Navigation Links
Study finds vaccine extends recurrent GBM survival rates by 2 to 3 times
Date:6/3/2011

In data presented at The American Society of Clinical Oncology (ASCO) Annual Meeting, cancer researchers found that the brain tumor vaccine HSPPC-96 for treating recurrent gliobastoma (GBM) has a favorable safety profile and extends survival by two to three times more than the current median survival rate. Patients in the study, conducted at University Hospitals Case Medical Center, University of California, San Francisco and Columbia University, were found to have a median survival of 11 months compared to current three to five month survival.

"The findings are very favorable for patients with this deadly form of brain cancer," said Andrew Sloan, MD, one of the authors of the study presented at ASCO and Director of the Brain Tumor and Neuro-Oncology Center at University Hospitals Case Medical Center. "The vaccine is one of the few immune therapies designed specifically for patients who are not newly diagnosed, and these encouraging results make this a promising therapy for a more extensive Phase 3 trial."

HSPPC-96 isolates the heat shock protein, which is part of the immune system. The protein from the patient's tumor is then reinjected into the skin with an adjuvant, or an agent added to a drug to increase its effect.

The vaccine was developed by Andrew Parsa, MD, PhD, principal investigator of the Brain Tumor Research Center at the University of California, San Francisco. He is collaborating with the Lexington, Massachusetts biotech company called Agenus. Columbia University also is part of the ongoing Phase 2 study designed to evaluate overall survival and immunologic response with HSPPC-96 in patients with first or subsequent recurrence of GBM.

All patients underwent surgery prior to vaccine therapy. However, since the vaccine is made from the patient's own tumor, the surgery had to be performed at one of the participating sites. The vaccine therapy begins within 5 weeks after surgery and consists of four weekly i
'/>"/>

Contact: Alicia Reale
alicia.reale@uhhospitals.org
216-533-0685
University Hospitals Case Medical Center
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8 9 10 11 12

Related medicine news :

1. BUSM study finds older men more likely to lose the ability to orgasm due to gabapentin
2. Obesity Greater Risk for Fatty Liver Than Alcohol, Study Finds
3. Safer sex: Study examines sexual communication in transgender community
4. High-Risk Surgeries Getting Safer: Study
5. Study: Children of divorce lag behind peers in math and social skills
6. New grant to study how pediatric brain tumor, ependymoma, develops
7. USC study locates the source of key brain function
8. Penn study identifies genes that may help predict response to BRAF inhibitors for advanced melanoma
9. Children With ADHD More Prone to Substance Abuse: Study
10. Study finds fire stations contaminated with MRSA
11. New study looks at disconnect between medical and lay expertise
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... 2014 Following the death of an 18-year-old ... FDA issued a warning on powdered caffeine products. ... substance that is readily available to consumers, despite the fact ... senior Logan Stiner died from an overdose of caffeine powder. ... the FDA to issue a safety advisory for caffeine powders. ...
(Date:8/28/2014)... 28, 2014 Catalent Pharma Solutions, ... and development solutions for drugs, biologics and consumer ... Director Clinical Supply Services, and Chris Greco, Manager, ... Sourcing Strategies for Active Control Clinical Trials” at ... takes place on the 9th – 10th September, ...
(Date:8/28/2014)... 2014) A subset of patients with stage III ... irinotecan-based therapy, according to a new study in ... of the American Gastroenterological Association. , When added to ... adjuvant irinotecan therapy improved overall survival rates for patients ... seen in about 10 to 20 percent of colorectal ...
(Date:8/28/2014)... scientists are working out how to safely increase the ... offering improved local control and survival. , Standard treatment ... combination of radiotherapy and chemotherapy. Traditionally this is planned ... not always be enough to stop tumour growth. , ... cancerous tissue varies between patients and depends on the ...
(Date:8/28/2014)... (PRWEB) August 28, 2014 AmeriPride Services, ... America, today announced the launch of its new Customer ... AmeriPride even easier and more convenient for customers. The ... online and better communicate with the company. , Features ... Access, download and pay bills ...
Breaking Medicine News(10 mins):Health News:FDA Issues Safety Advisory for Caffeine Powders 2Health News:Critical Path Sourcing Strategies for Global Clinical Trials Presented by Catalent Experts at US Clinical Trials Supply Conference 2Health News:Drug shows promise for subset of stage III colon cancer patients 2Health News:Research demonstrates potential method to better control lung cancer using radiotherapy 2Health News:AmeriPride Services Launches New Customer Portal 2Health News:AmeriPride Services Launches New Customer Portal 3
... researchers say , SUNDAY, Nov. 18 (HealthDay News) -- ... suggests. , A U.S. team found that talking to ... and test scores. , They found that "socializing was ... exercise in boosting memory and intellectual performance," lead author ...
... costs and prepare ... covers of hospital costs and, efficiencies using more refined performance metrics ... ... A new benchmarking study was,launched today to measure the cost and efficiencies of ...
... it from spreading, expert says , , SATURDAY, Nov. 17 (HealthDay News) ... hit by the flu bug this year, but some simple precautions ... said. , The flu shot is the most effective method of ... officer at Brigham and Women,s Hospital in Boston. It,s important to ...
... Nancy Pelosi,will join Congressmen Ciro D. Rodriguez, Charlie ... the State Children,s Health,Insurance Program (SCHIP) bill that ... WHO: Speaker Nancy Pelosi Congressman Ciro D. ... Congressman Henry Cuellar (TX-28), WHAT: Rally for ...
... Nov. 16 Angel Flight West,(AFW) awarded The Distinguished ... Dan Telfair at AFW,s 24th Anniversary Awards and on ... awards event. Telfair,completed 56 missions over the past year. ... non-emergency health care problems require that they travel,to and ...
... Nov. 16 Nothing says,"Thanksgiving" like football, family and ... But no matter what,s included in a,Thanksgiving spread, one ... the American Society for Surgery of the Hand cautions,carvers ... not their own hands., Every year during Thanksgiving, ...
Cached Medicine News:Health News:Talking With Others May Make You Smarter 2Health News:Global Health Support Service Benchmark Study to Combat Growing Healthcare Costs and Prepare for Likely Health Care Reforms 2Health News:Angel Flight West Recognizes New Mexico Pilots and Receives Grant to Improve Access to Health Care 2Health News:Holiday Hand Safety 101: Hand Surgeons Offer Tips for a Safe Carving Season 2
(Date:8/28/2014)... Aug. 28, 2014  A decline in revenues ... are adding pressure to pharmaceutical, biotechnology and medical ... continue to shrink and approval processes and postapproval ... companies to look for additional support and expertise ... keeping approved products on the market.  ...
(Date:8/28/2014)... VIEJO , Californie, 28 août ... a annoncé aujourd,hui le début des ... d,une étude  d,exemption des dispositifs expérimentaux ... destinée à évaluer l,innocuité et l,efficacité ... (« WEB »). Le docteur Adam Arthur ...
(Date:8/28/2014)... , Aug. 28, 2014  Celsion Corporation (NASDAQ: ... company, today announced that Michael H. Tardugno , ... at the Rodman & Renshaw 16th Annual Healthcare Conference ... a.m. Eastern Time. The conference is being held at ... A copy of the presentation will be available on ...
Breaking Medicine Technology:4 Key Factors to Consider When Choosing an Effective Regulatory Outsourcing Partner 24 Key Factors to Consider When Choosing an Effective Regulatory Outsourcing Partner 34 Key Factors to Consider When Choosing an Effective Regulatory Outsourcing Partner 4Sequent Medical annonce le démarrage d'une étude IDE pour le système WEB d'embolisation des anévrismes 2Sequent Medical annonce le démarrage d'une étude IDE pour le système WEB d'embolisation des anévrismes 3Sequent Medical annonce le démarrage d'une étude IDE pour le système WEB d'embolisation des anévrismes 4Celsion to Present at the Rodman & Renshaw 16th Annual Healthcare Conference 2
... Abaxis, Inc. (NasdaqGS: ABAX), a medical products company manufacturing ... chief operations officer, will present at ThinkEquity,s Second Annual ... a.m. ET. The conference will be held at The ... About AbaxisAbaxis develops, manufactures, markets and sells portable blood ...
... presented this week at the International Federation of Clinical ... lower diagnostic threshold for troponin improves clinical outcomes and ...  Troponin is a protein found inside of heart cells ... or reduced blood supply.   Cardiac troponin ...
Cached Medicine Technology:Study Shows Improved Patient Management and Outcome Using Abbott's Sensitive Troponin Assay 2Study Shows Improved Patient Management and Outcome Using Abbott's Sensitive Troponin Assay 3Study Shows Improved Patient Management and Outcome Using Abbott's Sensitive Troponin Assay 4
For Atrial Mapping. Biosense Webster offers a complete line of specialty 20-pole catheters. The CRISTA CATH 20-pole deflectable catheter is designed for positioning along the crista terminals....
... Inquiry H Steerable Catheter. Steerable ... variety of designs and a ... stability. 10 to 24 electrodes, ... inactive and active tip electrodes, ...
Sophisticated DecaPolar Catheters provide enhanced recording and mapping quality....
... Torqr Quadripolar Braided Shaft ... The Medtronic CardioRhythm Torqr ... use in diagnostic electrophysiologic ... designed for recording intracardiac ...
Medicine Products: