Navigation Links
Study finds preterm birth clinic attendence leads to major reduction in infant disability

SAN FRANCISCO (February 11, 2011) In a study to be presented today at the Society for Maternal-Fetal Medicine's (SMFM) annual meeting, The Pregnancy Meeting , in San Francisco, researchers will present findings that show that when women at high risk for preterm birth participated in a preterm birth prevention clinic, more women delivered full term babies and there were fewer cases of infant morbidity.

The National Center for Health Statistic reports that in 2008, 12.3% of babies were born prematurely. Women who have had a prior preterm birth are at high risk to have another one. In 2008, Intermountain Healthcare created a preterm birth (PTB) prevention clinic to focus care for this high-risk population.

"We wanted to take a very aggressive approach to treating women with a history of preterm birth,' said Sean Esplin, M.D., of Intermountain Healthcare and one of the studies authors. "We gathered together the best treatments for women at high risk for preterm labor and administered them in a systematic way." He continued, "Then we designed a study to see if the intervention leads to better results in future pregnancies."

Esplin and his colleagues conducted a retrospective review of women with a single, non-anomalous fetus and ≥1 documented previous spontaneous PTB < 35 wks. Women enrolled in a PTB Prevention Clinic were compared with women identified from a contemporary large perinatal database (with ≥ 1 documented PTB < 35 wks followed by ≥ 1 subsequent pregnancies) who received Usual-Care. The PTB Prevention Clinic was consultative only and included three prescribed visits with a maternal fetal-medicine specialist and standardized management and counseling. All PTB Prevention Clinic patients were offered 17 alpha-hydroxyprogesterone caproate (17OHPC) and were followed with serial cervical-lengths (CL); recommendations for liberal antenatal corticosteroid and tocolytic use were also made. Usual-Care patients were managed by their primary obstetrician. The primary outcome was recurrent PTB. Data were analyzed by chi-square and Student's t-test.

Two hundred and thirty-two patients (70 PTB Prevention Clinic and 162 Usual-Care patients) met inclusion criteria. Groups had similar previous pregnancy characteristics. PTB Prevention Clinic patients had increased utilization of resources (including more cervical length ultrasounds and higher rates of use of prophylactic 17OHPC) and delivered at later gestational ages. Rates of NICU admission were similar between groups (44.3% vs. 40.7%, p=0.62). However, rates of major neonatal morbidity (diagnosis of NEC, BPD, IVH, sepsis, or death) were lower among PTB Prevention Clinic neonates (5.3% vs. 15.4%, p=0.025).

The study showed that among this high-risk population, referral to a consultative PTB Prevention Clinic (with standardized counseling, management recommendations, and close surveillance) resulted in a reduction in the rate of recurrent PTB prior to 37 weeks, lead to an average of a one week longer pregnancy, and reduced the rates of major neonatal morbidity.

"The study showed that participants in the preterm birth prevention clinic had a 28 percent reduction in the risk of recurrent spontaneous preterm birth, as well as reductions in infant complications and short term disabilities," said Tracy Manuck, M.D., one of the study's authors. "These are significant improvements and should lead more medical facilities to think about creating similar programs."


Contact: Vicki Bendure
Society for Maternal-Fetal Medicine

Related medicine news :

1. Study finds even with fetal lung maturity, babies delivered prior to 39 weeks are at risk
2. Study examines phenomenon of women caring for ex-husbands
3. LED products billed as eco-friendly contain toxic metals, study finds
4. Coastal Canadians living in high-risk neighborhoods in poorer health: Study
5. Obesity Tied to Education, Income, but Not Suburbia: Study
6. Study finds that folate does not offer protection against preterm delivery
7. Study finds magnesium sulfate may offer protection from cerebral palsy
8. Study finds women used 30 percent less analgesia during labor when self-administered
9. Mouse Study Suggests New Clues to Celiac Disease
10. Many Breakthrough Drugs Come From Publicly Funded Research: Study
11. Johns Hopkins School of Medicine grants $5 million to study cognitive disorders
Post Your Comments:
(Date:11/25/2015)... ... ... Many people know of the common symptoms of low thyroid hormone (also ... many people who find their cholesterol levels and weight are creeping up are more ... they don’t have any of the other symptoms. , Thyroid hormone plays a major ...
(Date:11/25/2015)... , ... November 25, 2015 , ... ... is offering lower prices in an early celebration of the early holiday shopping ... price of $29.95 each (normally $33.95 ea). Black Friday promotional pricing is in ...
(Date:11/24/2015)... ... ... New patients who wish to seek treatment for missing teeth can now ... Mississauga, ON practice. Dr. Williams has been providing dental service for over 34 years, ... teeth can lead to a variety of complications if they are not replaced quickly, ...
(Date:11/24/2015)... ... November 24, 2015 , ... In an article ... variables that determine which patients are or are not eligible for bariatric surgery. The ... BMI over 40, are more than 100 pounds overweight, or have a BMI of ...
(Date:11/24/2015)... ... , ... Preparing for the LDT Regulation:, CLIA Won’t Satisfy the FDA, ... FDA has long asserted that design and manufacture of Laboratory Developed Tests (LDTs) falls ... meet the device regulations. , Come up short in an inspection and the FDA ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... , November 25, 2015 /PRNewswire/ ... announced the addition of the  "Global ...  report to their offering.  ... the addition of the  "Global Drug ...  report to their offering.  --> ...
(Date:11/24/2015)...  Array BioPharma Inc. (Nasdaq: ARRY ) ... Ron Squarer , will present at the Piper ... public is welcome to participate in the conference ... Jaffray Annual Healthcare ConferencePresenter:  , Ron Squarer, Chief ... Eastern Time Webcast: , ...
(Date:11/24/2015)... , Nov. 24, 2015  DILON Diagnostics and ... signed an agreement for DILON to distribute GE,s Discovery ... the globe. The signing of this distribution agreement will provide ... Molecular Breast Imaging system and is considered an initial ... better healthcare solutions for clinicians and their patients. ...
Breaking Medicine Technology: