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Study finds vaccine extends recurrent GBM survival rates by 2 to 3 times
Date:6/3/2011

g/m2) 3x weekly during 5 weeks of cisplatin (40 mg/m2, 70 mg maximum) chemoradiation. Brachytherapy followed. Toxicity was monitored by common terminology criteria for adverse events v3.0. Response was assessed by exam and 3-month posttherapy positron emission tomography (PET/CT). Institutional review board approval was provided for conduct of research. Results: 14 patients tolerated 206 (98%) of 210 planned 3-AP infusions. Four patients experienced reversible 3-AP-related grade 3 leukopenia or thrombocytopenia. Two patients had reversible, possibly 3-AP-related, grade 3 hypokalemia and hyponatremia. One patient with pre-existing portal hypertension had a less than 30-day post-chemoradiation grade 4 hemorrhage secondary to an iatrogenic Mallory-Weiss tear of gastric varices, occurring before brachytherapy and resulting in death. 13 (93%) of 14 patients achieved durable complete clinical responses (median follow-up 9 months, range 3-18 months). 10 (91%) of 11 patients had 3-month PET/CT scans that recorded metabolic activity in the cervix or vagina equal or less than that of the cardiac blood pool, suggesting complete metabolic responses. Conclusions: 3-AP given 3x weekly co-administered with cisplatin chemoradiation is well tolerated and associated with a high clinical and metabolic response. Further accrual is on-going (Grant: Case Western Reserve University 5U01 CA062502).


Sanford D. Markowitz, MD, PhD

Dr. Markowitz will be part of a virtual meeting (http://www.asco.org/ASCOv2/MultiMedia/Virtual+Meeting?&vmview=vm_session_presentations_view&confID=102&sessionID=3973) discussing the topic of "Biomarkers for the Early Detection of Colon Cancer," amongst other speakers within the larger topic of, "An Update on Biomarkers for the Early Detection of Cancer, Prediction of Prognosis, and as Surrogate Endpoin
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Contact: Alicia Reale
alicia.reale@uhhospitals.org
216-533-0685
University Hospitals Case Medical Center
Source:Eurekalert

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