Navigation Links
Study first to show that RNA interference can facilitate vaccine development
Date:12/10/2008

revented detectable disease in the mice.

Tripp pointed out that RSV replication was reduced in a dose-dependent manner, meaning that the viral load decreased in proportion to the amount of drug administered. He said it's possible to halt viral replication entirely with higher doses of the drug, but that his goal was to expose the immune system to enough of the virus so that it could mount a strong response upon future exposure.

In the next phase of the study, the researchers took mice that three weeks earlier were exposed to RSV after being prophylactically treated with either the drug or the controls and challenged them with the virus for a second time. The researchers found that levels of specific cells associated with the memory immune response were substantially increased in the experimental group versus the control groups, while the mice treated with the siRNA drug had virus concentrations that were more than 80 percent less than the control groups and recovered an average of two days faster.

"This is the first study of its kind to show the utility of using any siRNA to improve the immune system's memory response to an infectious agent," Tripp said. "We were able to reduce virus replication enough to prevent the development of disease but still induce immunity later on."

Between 75,000 to 125,000 children under age one are hospitalized with complications of RSV annually, according to the Centers for Disease Control and Prevention. Tripp notes that there is currently no effective vaccine for the virus. Unlike most viruses, the exact same strain of RSV can infect the same person repeatedly. Scientists are just now beginning to understand the many ways in which RSV evades the memory immune response, but Tripp's finding reveals that keeping RSV replication and protein expression at a low level prevents the virus from eluding the immune system.

Tripp said preliminary data also suggest siRNA drugs are likely to behave as e
'/>"/>

Contact: Sam Fahmy
sfahmy@uga.edu
706-542-5361
University of Georgia
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Penn study finds pro-death proteins required to regulate healthy immune function
2. New study shows promise in reducing surgical risks associated with surgical bleeding
3. Study, meta-analysis examine factors associated with death from heatstroke
4. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
5. Study says COPD testing is not measuring up
6. Preclinical study suggests organ-transplant drug may aid in lupus fight
7. Ability to cope with stress can increase good cholesterol in older white men, study finds
8. High alcohol consumption increases stroke risk, Tulane study says
9. Mailman School of Public Health study examines link between racial discrimination and substance use
10. Pitt study finds inequality in tobacco advertising
11. Stanford study highlights cost-effective method of lowering heart disease risks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/6/2015)... (PRWEB) May 06, 2015 On April ... on Plastic Surgery ,” compiled quotes about cosmetic ... Jennifer Aniston, pop singer Iggy Azalea, and Gwyneth Paltrow. ... sentiments about having plastic surgery themselves; only ... society and its expectations of youth and beauty. (see: ...
(Date:5/6/2015)... 06, 2015 Qushanna Doby (20) was arrested ... drug treatment center in Florida while under the influence of ... New surveillance tapes released by CBS4’s Peter D’Oench records Doby ... Doby’s child is around one year old. The drug treatment ... outside was not named. The residents polled by CBS Miami ...
(Date:5/6/2015)... Orlando, FL- May 05, 2014 (PRWEB) May 06, ... and Grant Lock accepted, on behalf of MEBC, ... retail organizations from JDA Software during FOCUS 2015, ... of attendees across the manufacturing, retail and wholesale ... consistently ensuring that their clients are receiving services ...
(Date:5/6/2015)... MD (PRWEB) May 06, 2015 The Canton ... Baltimore Ravens for the 6th annual charity softball game. ... at M & T Bank Stadium. Past years guests include ... others. Tickets are still on sale if you ... advocating for local non-profit organizations, such as SOAR Baltimore ...
(Date:5/6/2015)... Baptist Medical Center Jacksonville and ... north Florida and southeast Georgia region offering MAKOplasty® ... in total hip replacement surgery performed using the ... that enables the accurate alignment and positioning of ... MAKOplasty® partial knee resurfacing using the RIO system ...
Breaking Medicine News(10 mins):Health News:Plastic Surgery: Sixteen Celebrities Offer their Opinion about Going Under the Knife 2Health News:Flakka Induced Mother Abandons Baby, found by Florida Drug Treatment Center; New Video Released 2Health News:MEBC Receives Award for Consulting Excellence in Retail 2Health News:The Canton Group Sponsors Ravens Charity Softball Event 2Health News:The Canton Group Sponsors Ravens Charity Softball Event 3Health News:Baptist Health and Jacksonville Orthopaedic Institute Offering MAKOplasty® Total Hip Replacement 2Health News:Baptist Health and Jacksonville Orthopaedic Institute Offering MAKOplasty® Total Hip Replacement 3Health News:Baptist Health and Jacksonville Orthopaedic Institute Offering MAKOplasty® Total Hip Replacement 4
... link between pregnancy, migraine and stroke, US researchers said. ... ,In fact, Cheryl Bushnell, assistant professor of ... in Durham, explained that pregnant women who suffered migraine ... pregnant women who did not suffer migraine. ...
... Department of Biotechnology (DBT), Ministry of Science & ... Vaccine Initiative signed an agreement today to ... the design of candidate vaccines to elicit neutralizing ... Programme, co-sponsored and co-funded by IAVI and the ...
... made by Novartis AG and Fosamax manufactured by Merck and Co ... of women users. Both are known bone-building drugs. ,The ... given as an annual shot. But there was a hint of ... pill, Fosamax by Merck & Co. They are all at risk ...
... children in Australian are succumbing to infections. And that in ... parents fall back on the day care centres. ... West Australian children found infectious diseases were the most common ... ,Researchers at the Telethon Institute for Child Health Research found ...
... is no hard and fast rule as to how a mother ... than glad to endorse that view as standard positions like ... feelings to override. , Take the case of Nicola ... her daughter Deborah was born. ,As manager of a ...
... feed is causing concern among the people. The consumption of chicken ... FDA is quick to play down the fear saying that it ... to light after some 38 chicken farms in Indiana was investigated ... chicken for human consumption with the contaminated feed. Until the investigation ...
Cached Medicine News:Health News:DBT And IAVI Forge Partnership To Develop Next Generation Vaccine Candidates 2Health News:DBT And IAVI Forge Partnership To Develop Next Generation Vaccine Candidates 3Health News:Anti-osteoporosis Drugs Could Result in Irregular Heart Rhythm, New Study 2Health News:New Research Promises To Take The Pain Off Breast Feeding 2Health News:New Research Promises To Take The Pain Off Breast Feeding 3Health News:Tainted Pet Food a Health Risk for Human? 2
(Date:5/6/2015)... , May 6, 2015 In ... malaria and tuberculosis combined[1]. Approximately 40 percent of cancer cases ... the right treatment[3]. Together with Elekta, ministries of health in ... their radiation therapy infrastructures and save lives. More ... from radiation therapy[4] during the course of their disease, either ...
(Date:5/6/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/4fgrnh/asiapacific ) ... Internal Trauma Fixation Devices Market by Type & ... report to their offering. The ... to grow at a CAGR of 6.7% from ... rising incidences of road accidents, increasing aging population, ...
(Date:5/6/2015)... GenSpera, Inc. (OTCQB: GNSZ) announced today that the patent ... process in 17 countries and regions, including Europe ... China , Brazil and ... patent application will extend the exclusivity period for GenSpera,s core ... drug candidate, mipsagargin, until 2033. This recent patent ...
Breaking Medicine Technology:Elekta to bring cancer treatment to millions in Africa 2Elekta to bring cancer treatment to millions in Africa 3Elekta to bring cancer treatment to millions in Africa 4Asia-Pacific Internal Trauma Fixation Devices (Internal Trauma Fixation Plates, Screws, Rod Wires & Pins, Fusion Nails) Market 2015 2GenSpera Enters National Phase with Patent Application for Injectable Prodrug Formulations 2
... counterparts when it comes to the consumption of mental health ... as compared to 15 percent of men.  These are findings ... MHS ) that were presented Saturday at the 2012 Women,s ... The study reviewed the pharmacy claims of more ...
... 19, 2012 Ventana Medical Systems, Inc. ( ... is now introducing a novel platform for special ...  Answering customers, challenges with their current process, the ... walk-away automation, baking through staining including deparaffinization, random ...
Cached Medicine Technology:The Mental Health Gender Gap: Women Far Exceed Men in their Use of Psychotropic Medications as Utilization Increases Among Both Sexes 2The Mental Health Gender Gap: Women Far Exceed Men in their Use of Psychotropic Medications as Utilization Increases Among Both Sexes 3Ventana Introduces the BenchMark Special Stains Platform 2Ventana Introduces the BenchMark Special Stains Platform 3
The MC-3 allows for simultaneous use of two lamps, with an additional built-in spare....
Xenon technology achieves a higher efficiency than halogen light sources. Consequently they provide more light....
Delivers one primary lamp and one backup lamp. The port accepts ACMI fiberoptic cables....
A three lamp light source maximizes use by allowing two surgeons to work simultaneously from it, while the third lamp is reserved for backup....
Medicine Products: