Navigation Links
Study finds women with triple negative breast cancer and BRCA mutations have lower risk of recurrence
Date:9/29/2010

HOUSTON - Patients with triple negative breast cancer that also have mutations in the BRCA gene appear to have a lower risk of recurrence, compared to those with the same disease without the deleterious genetic mutation, according to researchers at The University of Texas MD Anderson Cancer Center.

The findings may offer a direction for study of personalized therapy in this select group of triple negative breast cancer patients, as well as highlight the unique need for genetic testing in a patient population. Ana M. Gonzalez-Angulo, M.D., associate professor in MD Anderson's Departments of Breast Medical Oncology and Systems Biology presented the findings in advance of the 2010 Breast Cancer Symposium.

"There is data on the number of breast cancer patients with BRCA mutations, as well as those that have triple negative disease. However, there is no understanding of the incidence of BRCA1 and 2 mutations in unselected patients with triple negative breast cancer," said Gonzalez-Angulo, the study's first and corresponding author. "Now, there are new drugs that appear to be more effective in treating triple negative breast cancer and BRCA status may be an important way of selecting patients that may respond to these therapies."

Triple negative disease - breast cancer that is estrogen, progesterone and HER2-neu receptor negative - accounts for about 15 percent of all breast cancers. Currently, it's an area of much research focus in the breast cancer community because: it lacks effective targets effective for anti-cancer therapies; chemotherapy is only effective in about 40 percent of patients; and in those that do relapse, the disease is highly resistant and patients die quickly.

PARP inhibitors, a class of drugs of growing interest in cancer research, have shown promise in both patients with BRCA and triple negative disease. PARPs appear to be more effective in patients with BRCA mutations, as both PARP enzymes and proteins produced by the BRCA genes are involved in the repair of DNA. Therefore, the MD Anderson finding may provide an early idea of how to select those triple negative breast cancer patients that may respond best to therapy.

For this study, part of Gonzalez-Angulo's ongoing laboratory project, Molecular Characterization of Triple Negative Breast Cancer, the researchers sent both tumor and normal tissue of 77 women with triple negative disease to Myriad Genetics Inc. to identify germline (inherited) and somatic (in tumor only) BRCA mutations. Of those 77 patients, 15 (19.5 percent), were found to have mutations (14 germline, one somatic) -12 (15.6 percent) with BRCA1 and three (3.9 percent) with BRCA2.

The triple negative breast cancer patients were treated at MD Anderson between 1987 and 2006, and all but one received the same adjuvant chemotherapy regimen. The median follow-up was 43 months. The five-year relapse-free and five-year overall survival of the patients with either BRCA mutation, was 86,2 percent, and 73.3 percent, respectively, compared to 51.7 percent and 52.8 percent, respectively, in patients lacking mutations.

The researchers were surprised by the findings, however, Gonzalez-Angulo notes that prior studies conducted were case-controlled looking at BRCA mutations carriers with all types of breast cancer. The MD Anderson study is the first to look exclusively at women with triple negative breast cancer, an unselected population.

Also surprising, the incidence of BRCA mutations in the triple negative breast cancer population was higher than expected, said Gonazlez-Angulo.

"It was interesting to find that a good portion of these women were not sent to genetic counseling - some didn't meet the criteria to be sent for testing, however they still had BRCA mutations," said Gonazlez-Angulo. "Perhaps we need to lower our threshold for patients with triple negative breast cancer for genetic counseling and to assess for mutation status - especially those under age 50 - despite not having the significant family history as others."

As a follow up, Gonzalez-Angulo plans to continue her ongoing laboratory research, with signaling pathways, RNA, DNA, and other mutations of the disease.


'/>"/>

Contact: Laura Sussman
lsussman@mdanderson.org
713-745-2457
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

Related medicine news :

1. UT MD Anderson study finds women treated for breast cancer while pregnant have improved survival
2. Anti-Inflammatory Helps Treat Bacterial Meningitis: Study
3. UTHealth researcher receives grant for Alzheimers study
4. Dirty hands, dirty mouths: U-M study finds a need to clean the body part that lies
5. Study Finds Home Dialysis as Good as Hemodialysis at Centers
6. C-Reactive Protein Levels Vary By Race: Study
7. TGen/Mayo Clinic/Arizona Cancer Center study finds gene associated with aggressive skin cancer
8. Pet allergies worsen hay fever symptoms, Queens study finds
9. Wider statin use could be cost-effective preventive measure, Stanford study finds
10. New Tool Helps Predict Stroke Patients Risk of Death in Hospital: Study
11. VCU study: Researchers discover a drug combination that shrinks tumors in vivo
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study finds women with triple negative breast cancer and BRCA mutations have lower risk of recurrence
(Date:1/24/2017)... (PRWEB) , ... January 24, 2017 , ... The ... MSC Cruises as part of the line’s 4th Annual MSC True Partnerships’ Awards. ... performing North American travel partners for the year based on overall business growth in ...
(Date:1/24/2017)... (PRWEB) , ... January 24, 2017 , ... ... advance to the semi-final round of the 2017 Cupid's Cup Entrepreneurship Competition. Chaired ... its 12th year in 2017. The entrepreneurs will showcase their businesses on February ...
(Date:1/24/2017)... ... January 24, 2017 , ... West’s Health Advocate Solutions, ... Series of webinars will start January 31 with a session about understanding healthcare ... health and benefits topics, including employee engagement, pricing transparency, population health and wellness, ...
(Date:1/24/2017)... ... ... His message has been heard by more than 100,000 students and adults ... Joel Feldman, has reached his biggest national audience yet: the three million daily readers ... in circulation in the country, and he hopes it will help spread his message ...
(Date:1/24/2017)... Santa Margarita, CA (PRWEB) , ... January 24, 2017 , ... ... advancement platform for 21st century leadership, has named Hector M. Chavez, Manager, Employee & ... and diabetes treatment center - as its Hispanic Leader of the Month. City of ...
Breaking Medicine News(10 mins):
(Date:1/24/2017)... -- Trifecta Clinical , a leading global provider ... Ward to Vice President of Commercial Operations.  Rick ... the promotion of Ericka Atkinson to Vice ... joins Trifecta from Greenphire where he was Vice President ... positions within the healthcare industry throughout his career.  "Rick ...
(Date:1/24/2017)... Research and Markets has announced the addition of the "Implantable ... to 2025" report to their offering. ... The Global Implantable Medical Devices Market ... the next decade to reach approximately $54.28 billion by 2025 ... include 3D medical printing is expected to develop and find in ...
(Date:1/24/2017)... , and GAITHERSBURG, Md. , Jan. 24, ... ), a leader in the engineering and industrialization of biology ... planet, today announced that it has entered into a definitive ... GNVC ), a clinical-stage company and pioneer in the development ... to integrate and expand upon GenVec,s expertise in adenoviral vectors ...
Breaking Medicine Technology: