Navigation Links
Study finds reformulated ER Oxycodone abuse rates are significantly lower than original ER Oxycodone
Date:11/14/2012

  • Aims of this study were to assess 1) whether the rates of abuse of extended-release (ER) oxycodone (OxyContin) decline following introduction of reformulated ER oxycodone (ORF), and 2) whether ORF is less likely to be abused through non-oral routes of administration that require tampering
  • Researchers obtained data from 140,496 individuals assessed for substance abuse treatment at 357 treatment centers
  • Findings were consistent with the goals for a tamper resistant formulation, however further research is needed to determine the persistence and generalizability of these initial findings

This is the first epidemiological study to examine the public health impact of a tamper resistant extended-release oxycodone (ORF). ER oxycodone was reformulated with physicochemical barriers to crushing and dissolving intended to reduce abuse through non-oral routes of administration. Manufacturer shipments of original ER oxycodone stopped on August 5, 2010, and ORF shipments started August 9, 2010. During the first 20 months following ORF introduction, it was abused significantly less than the original ER oxycodone when measured by 8 outcome measures, particularly through non-oral routes of administration that require tampering (such as injection, snorting, smoking).

More information on this study can be found in the article, "Abuse rates and routes of administration of reformulated extended-release oxycodone: initial findings from a sentinel surveillance sample of individuals assessed for substance abuse treatment" published in the November 2012 issue of the Journal of Pain.

A sentinel surveillance sample of 140,496 individuals assessed for substance abuse treatment at 357 treatment assessment centers across the country between June 1, 2009 and March 31, 2012 was examined for abuse through oral and non-oral specific routes of administration for ER oxycodone before and after ORF was introduced. Significant reductions were observed in eight outcome measures of ORF versus the original ER oxycodone. Data were collected by Inflexxion's proprietary NAVIPPRO (National Addictions Vigilance Intervention and Prevention Program) system, which includes a network of hundreds of substance abuse assessment centers in the US. The NAVIPPRO data monitoring system tracks prescription opioid and stimulant drug abuse patterns and estimate relative rates of abuse of specific prescription products.

"The study's findings, from the first 20 months following introduction of a tamper-resistant formulation like ORF, suggest that such formulations can significantly impact abuse patterns among a sentinel surveillance sample of individuals assessed for substance use problems," says first author and co-creator of NAVIPPRO, Stephen F. Butler, PhD, Senior Vice President and Chief Science Officer at Inflexxion. "Introduction, on a large scale, of ORF, provided a natural experiment, where abusers and potential abusers were exposed to this new kind of formulation. Since the NAVIPPRO data streams allow nearly real-time observations to be made, we were able to get an initial view of abuse-pattern changes quickly. These findings corroborate results from pre-approval pharmacokinetic and abuse liability studies as well as from laboratory extraction studies that demonstrated reduced abuse potential in controlled environments."

"While abuse of prescription opioids continues to be a significant public health concern, these findings suggest reformulated ER oxycodone thus far has been successful in deterring tampering relative to the original formulation," says co-author Simon Budman, PhD, founder and CEO of Inflexxion. "This study serves as a proof of concept that tamper resistant formulations may help reduce overall abuse and abuse by non-oral routes of administration. Further research is needed to determine whether these effects persist over time and whether similar effects are observed in other populations that abuse or misuse prescription opioids."


'/>"/>

Contact: Elsbeth McSorley
emcsorley@inflexxion.com
617-614-0369
Inflexxion, Inc.
Source:Eurekalert

Related medicine news :

1. Month of Birth Might Help Determine MS Risk, Study Suggests
2. Study Reveals Gender Gap in Spotting Depression
3. Patients More Likely to Survive In-Hospital Cardiac Arrest Today: Study
4. Bright Light at Night Could Up Depression Risk, Mouse Study Suggests
5. Kids Generosity May Depend on Whos Watching: Study
6. Schizophrenia Patients Who Take Antipsychotics Live Longer, Study Says
7. Worlds largest respiratory genetics study launches on World COPD Day
8. Synthetic Skin Heals Itself With a Touch, Study Shows
9. Migraine Sufferers Show More Brain Changes Than Others: Study
10. Kids Headaches Rarely Due to Vision Problems, Study Finds
11. Study demonstrates that earlier end of life care discussions are linked to less aggressive care in final days of life
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/23/2017)... , ... February 23, 2017 , ... ... publication and community for those in the fight against cancer, has produced a ... their success. HRA will release top-line findings in a webinar, Defining Compassionate ...
(Date:2/23/2017)... ... 2017 , ... CALNOC, the nation’s first and only nursing quality indicators database ... Empowerment, Value and Collaboration – in Seattle, WA on October 23, 2017. , Dr. ... System in Seattle since 2000. In addition to his role at Virginia Mason, Dr. ...
(Date:2/23/2017)... Minneapolis MN (PRWEB) , ... February 23, 2017 , ... ... it is sending an expert sit stand solutions representative to the Minneapolis Home and ... 5. Location for the event that is garnering national attention is the Minneapolis Convention ...
(Date:2/22/2017)... ... February 22, 2017 , ... ... of a new healthcare contact center in Georgia, PENETRON Specialty Products (PSP) provided ... nation’s largest healthcare systems recently invested $51 million to purchase and renovate the ...
(Date:2/22/2017)... ... February 22, 2017 , ... Stem cell therapy has made ... is so cutting edge, in fact, the U.S. Food and Drug Administration (FDA) ... successful patient outcomes in certain clinical stem cell procedures have shown that this ...
Breaking Medicine News(10 mins):
(Date:2/23/2017)... , February 23, 2017 The fast-growing ... the United States . According to the 2017 ... industry is expected to create 283,422 jobs by 2020, with ... over the next four years. The accelerating pace of cannabis ... growth of legal cannabis market, which will further create more ...
(Date:2/23/2017)... 2017 The top three players ... Healthcare, Koninklijke Philips N.V., and Schiller. Collectively, these companies ... market in 2015. Strong product portfolio and a monumental ... be aiding these players remain leaders in the fragmented ... in the global market are likely to focus on ...
(Date:2/23/2017)... Feb. 23, 2017   SeraCare Life Sciences ... in vitro diagnostics manufacturers and clinical laboratories, is ... Implementation of NGS-Based Tests" to be hosted by ... at 11am Eastern Standard Time (US). ... the need for improved performance and global standardization ...
Breaking Medicine Technology: