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Study finds vaccine extends recurrent GBM survival rates by 2 to 3 times
Date:6/3/2011

njections, followed by bi-weekly injections for up to 52 weeks.

"The vaccine is made from a patient's own cells, so it takes into account what is unique about the patient's particular tumorit's the ultimate in 'personalized medicine'," said Dr. Sloan who also is the Peter D. Cristal Chair in Neurosurgery and an Associate Professor of Neurological Surgery at Case Western Reserve University School of Medicine.

In addition to this promising research, UH Case Medical Center's Seidman Cancer Center physician scientists presented a variety of oral and poster presentations at ASCO. Notably, Cynthia Owusu, MD, breast oncologist, is presenting two important abstracts related to the treatment of older women with breast cancer. Importantly, the first study concludes that one in four women, after 6 months, and one in three, after 12 months, display plummeting physical function which shows a clear need to remedy treatment options to help preserve activity of breast cancer patients later in life. UH Case Medical Center abstracts are highlighted below:

Title: Autologous heat shock protein vaccine (HSPPC-96) for patients with recurrent glioblastoma (GBM): Results of a phase II multicenter clinical trial with immunological assessments.

Monday June 6, 8:00 AM to 12:00 PM

Abstract (http://abstract.asco.org/AbstView_102_85010.html) Background: HSPPC-96 is derived from a patient's individual tumor and contains glycoprotein-96 (gp96) polypeptide associated with cancer-specific antigenic peptides. Methods: This ongoing single-arm multicenter Phase 2 trial is designed to evaluate overall survival (primary objective) and immunologic response (secondary objective) with HSPPC-96 in patients with first or subsequent recurrence of GBM. Prior treatment with radiotherapy and temozolomide was required. All patients underwent a >90% resection of the recurrence. Vaccine therapy was to be i
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Contact: Alicia Reale
alicia.reale@uhhospitals.org
216-533-0685
University Hospitals Case Medical Center
Source:Eurekalert

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