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Study finds why some women are sub-fertile with a poor response to ovarian stimulating hormones
Date:6/29/2010

show the opposite: that lower FSH may be more beneficial."

Future research will examine the FSHR signalling mechanisms within the cell and investigate how newly developed drugs might bypass the problems created by the genetic abnormality. "In the future, this could lead to personalised treatments for a sub-group of patients," said Dr Lalioti.

It is not known how many women have this particular genetic variation. Dr Lalioti found it in two out of five women that she tested. "These patients are hard to recruit because most patients with a low response to FSH do not complete the IVF cycle for financial reasons," she said. "We need to recruit more patients to discover how common it is." She and her colleagues will need a year to recruit and test more women, to set up collaborations with more fertility centres and to start to test new drugs that could promote oocyte production more effectively in these women.


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Contact: Emma Mason
wordmason@mac.com
European Society of Human Reproduction and Embryology
Source:Eurekalert

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