Navigation Links
Study finds tiny, targeted drug particles may be effective in treating chronic diseases
Date:3/20/2013

Doses of medicine 100,000 times smaller than the diameter of a human hair prevent the tissue damage associated with atherosclerosis and other chronic diseases in mice. As part of a National Institutes of Health-sponsored project led by Zahi Fayad, PhD, of the Icahn School of Medicine at Mount Sinai, researchers found that these nanomedicines are able to home specifically to damaged tissue to repair it. This study was published online this week in Proceedings of the National Academy of Sciences.

Inflammation is the body's natural defense mechanism against invading organisms and tissue injury. When under attack by a pathogen such as a virus, the body mounts an immune response that causes inflammation to clear the attacker so the body can return to a healthy state. Scientists believe that in chronic diseases like heart disease or diabetes, the body mounts a prolonged immune response resulting in chronic inflammation and tissue damage. Since the level of inflammation in these diseases is very high, targeted therapeutic solutions are required to help keep inflammation contained.

"Numerous studies have shown that inflammation is the foundation for many chronic diseases, and we need therapies that help resolve the tissue damage that results from that inflammation," said Dr. Fayad, who is the Director of the Translational and Molecular Imaging Institute and Professor of Radiology and Medicine at The Mount Sinai Medical Center. "Nanomedicine is the next frontier in successfully treating and preventing the progression of these conditions without the side effects that come from standard drug therapy."

Researchers at Brigham and Women's Hospital (BWH), Columbia University Medical Center, Massachusetts Institute of Technology, and Mount Sinai developed a nanoparticle that mimics a protein that is critical to the resolution of inflammation in the body. The research team incorporated the nanoparticle into a molecule consisting of three parts: one that controlled the release of the drug into the inflamed tissue, another that controlled how long it circulates in the system, and another that directs the drug to the damaged tissue in the vascular wall, where it binds to receptors in white blood cells.

"The beauty of this approach is that it takes advantage of nature's own design for preventing inflammation-induced damage, which, unlike many other anti-inflammatory strategies, does not compromise host defense and promotes tissue repair," said Ira Tabas, MD, PhD, physician-scientist at Columbia University Medical Center and co-senior author of this study.

The study showed that once the molecule was injected into mice, it homed to the injured tissue, where the drug was released into the vasculature as needed and circulated through the system, resolving the inflammation. These new developments have led the researchers to start investigating the potential of these pro-resolving nanomedicines for their effects on shrinking atherosclerotic plaques in humans.

"The development of self-assembled targeted nanoparticles which are capable of resolving inflammation has broad application in medicine including the treatment of atherosclerosis," said Omid Farokhzad, MD, physician-scientist at BWH, and a co-senior author of this study.


'/>"/>

Contact: Mount Sinai Press Office
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Related medicine news :

1. Anxiety, Depression May Triple Risk of Death for Heart Patients: Study
2. Plans to Penalize Non-Emergency Use of ERs Flawed: Study
3. Study could aid development of new drugs to treat gout
4. A Third of U.S. Seniors Die With Dementia, Study Finds
5. Gene Mutations Appear Key to Childhood Leukemia Risk, Study Says
6. First of its kind study in Canada looks at who is taking aspirin to prevent heart attack or stroke
7. Switch to Skim Milk Wont Prevent Toddlers Obesity: Study
8. Fewer Kids Getting Hurt in Most Sports, Study Finds
9. Black Children Less Likely to Get Antibiotics: Study
10. BioPharm Systems Unveils Study Data Mapper to Simplify the Preparation and Reporting of Clinical Data
11. Discounts on purchases of healthy foods can improve diets, study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... 2016 , ... Quality metrics are proliferating in cancer care, and are derived ... eye of the beholder, according to experts who offered insights and commentary in the ... Care. For the full issue, click here . , For the American Society ...
(Date:6/26/2016)... ... 2016 , ... Pixel Film Studios Released ProSlice Levels, a Media Slicing Effect ... videos a whole new perspective by using the title layers in ProSlice Levels ... , ProSlice Levels contains over 30 Different presets to choose from. FCPX ...
(Date:6/26/2016)... Charlotte, NC (PRWEB) , ... June 26, 2016 , ... Brent Kasmer, a legally blind ... able to be personalized through a fitness app. The fitness app plans to fix the ... solutions currently only offer a one size fits all type program , They ...
(Date:6/25/2016)... ... 2016 , ... Experts from the American Institutes for Research ... June 26-28, 2016, at the Hynes Convention Center in Boston. , AIR experts ... planning, healthcare costs and patient and family engagement. , AIR researchers will be ...
(Date:6/25/2016)... ... 25, 2016 , ... The temporary closing of Bruton Memorial Library on June 21 due to ... a new, often overlooked aspect of head lice: the parasite’s ability to live away from ... common occurrence, but a necessary one in the event that lice have simply gotten out ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 ... "Pharmaceutical Excipients Market by Type (Organic Chemical (Sugar, ... Formulation (Oral, Topical, Coating, Parenteral) - Global Forecast to ... The global pharmaceutical excipients market ... at a CAGR of 6.1% in the forecast period ...
(Date:6/23/2016)... 23, 2016 Capricor Therapeutics, ... a biotechnology company focused on the discovery, development ... patient enrollment in its ongoing randomized HOPE-Duchenne clinical ... 50% of its 24-patient target. Capricor expects the ... quarter of 2016, and to report top line ...
(Date:6/23/2016)... RIDGE, Ill. and INDIANAPOLIS ... of students receiving a Lilly Diabetes Tomorrow,s Leaders Scholarship ... The 2016 scholarship winners, announced today online at ... to let type 1 diabetes stand in the way ... Diabetes has supported the Foundation,s scholarship program since 2012, ...
Breaking Medicine Technology: