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Study finds vaccine extends recurrent GBM survival rates by 2 to 3 times
Date:6/3/2011

nitiated within 5 weeks post-surgery and consisted of 25 g HSPPC-96, given ID weekly x 4, followed by bi-weekly injections for up to 52 weeks. Results: A total of 33 patients at first recurrence (M:F = 25:8) with a median KPS of 80 were entered. A median of 6 injections (range: 1-15) were administered to the ITT population, with a requisite of 4 vaccinations for the evaluable population. The vaccine was well tolerated with no attributed serious adverse events and no related grade 3 or 4 toxicities. Injection site reaction was seen in 12 patients and fatigue was reported in 9 patients. As of Jan. 2011, the median survival (KM estimates) is 324 days for ITT population (37-877) and 333 days for evaluable population (99-877). 11 patients are still alive and being followed, including 4 beyond one year (374d, 419d, 578d, and 877 days, respectively). All patients with immunological endpoints tested to date exhibited a significant innate immune response and all patients demonstrated CD8 T cell IFN gamma production upon restimulation with autologous gp-96; following vaccine administration. Conclusions: HSPPC-96 evokes a specific and innate immune response in patients with recurrent glioma and survival data available to date indicates HSPPC-96 vaccine provides a possible clinical benefit with a favorable safety profile. Collectively these results provide the impetus for Phase 3 testing against currently approved therapies for patients with recurrent glioblastoma.


Cynthia Owusu, MD, MS
Title: The trajectory of physical functioning during breast cancer treatment of older women.

Saturday June 4, 2:00 PM to 6:00 PM

Abstract (http://abstract.asco.org/AbstView_102_81152.html): Background: We sought to characterize the trajectory of physical functioning during the first 12 months following initial breast cancer diagnosis in older women with stage I-
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Contact: Alicia Reale
alicia.reale@uhhospitals.org
216-533-0685
University Hospitals Case Medical Center
Source:Eurekalert

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