heart Attack Warning Signs Among Women
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study gives clue as to how notes are played on the genetic piano
(Date:5/28/2015)... 2015 Although many people have resigned ... their slow metabolism for life, never being able to ... true. There are methods to jump start the metabolism. ... low-carbohydrate, low-fat and no-fat foods, cleverly worded to lure ... times the foods contain hidden ingredients and hidden ...
(Date:5/28/2015)... May 28, 2015 SpendWell Health, an ... it has been named a “Cool Vendor” by Gartner ... Vendors in Healthcare Payers, 2015 by Jeff Cribbs, ... report highlights innovative vendors, products and services in health ... in the health care payer market. , SpendWell’s ...
(Date:5/28/2015)... (PRWEB) May 28, 2015 The Cancer ... hands-down the most rewarding, researched and heartfelt book the ... thanked Dr. Westman for writing what should be ... Information is power and there is power in action and ... word no one wants to talk about and unfortunately many ...
(Date:5/28/2015)... The 110-mile April 24-26 Face of America ... World T.E.A.M. Sports is featured in a series of ... , Host Bob Calvert and videographers Andy and Ryan ... sponsors and staff members. The April 24 Face of ... by The American Bombshells and a keynote talk by ...
(Date:5/27/2015)... 2015 Calls Upon Individuals, Organizations and Communities ... nationwide initiative – a “Summer of Service” – seeks the ... partnerships to grow the number of individuals and organizations serving ... to Veterans by inviting the community to visit and explore ... 2015 from 1 – 3:00 p.m. in the auditorium. , ...
Breaking Medicine News(10 mins):Health News:As Part of their Comprehensive Weight Loss Program, Diet Doc Now Teaches Patients how to Identify Hidden Carbohydrates for Safe, Fast and Long Term Weight Loss Success 2Health News:As Part of their Comprehensive Weight Loss Program, Diet Doc Now Teaches Patients how to Identify Hidden Carbohydrates for Safe, Fast and Long Term Weight Loss Success 3Health News:As Part of their Comprehensive Weight Loss Program, Diet Doc Now Teaches Patients how to Identify Hidden Carbohydrates for Safe, Fast and Long Term Weight Loss Success 4Health News:SpendWell Named a “Cool Vendor” by Gartner 2Health News:SpendWell Named a “Cool Vendor” by Gartner 3Health News:SpendWell Named a “Cool Vendor” by Gartner 4Health News:Booksandauthor Cites The Cancer Solution as One of the Most Important Books to Read 2Health News:Videos Document World T.E.A.M. Sports' April 24-26 Face of America Bicycling Ride to Gettysburg 2Health News:Videos Document World T.E.A.M. Sports' April 24-26 Face of America Bicycling Ride to Gettysburg 3Health News:VA Begins “Summer of Service” to Bolster Volunteer Assistance for Veterans 2Health News:VA Begins “Summer of Service” to Bolster Volunteer Assistance for Veterans 3
... patients' family members rather than interpreters to provide language ... of Medicine, the Baltimore Examiner reports. ,For ... fellow at Johns Hopkins School of Medicine, and colleagues ... and found that 58% of physicians use bilingual staff ...
... Physicians, recommend that women ages 40 to 49 consult ... screening, the Washington Post reports. ,According to ... review from a six-member expert panel of 117 studies ... the negative consequences of mammograms. ,The panel ...
... ice caps are in terminal decline because of global warming, ... late last year revealed that the rate of melting across ... previously stable glaciers in jeopardy. ,The loss ... water supplies of millions of people within a few decades, ...
... cancer is one step closer this week with the ... new Wesley Research Institute Tissue Bank//. ,The Tissue ... to provide a widely available and diversified collection of ... the cause, progression and potential treatment for cancer and ...
... mostly older male veterans suffering from chronic obstructive pulmonary ... to lung cancer, researchers found that regular use of ... developing lung cancer. ,David H. Au, M.D., M.S., ... in Seattle, along with five associates found that among ...
... a cream containing the male sex hormone testosterone, which ... help prevent Alzheimer's, a progressive brain disorder.// ,People ... judgments, communicate and carry out daily activities. As the ... and behavior, such as anxiety, suspiciousness or agitation, as ...
Cached Medicine News:Health News:Bolivian Glacier Melts, Dangerously Fast 2Health News:Cure for Cancer One Step Closer 2Health News:High Dose Inhaled Corticosteroid Use for COPD Could Cut Risk of Lung Cancer 2
(Date:5/27/2015)... Research and Markets( http://www.researchandmarkets.com/research/ljsxt8/asia_pacific ) has announced the ... Market - Growth, Trends And Forecasts (2014 - 2019)" ... Asia Pacific market for Portable X-Ray Devices is ... 2020 X-Ray is a form of electromagnetic radiation ... especially bones. The need of point of care diagnostics has ...
(Date:5/27/2015)... 2015 Doctors from the Sheikh Zayed ... National Health System are the first in ... osteoma, a benign but painful bone tumor that commonly ... magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU) method. Two patients, ... Shah , have been treated successfully in a research ...
(Date:5/27/2015)... , May 25, 2015 Research ... of the "2015 Strategies in the Global ... This comprehensive seven-country report contains 650 ... current suppliers and potential market entrants identify and ... testing market during the next five years. ...
Breaking Medicine Technology:Asia Pacific Portable X Ray Devices Market 2015 - Trends And Forecasts to 2019 2Children's National first in US to destroy bone tumors with incisionless surgery 2Children's National first in US to destroy bone tumors with incisionless surgery 3Children's National first in US to destroy bone tumors with incisionless surgery 4Global Coagulation Testing Market Strategies 2015 2Global Coagulation Testing Market Strategies 2015 3
... Sept. 8 BHR Pharma, LLC ... 3, multi-center pivotal trial ( www.synapse-trial.com ) to evaluate ... a neuroprotective agent for treating severe traumatic brain injury (TBI) patients ... approximately 1,200 patients with severe (Glasgow Coma Scale scores of 4-8), ...
... , , University ... drive up high blood pressure, raise risk of heart attack , ... known that measures such as exercise, a healthy diet and not smoking ... Michigan Health System have determined the very air we breathe can be ...
Cached Medicine Technology:BHR Pharma Announces Phase 3 SyNAPSe Study of Progesterone as a Neuroprotective Agent for Traumatic Brain Injury 2Inhaling a Heart Attack: How Air Pollution Can Cause Heart Disease 2Inhaling a Heart Attack: How Air Pollution Can Cause Heart Disease 3
Inquire...
... is ideal for repeated pipetting ... volume FInnpipettes offer the same ... Finnpipette Digital pipettes: New, ... Soft-touch tip ejection, Safety label, ...
Pipetman F is a fixed-volume, air-displacement pipette. Thirteen robust models cover a large volume range from 2 L to 1000 L, with Gilsons legendary accuracy and precision....
... The new Finnpipette Focus from ... to combine ergonomics with uncompromising ... handle plate offers a custom ... The new shorter tip cones ...
Medicine Products: