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Study finds reproductive health effects from low doses of bisphenol-A
Date:6/17/2009

stage that takes place for humans when they are still in the womb.

While exposure to the lowest dose, 50 g /kg, resulted in early onset of puberty in the rats, exposure to higher dose had more complicated results.

When exposed to the higher 50 mg/kg dose, the female rats developed cyst-like formations in their ovaries. The ovaries also developed fewer so-called "corpora lutea" structures than normal. Corpora lutea appear after ovulation and are essential to fertility because they produce a hormone called progesterone. If an ovary does not produce enough progesterone, it is impossible for a female to sustain a pregnancy. The lack of corpora lutea likely indicate that the female rats were no longer ovulating and would probably be infertile.

Exposure to the higher 50 mg/kg dose also resulted in the female rats prematurely losing their estrous cycle. The researchers determined this by observing a lack of change in the skin cells of the female reproductive tract of the rats across the estrous cycle. These cellular changes indicate a normal estrus cycle.


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Contact: Matt Shipman
matt_shipman@ncsu.edu
919-515-6386
North Carolina State University
Source:Eurekalert

Page: 1 2

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