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Study finds post-transplant patients off steroids have fewer cardiovascular events
Date:5/7/2010

ned under conventional immunosuppression with steroids.

"With the summation of 10 years of work, we've been able to show that patients off corticosteroids have the same graft-function outcomes as patients on corticosteroids," says Alloway. "In addition, the patients off corticosteroids benefit from fewer cardiovascular events."

UC researchers are also presenting the results of continued studies on use of the cancer drug bortezomib in solid organ transplant recipients. Altogether, 10 abstracts on UC-led bortezomib work will be featured at the meeting.

In a study published in the December 2008 issue of Transplantation, UC director of transplantation E. Steve Woodle, MD, and his colleagues showed bortezomib, a cancer drug commonly used to treat cancer of the plasma cells, is effective in treating rejection episodes caused by antibodies that attack transplanted kidneys.

Now, says Alloway, UC is presenting data from the next logical series of studies on the drug's use in transplantation, including its effect on both late and early acute rejection and the desensitization of patients with high antibody levels pre-transplant.

In work presented by transplant pharmacy fellow Carlin Walsh, PharmD, investigators demonstrated the ability of bortezomib to significantly reduce the level of donor-specific antibodies when prior therapies have failed. Walsh received a Young Investigator Award from the American Society of Transplantation for the desensitization studies with bortezomib.

UC researchers are also reporting results of shared protocols on the bortezomib treatment for antibody-mediated rejection. After presenting their bortezomib findings at the 2009 ATC, UC researchers created the START collaborative to share standard of care treatment protocols for bortezomib therapies. Through the collaborative, transplant centers worldwide have requested this information to treat individual patients with a variety of solid organ transpla
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Contact: Katy Cosse
kathryn.cosse@uc.edu
513-558-0207
University of Cincinnati Academic Health Center
Source:Eurekalert

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