Navigation Links
Study finds that cancer-causing gene crucial in stem cell development
Date:9/2/2010

cells differentiate into more specific cell types. In the new research, Dalton's team showed that Myc sustains the important pluripotency process by repressing a "master regulator" gene called GATA6.

"Pluripotency is the inherent property of a cell to create all cell types, from an embryo to an adult organism," said Dalton. "It's an extremely important biological process, and knowing how it is controlled is crucial not only from a basic developmental perspective but also so that we can harness the potential of stem cells for the development of therapies, including those for diabetes, cardiovascular disease and a range of neurological disorders. Through a detailed understanding of early development, we hope to apply this information so that pluripotent stem cells can be differentiated into therapeutically useful cell types. These cells can then be used in a clinical setting to cure degenerative diseases and treat acute injury."

The finding that Myc inhibits GATA6 came as a big surprise to the Dalton team and points out that researchers have only seen the tip of the "molecular iceberg" in terms of what Myc does in stem cells. It now seems likely that understanding Myc's role in further detail will reshape current ideas about the basic biology of stem cells.

Dalton's new work addressed the uncertainty about how Myc maintains the pluripotency of stem cells by examining what happens when two forms of Mycc-Myc and N-Mycare inactivated in pluripotent stem cells. What he found was that either c- or N-Myc is sufficient to maintain pluripotency, but that the absence of both triggers the differentiation of pluripotent stem cells. Myc is therefore acting as a "brake" to restrain differentiation. When the "differentiation brake" is removed, cells lose their stem cell properties, and, potentially, they can become any one of over a hundred different cell types.

Pluripotent stem cells can now be made from skin fibroblasts and even from blood sa
'/>"/>

Contact: Stephen Dalton
sdalton@uga.edu
706-542-9857
University of Georgia
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Despite Treatment, Employees with Depression Generate Higher Absentee Costs, According to Thomson Reuters Study
2. American Council on Exercise (ACE) Study Reveals Kettlebells Provide Powerful Workout in Short Amount of Time
3. TV drama can be more persuasive than news program, study finds
4. Study carried out into biological risks of eating reptiles
5. Neuroimaging study may pave way for effective Alzheimers treatments
6. Study finds racial gaps continue in heart disease awareness
7. Luth Researchs IndicatorEDG(TM) Study Finds Americans Hopes of Achieving Their Dreams Are Fading
8. First blinded study of venous insufficiency prevalence in MS shows promising results
9. Soothing infants with food focus of childhood obesity study
10. People with anxiety disorder less able to regulate response to negative emotions, study shows
11. American Heart Association Rapid Access Journal Report: Study Finds Racial Gaps Continue in Heart Disease Awareness, Low Knowledge of Heart Attack Warning Signs Among Women
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... Responding to the call to ... to an increasingly diverse patient population, three leading ... expertise to the publication of a new textbook ... and Cultural Competence in Health Care: A Systems ... a professor in the Management Division at the ...
(Date:7/30/2014)... returning National Guard soldiers were more likely to ... life setbacks, including job loss, legal problems, divorce, ... military families. Results of the study by researchers ... are published online in the American Journal ... a major concern for reservists returning home. Nearly ...
(Date:7/30/2014)... Recently, the Kansas Health Image ... start-up fees for hospitals and clinics who request ... September 30, 2014. , Modern healthcare providers are ... complexity of digital patient information, often referred to ... data silos. , Traditional health IT solutions, including ...
(Date:7/30/2014)... 2014 MyMobileUniversity (MMU) is a global ... an award winning mobile and web based learning company ... 2004. , MyMobileUni.com’s platform makes it a one-stop centre ... has links to the world’s leading Massive Open Online ... experts from all over the world who have content ...
(Date:7/30/2014)... Daily Gossip mentions that the "Panic Away" method developed ... stop anxiety and eliminate all associated symptoms. It has been ... 150,000 people in getting their lives back. , The Panic ... system that will teach sufferers different techniques on how to ... to access, as it is available in a complex guide. ...
Breaking Medicine News(10 mins):Health News:NLN CEO Co-Authors Textbook to Advance Diversity and Cultural Competence Across Health Care Professions 2Health News:NLN CEO Co-Authors Textbook to Advance Diversity and Cultural Competence Across Health Care Professions 3Health News:Vets' alcohol problems linked to stress on the home front 2Health News:Kansas Health Image Exchange Announces Open Enrollment; Virtual CD from Offsite Image Solves Problems with Unreadable Patient Images, Delayed Diagnosis 2Health News:Kansas Health Image Exchange Announces Open Enrollment; Virtual CD from Offsite Image Solves Problems with Unreadable Patient Images, Delayed Diagnosis 3Health News:MyMobileUniversity Inviting Individuals, Who Are Passionate about the Universal Right to Education, to Come on Board as Goodwill Ambassadors 2Health News:MyMobileUniversity Inviting Individuals, Who Are Passionate about the Universal Right to Education, to Come on Board as Goodwill Ambassadors 3Health News:Panic Away Review Reveals How to Stop Anxiety 2
... (OTC,Bulletin Board: SNKTY), a Life Sciences company engaged ... of healthy aging, today announced,that Dr. Neil Sadick ... the American Academy of Dermatology in San Antonio, ... Dr. Sadick, a prominent New York,dermatologist, outlined the ...
... patients receiving aggressive drug therapy to cut blood sugar ... large North American trial designed to aggressively lower the ... heart disease has been halted because of an unexpected ... , Federal health officials announced Wednesday that 257 ...
... Senetek PLC (OTC,Bulletin Board: SNKTY), a Life ... target the science of healthy aging, today announced,the ... ., Mr. Frank Massino, Senetek,s Chairman and ... greater visibility to Senetek at this,significant time in ...
... Introduced during the much anticipated ... America., TORONTO, Feb. 6 /PRNewswire/ - IgeaCare Systems ... introduction of,ConversationPRO(TM) for Microsoft Dynamics CRM 4.0., "Contact ... CRM,screen launch populated with the caller contact information, along ...
... ST. LOUIS, Feb. 6 Cejka Search, ... firm, recently announced that,several of its leaders ... Retention Strategies Audio Conference and the American,College ... Leadership., Audio Conference: Retention Strategies to ...
... CHAPEL HILL, N.C., Feb. 6 From ... improvements, customer feedback has,enhanced services, products and ... recent study by Best Practices, LLC,s Global ... initiatives is key,to better aligning the customer ...
Cached Medicine News:Health News:Dr. Neil Sadick Presents on Pyratine-6(TM) at the Annual Meeting of the American Academy of Dermatology 2Health News:Deaths Halt Part of Large Diabetes Trial 2Health News:Deaths Halt Part of Large Diabetes Trial 3Health News:Deaths Halt Part of Large Diabetes Trial 4Health News:Senetek PLC Announces Launch of New Website 2Health News:Microsoft Dynamics CRM 4.0 Users now can include Telephony and Call Recording features by adding ConversationPRO(TM) from VoiceGate, a Division of IgeaCare Systems Inc. 2Health News:Microsoft Dynamics CRM 4.0 Users now can include Telephony and Call Recording features by adding ConversationPRO(TM) from VoiceGate, a Division of IgeaCare Systems Inc. 3Health News:Cejka Search Experts Present Latest Developments in Physician Retention and CEO Leadership Skills 2Health News:Customer Experience Conference, Feb. 25-27: Sharing New Insights on Winning Customer Loyalty 2
(Date:7/30/2014)... YORK , July 30, 2014 ACCESS ... for oncology supportive care, announced that its novel product ... in an article on OncLive.com titled, "Study Finds Mouth ... Cancers."  Dr. Steve Sonis , a leading expert ... seen in the oncology community for evidence-based strategies for ...
(Date:7/30/2014)... 2014  Hospira, Inc. (NYSE: HSP ... and infusion technologies, today reported results for the ... for the quarter were $1.1 billion and adjusted* ... exclude specified items as described later in this ... U.S. Generally Accepted Accounting Principles (GAAP) basis, second-quarter ...
(Date:7/30/2014)... July 30, 2014   Epic Sciences, Inc. ... designs and develops novel diagnostics to personalize and ... today the completion of a $30 million Series ... investors RusnanoMedInvest (RMI) and Arcus Ventures, existing investors ... Investments, as well as undisclosed individual investors. With ...
Breaking Medicine Technology:Access Pharmaceuticals Featured On OncLive.com 2Access Pharmaceuticals Featured On OncLive.com 3Hospira Reports Second-Quarter 2014 Results 2Hospira Reports Second-Quarter 2014 Results 3Hospira Reports Second-Quarter 2014 Results 4Hospira Reports Second-Quarter 2014 Results 5Hospira Reports Second-Quarter 2014 Results 6Hospira Reports Second-Quarter 2014 Results 7Hospira Reports Second-Quarter 2014 Results 8Hospira Reports Second-Quarter 2014 Results 9Hospira Reports Second-Quarter 2014 Results 10Hospira Reports Second-Quarter 2014 Results 11Hospira Reports Second-Quarter 2014 Results 12Hospira Reports Second-Quarter 2014 Results 13Hospira Reports Second-Quarter 2014 Results 14Hospira Reports Second-Quarter 2014 Results 15Hospira Reports Second-Quarter 2014 Results 16Hospira Reports Second-Quarter 2014 Results 17Hospira Reports Second-Quarter 2014 Results 18Hospira Reports Second-Quarter 2014 Results 19Hospira Reports Second-Quarter 2014 Results 20Hospira Reports Second-Quarter 2014 Results 21Hospira Reports Second-Quarter 2014 Results 22Hospira Reports Second-Quarter 2014 Results 23Hospira Reports Second-Quarter 2014 Results 24Hospira Reports Second-Quarter 2014 Results 25Hospira Reports Second-Quarter 2014 Results 26Hospira Reports Second-Quarter 2014 Results 27Hospira Reports Second-Quarter 2014 Results 28Hospira Reports Second-Quarter 2014 Results 29Hospira Reports Second-Quarter 2014 Results 30Hospira Reports Second-Quarter 2014 Results 31Epic Sciences Announces Series C Financing to Advance Essential Cancer Diagnostics for Personalized Medicine 2Epic Sciences Announces Series C Financing to Advance Essential Cancer Diagnostics for Personalized Medicine 3
For the quantitative in vitro determination of Uric Acid in serum, plasma and urine...
The BUN method used on the Dimension clinical chemistry system is an in vitro diagnostic test intended for the quantitative determination of urea nitrogen in serum, plasma and urine....
For the quantitative in vitro determination of K-glutamyl transferase (K-GT) in serum or plasma....
The CK method used on the Dimension clinical chemistry system is an in vitro diagnostic test intended for the quantitative determination of creatine kinase activity in serum and plasma...
Medicine Products: