Navigation Links
Study further expands understanding of leptin's role in brain neurocircuitry
Date:6/2/2009

ave identified two types of leptin-responsive neurons, the Agouti-related peptide (AgRP) neurons, which stimulate appetite and the pro-opiomelanocortin (POMC) neurons, which curb appetite.

"Still other studies had indicated that, by way of the ARC, leptin also had a function in both blood-sugar control and in activity levels," notes Bjorbaek. "We hypothesized that, in both cases, the POMC neurons were involved."

To test their hypothesis, the scientists studied a group of leptin-receptor-deficient laboratory mice. "The animals were severely obese and profoundly diabetic," he explains. "Using Cre-Lox technology we were able to genetically and selectively re-express leptin receptors only in the POMC neurons. When leptin receptor activity was restored to just this very small group of neurons, the mice began eating about 30 percent fewer calories and lost a modest amount of weight." And, he adds, even more dramatically, the animals' blood sugar levels returned to normal independent of any change in weight or eating habits, and their activity levels spontaneously doubled.

While more research is needed to explain the mechanisms at play, it may be that the POMC neurons reduce blood glucose by regulating key organs such as the liver or muscle tissue. "Normally, the liver is critical for increasing glucose production between meals in order to provide fuel for the brain, while skeletal muscle is important for the removal of glucose from the blood immediately after a meal," he notes. In this case, however, the POMC neurons may be decreasing glucose release into the blood by the liver and/or increasing glucose uptake from the blood into muscle.

"The fact that normal glucose levels were restored independent of food or weight changes is important because it suggests that it is possible to normalize blood glucose even without weight loss," explains Bjorbaek. "Furthermore, our finding that the mice had greatly increased activity levels despite st
'/>"/>

Contact: Bonnie Prescott
bprescot@bidmc.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. NASA Selects Four Proposals to Study Space Radiation Risks
2. Study Results Show CAQH CORE Certification Dramatically Cuts Administrative Costs, Accelerates I.T. Adoption by Providers and Health Plans
3. Study: Benefit to women not enough to sway men to get HPV vaccine
4. New study shows people with mental health problems receive inadequate medical care
5. Hyperion Therapeutics Announces Results of Phase I Study in Patients With Liver Cirrhosis
6. Ground-breaking study to cap the growing trend of type 2 diabetes in overweight adolescents
7. Study to Investigate AHCC and the Swine Flu Virus
8. New Study Documents High Prevalence of Serious Mental Illnesses Among Nations Jail Populations
9. New Market Research Study Shows Lung Cancer Treatments Differ Significantly by Both Age and Geography
10. Study shows gay couples want legal rights, regardless of marriage
11. Hopkins study: When adult patients have anxiety disorder, their children need help too
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... ... July 31, 2015 , ... ... logic applies when purchasing disability insurance, where price is an important factor to ... with a leading insurance carrier, offers the Preferred Producer Multi-Life Discount program, where ...
(Date:7/31/2015)... (PRWEB) , ... July 31, 2015 , ... ... apnea (OSA) and the growing number of individuals who remain undiagnosed, treatment options ... continue to shy away from traditional CPAP therapy due to its overall lack ...
(Date:7/30/2015)... ... July 30, 2015 , ... Dale Sky Jones, Executive Chancellor ... speak at the International Cannabis Professionals Expo held at the Caribe Royal All Suites ... International Cannabis Professionals Expo is the largest medical cannabis expo in the country ...
(Date:7/30/2015)... Providenciales, Turks & Caicos Islands, BWI (PRWEB) , ... July 31, 2015 , ... The ... special offer for fall, 2015. Guests who stay at the Venetian will save 40% ... , The fall months are always quiet in the Turks & Caicos, providing a ...
(Date:7/30/2015)... ... , ... Committed to helping the next generation succeed - Mercy College is ... the College’s “My Brother’s Keeper Scholarship.” The President’s signature initiative issues a call to ... support they need to think more broadly about their future. Building on what works ...
Breaking Medicine News(10 mins):Health News:Secura Consultants Gives Advisers Competitive New Edge with Multi-Life Discount Program 2Health News:Oravan Sleep Apnea Device Gains Traction in Sleep Industry 2Health News:Finally…First Ever Professional Training Event for Doctors and Nurses Wanting to Offer Medical Marijuana Recommendations to Patients 2Health News:Finally…First Ever Professional Training Event for Doctors and Nurses Wanting to Offer Medical Marijuana Recommendations to Patients 3Health News:Finally…First Ever Professional Training Event for Doctors and Nurses Wanting to Offer Medical Marijuana Recommendations to Patients 4Health News:Finally…First Ever Professional Training Event for Doctors and Nurses Wanting to Offer Medical Marijuana Recommendations to Patients 5Health News:The Venetian on Grace Bay in Turks & Caicos Islands Offers 40% Savings This Fall. 2Health News:Mercy College a “My Brother’s Keeper” Community 2Health News:Mercy College a “My Brother’s Keeper” Community 3
... Steven Reinberg HealthDay Reporter , WEDNESDAY, Oct. 5 (HealthDay ... introduced the world to personal computers, then the iPod, the iPhone ... cancer. He was 56. "Apple has lost ... amazing human being," the company said in a statement it posted ...
... of strategies released today by the Commonwealth Fund Commission ... how the U.S. health care system serves vulnerable populationsthose ... of racial and ethnic minority groups. According to ... Achieve High Performance Health Care for Vulnerable Populations, closing ...
... AMHERST, Mass. -- New research based on post-hospital arrival ... adjusting for differences in injury severity, gun use, and ... assault, African-Americans have a significantly higher overall post-scene of ... by Anthony R. Harris, emeritus professor of sociology at ...
... 12 or older are estimated to have driven under the ... a 2009 National Survey on Drug Use and Health. While ... its role in causing crashes has remained in question. To ... of a car accident, researchers at Columbia University did a ...
... and run and how their knees look in an MRI ... decades in advance whether they will develop osteoarthritis, the common ... the time they reach the age of 70. Doctors ... scan and tell you definitively whether or not they will ...
... (HealthDay News) -- Technology that directly oxygenates the blood reduced ... by the H1N1 flu virus, a new British study shows. ... they noted that debate continues about the use of the ... called extracorporeal membrane oxygenation, which oxygenates the blood. It,s used ...
Cached Medicine News:Health News:Steve Jobs, Visionary Leader of Apple Inc., Dies at 56 2Health News:Steve Jobs, Visionary Leader of Apple Inc., Dies at 56 3Health News:Strategy for improving health care for uninsured, low-income, and minorities in the US 2Health News:Strategy for improving health care for uninsured, low-income, and minorities in the US 3Health News:Strategy for improving health care for uninsured, low-income, and minorities in the US 4Health News:Strategy for improving health care for uninsured, low-income, and minorities in the US 5Health News:Researchers find race disparity in post-hospital arrival homicide deaths at trauma centers 2Health News:Marijuana use may double the risk of accidents for drivers 2Health News:$6.3 million center at UCSF and UC Davis seeks ways to diagnose and prevent osteoarthritis 2Health News:$6.3 million center at UCSF and UC Davis seeks ways to diagnose and prevent osteoarthritis 3Health News:Oxygenating Blood of Hospitalized H1N1 Flu Patients Saved Lives: Study 2
(Date:7/30/2015)... 30, 2015  ResMed (NYSE: RMD ... definitive agreement to acquire Curative Medical, a ... sleep-disordered breathing medical devices and accessories. ... with ResMed,s global leadership in sleep and respiratory medicine, ... China suffering from sleep-disordered breathing ...
(Date:7/30/2015)... Calif. , July 30, 2015  EP ... /Alcon executives have recently contacted the Company about ... begin as early as Monday, August 3, 2015.  ... quoted as saying that the coming electronic contact ... of dollars over the next several years.  Novartis ...
(Date:7/30/2015)...  Amgen (NASDAQ: AMGN ) today announced ... Key results include: , Total revenues increased ... to $5,370 million, with 6 percent product sales ... Prolia ® (denosumab), Sensipar ® (cinacalcet), ... (denosumab). Unfavorable changes in foreign exchange rates impacted ...
Breaking Medicine Technology:ResMed Invests in High-Growth Chinese Sleep and Respiratory Care Market with Curative Medical 2ResMed Invests in High-Growth Chinese Sleep and Respiratory Care Market with Curative Medical 3Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 2Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 3Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 4Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 5Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 6Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 7Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 8Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 9Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 10Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 11Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 12Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 13Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 14Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 15Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 16Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 17Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 18Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 19Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 20Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 21Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 22Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 23
... LIONVILLE, Pa., Dec. 16, 2010 West Pharmaceutical Services, Inc. (NYSE: ... has approved payment of the first-quarter 2011 cash dividend of $0.17 ... to shareholders of record on January 19, 2011. ... of components and systems for injectable drug delivery, including stoppers and ...
... (Nasdaq: HSKA, "Heska" or the "Company"), announced today that ... Forever, has been awarded $25,000 as the grand prize ... (Logo: http://photos.prnewswire.com/prnh/20000622/HESKALOGO) Helping low-income ... their pets for as long as possible, Pets Forever ...
Cached Medicine Technology:Heska Corporation Awards $25,000 Grand Prize to Pets Forever 2
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: