Navigation Links
Study finds that carbon monoxide can help shrink tumors and amplify effectiveness of chemotherapy
Date:12/4/2013

BOSTON -- In recent years, research has suggested that carbon monoxide, the highly toxic gas emitted from auto exhausts and faulty heating systems, can be used to treat certain inflammatory medical conditions. Now a study led by a research team at Beth Israel Deaconess Medical Center (BIDMC) shows for the first time that carbon monoxide may also have a role to play in treating cancer.

The surprising new findings, described in the December issue of the journal Cancer Research, show that in cell culture and animal models carbon monoxide (CO) can both prevent tumor growth in prostate and lung cancers and can amplify the effectiveness of chemotherapy 1,000-fold while sparing noncancerous tissue from chemo's sometimes debilitating side effects.

"We found that in small, carefully controlled doses, CO not only mimicked the effects of chemotherapy agents by blocking proliferation of cancer cells, but also amplified the toxic effects of the chemotherapy drugs doxorubicin and camptothecin to accelerate cancer cell death," says senior author Leo Otterbein, PhD, an investigator in the Transplant Institute in BIDMC's Department of Surgery and Associate Professor of Surgery at Harvard Medical School. "Importantly and rather unique is that CO also helped to protect normal tissue from chemotherapy, which is an unfortunate side effect of the treatments."

The new discovery appears to hinge on CO's ability to switch the metabolic state of cancer cells so that tumors essentially work themselves to death. "There are fundamental differences in the metabolism of normal cells and cancer cells," explains Otterbein. "Cancer cells are able to alter their metabolism in processing sugars and other energy sources, which enable them to rapidly proliferate and spread. This shift in metabolism is known as the Warburg Effect. Our findings indicate that CO essentially induces an 'anti-Warburg' effect, rapidly fueling cancer cell bioenergetics by compelling th
'/>"/>

Contact: Bonnie Prescott
bprescot@bidmc.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Study Suggests Vaccine May Help Kids With Brain Cancer
2. Study reveals how cancer drug causes diabetic-like state
3. Coffee Drinking in Pregnancy Wont Lead to Sleepless Baby: Study
4. Lower GI problems plague many with rheumatoid arthritis, Mayo Clinic study finds
5. Veggies Like Broccoli, Cabbage May Help Fight Breast Cancer: Study
6. No Added Cancer Risk From Hip Replacement Materials: Study
7. Reported Decline in U.S. Pneumonia Deaths May Be False: Study
8. Early Study Finds Some Promise for Lung Cancer Vaccine
9. Narcissists Often Ace Job Interviews, Study Finds
10. Sexual objectification of female artists in music videos exists regardless of race, MU study finds
11. Soy may alleviate hot flashes in menopause, large-scale study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Hollywood, California (PRWEB) January 22, 2015 The City ... 2015 at 10 a.m., to commemorate the 42nd anniversary of the ... United States. , “It’s been 42 years since the Roe vs. ... choose is still as present as ever,” said City of West ...
(Date:1/22/2015)... The Incredible Bulk is a revolutionary method ... lean muscle by up to 30lbs in less than 12 ... HealthyandFitZone.com’s Stan Stevenson, prompting an investigative review. , “Our ... scientific diet formula that allows the body to pack on ...
(Date:1/22/2015)... 2015 Juvent Sports ( http://www.juventsports.com ) ... PGA Merchandise Show to bestow a Juvent Sports Achievement ... golfer, Arlene McKitrick. The award commemorated and congratulated McKitrick ... win. She won her first amateur tournament in 1979 ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Carinsurancesavings.biz has released ... accidental death and dismemberment insurance . , Purchasing an ... can be very advantageous. This type of rider provides benefits ... dismemberment can be considered a lesser form of life insurance. ...
(Date:1/22/2015)... Palm City, Florida (PRWEB) January 22, 2015 ... use cold therapy machine with patented IsoTube design to treat ... has introduced the most progressive and easy to use ... help treat post-operative and sports related orthopedic and muscle injuries. ...
Breaking Medicine News(10 mins):Health News:The Incredible Bulk: Review Examining Ben Pakulski’s Brand New Bulking Muscle Building Diet Program Released 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 3Health News:Accidental Death and Dismemberment Insurance Can Be Purchased at Low Prices Online 2Health News:IsoComforter Introduces Best of Class Cold Therapy Product to the Worldwide Market 2
... (HealthDay News) -- Women, but not men, with post-traumatic ... hormone, new research shows. The hormone -- pituitary ... central nervous system activity, metabolism, blood pressure, pain sensitivity ... in the Feb. 24 issue of Nature , ...
... HealthDay Reporter , WEDNESDAY, Feb. 23 (HealthDay ... pain -- an increasingly controversial treatment that has exploded ... to higher rates of permanent disability for worker,s compensation ... finds. Researchers randomly selected 725 people with low ...
... collaboration is bringing surgical patients closer to having ... trial, patients given neosaxitoxin, a new local anesthetic ... and recovered about two days sooner than those ... on this finding, Children,s Hospital Boston, a co-investigator ...
... of breast cancer survivors battle persistent fatigue, a Michigan ... a technique where physical pressure is applied to acupuncture ... can help alleviate symptoms. Gwen Wyatt will study ... two acupressure treatments on persistent cancer-related fatigue, a state ...
... - While studying one tumor-suppressing protein, Cheryl Walker,s research ... Center came across a separate surprise. They found another ... moonlighting out in the cell,s cytoplasm. Following up ... protein ATM has a second job controlling and killing ...
... San Francisco, CA February 22, 2011 The ... million in research grants as part of its Mobilizing ... populations with chronic diseases through the use of mobile-phone ... $250,000 each, will support studies on diabetes care and ...
Cached Medicine News:Health News:Spinal Fusion Surgery May Leave Some Back Pain Patients Worse Off: Study 2Health News:Spinal Fusion Surgery May Leave Some Back Pain Patients Worse Off: Study 3Health News:New long-acting local anesthetic derived from algae effectively blocks pain in surgical patients 2Health News:New long-acting local anesthetic derived from algae effectively blocks pain in surgical patients 3Health News:Acupressure shows promise in relieving fatigue in cancer survivors 2Health News:UT MD Anderson discovery wins 2010 Cozzarelli Prize 2Health News:McKesson Foundation awards $1.3 million in 6 Mobilizing for Health Research grants 2
(Date:1/22/2015)... , Jan. 22, 2015  ViewRay™, a privately held ... into an exclusive distributor agreement with ITOCHU Corporation (Tokyo ... therapy system for the treatment of cancer in ... system, is the world,s first and only MRI-guided radiation ...
(Date:1/22/2015)... 22, 2015  Amgen (NASDAQ: AMGN ) today announced that ... results on Tuesday, Jan. 27, 2015, after the close of the ... call with the investment community at 2 p.m. PT. Participating in ... chairman and chief executive officer, and other members of Amgen,s senior ...
(Date:1/22/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/x3hp3g/microbiology ... "Microbiology Testing/Clinical Microbiology Market by Product, Clinical Application ... report to their offering. Clinical ... for the detection of infectious diseases. The respiratory ...
Breaking Medicine Technology:ITOCHU Named the Exclusive Distributor for ViewRay's MRI-Guided Radiation Therapy System in Japan 2Amgen Announces Webcast of 2014 Fourth Quarter and Full Year Financial Results 2Global Microbiology Testing/Clinical Microbiology (Instrument, Analyzer, Incubator, Kit, Microscope, Molecular Diagnostics) Market - Forecast to 2019 2Global Microbiology Testing/Clinical Microbiology (Instrument, Analyzer, Incubator, Kit, Microscope, Molecular Diagnostics) Market - Forecast to 2019 3
... Reached in Key Lung Compartments, REINACH and ... Ltd. today announced promising,results of "first-in-man" studies ... a total of 19 healthy male,volunteers. , ... using Microdosing,for the determination of drug concentrations ...
... /PRNewswire-FirstCall/ -- ADVENTRX,Pharmaceuticals, Inc. , a ... commercializing proprietary product,candidates for the treatment ... that results from preclinical studies of ... (5-FU),and capecitabine (Xeloda(R)), an oral prodrug ...
Cached Medicine Technology:Arpida Announces Promising Results of "First-In-Man" Studies With,AR-709 2Arpida Announces Promising Results of "First-In-Man" Studies With,AR-709 3Arpida Announces Promising Results of "First-In-Man" Studies With,AR-709 4Arpida Announces Promising Results of "First-In-Man" Studies With,AR-709 5ADVENTRX to Present CoFactor Multiagent Therapy Data at AACR Annual,Meeting 2ADVENTRX to Present CoFactor Multiagent Therapy Data at AACR Annual,Meeting 3
... drainage from the ureteropelvic junction to ... packages. Intended for one-time use. CAUTION: ... Sof-Flex® stents must not remain indwelling ... stents must not remain indwelling more ...
... Pigtail Ureteral Stents have an exclusive ... migration. They also feature unique Tecoflex® ... savings. Each Classic Double PigTail Ureteral ... PigTail Ureteral Stent with attached braided ...
The Needle Loading Platform / Shield is designed to provide superior operator shielding during the loading of prostate implant needles with iodine or palladium seeds. It is constructed of 3/8" alumin...
The seed alignment tray aligns seeds and spacers for easy access to be picked up by the SeedVac™. It also interfaces with the seed sterilization and sorting tray for protection from radiation....
Medicine Products: