Navigation Links
Study finds pigs susceptible to virulent ebolavirus can transmit the virus to other animals
Date:5/12/2011

[EMBARGOED FOR MAY 13, 2011] Canadian investigators have shown that a species of ebolavirus from Zaire that is highly virulent in humans can replicate in pigs, cause disease, and be transmitted to animals previously unexposed to the virus. The findings are published in The Journal of Infectious Diseases and are now available online. (Please see below for a link to the embargoed study online.)

In order to prevent human outbreaks of Ebola hemorrhagic fever, it is important to identify animal species that replicate and transmit the virus to other animals and, potentially, people. Zaire ebolavirus, one of several species of the virus, has a fatality rate as high as 90 percent in humans. Antibodies to another species not associated with human disease, known as Reston ebolavirus, have been found in pig farmers in the Philippines, suggesting pigs may be able to transmit virulent ebolavirus to humans as well.

This study, led by Gary P. Kobinger, PhD, of the Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, and Hana Weingartl, PhD, of the National Centre for Foreign Animal Disease at the Canadian Food Inspection Agency, investigated whether Zaire ebolavirus, like Reston ebolavirus, could replicate and cause disease in pigs and be transmitted to other animals. Using domesticated pigs, the researchers first evaluated virus replication, pathogenicity, and shedding.

Following mucosal exposure to Zaire ebolavirus, the pigs replicated the virus in high amounts, mainly in the respiratory tract. Shedding of the virus from nasal mucosa was detected for up to 14 days post-infection, and severe lung disease was observed. The study also showed that the virus was transmitted to all previously unexposed pigs co-habiting with the infected animals.

The study authors suggest that domesticated pigs are susceptible to Zaire ebolavirus through mucosal infection and that the pigs' accompanying severe respiratory disease is associated with shedding of high viral loads into the environment, exposing uninfected pigs to the infection. In contrast to the systemic syndrome affecting multiple organs that often leads to shock and death in primates, they noted, the respiratory syndrome that develops in pigs could be mistaken for other porcine respiratory diseases.

In an accompanying editorial, Daniel G. Bausch, MD, MPH & TM, of the Tulane School of Public Health and Tropical Medicine in New Orleans, noted that the study's findings raise important questions for additional research on ebolavirus. The results described in the study are "cause for consideration, for further scientific study" but are not cause for panic, Dr. Bausch wrote.


'/>"/>

Contact: John Heys
jheys@idsociety.org
703-299-0412
Infectious Diseases Society of America
Source:Eurekalert

Related medicine news :

1. Despite Treatment, Employees with Depression Generate Higher Absentee Costs, According to Thomson Reuters Study
2. American Council on Exercise (ACE) Study Reveals Kettlebells Provide Powerful Workout in Short Amount of Time
3. TV drama can be more persuasive than news program, study finds
4. Study carried out into biological risks of eating reptiles
5. Neuroimaging study may pave way for effective Alzheimers treatments
6. Study finds racial gaps continue in heart disease awareness
7. Luth Researchs IndicatorEDG(TM) Study Finds Americans Hopes of Achieving Their Dreams Are Fading
8. First blinded study of venous insufficiency prevalence in MS shows promising results
9. Soothing infants with food focus of childhood obesity study
10. People with anxiety disorder less able to regulate response to negative emotions, study shows
11. American Heart Association Rapid Access Journal Report: Study Finds Racial Gaps Continue in Heart Disease Awareness, Low Knowledge of Heart Attack Warning Signs Among Women
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2017)... ... April 23, 2017 , ... Altura Communication Solutions, ... of Cisco Select certification and SMB specialization. Altura is now qualified to ... In earning the Select Certification, Altura fulfilled the training and exam requirements for ...
(Date:4/22/2017)... ... April 22, 2017 , ... ... PROSHRED® Security of Philadelphia its “Woman-Owned Small Business of the Year, ... providing information destruction , recycling, and compliance services to businesses throughout ...
(Date:4/22/2017)... Freedom, PA (PRWEB) , ... April 22, 2017 ... ... healthcare experience to his role as Vice President of Sales and Business Development ... of key GPO/IDN business partner engagements, business development, and strategic planning for the ...
(Date:4/21/2017)... , ... April 21, 2017 , ... An April 10 ... a pair of ancient teeth, which reveal a great deal about prehistoric ice-age dental ... sharp stone may have been used to remove decayed dental matter, and that teeth ...
(Date:4/21/2017)... ... April 21, 2017 , ... The staff at Palm Beach Face is proud to announce ... the 2017 London Marathon. Set to take place on April 23rd, the London Marathon has ... Schwartz will run as part of team EMPOWER, raising money for the international charity, Smile ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... , April 19, 2017 The Mobile X-Ray product ... a healthy CAGR during the forecast period Mobile ... the global digital mobile X-Ray devices market, which is estimated ... 2017, expanding at a CAGR of 7% over the forecast ... opportunity of more than US$ 100 Mn in 2017 over ...
(Date:4/19/2017)... April 19, 2017 Global Prostate Cancer ... on the prostate cancer therapeutics market analyzes the ... Increasing prevalence of prostate cancer, launch of promising ... development of new drugs & therapeutic biological products, ... due to lesser side effects are some of ...
(Date:4/19/2017)... , April 19, 2017  Sorrento Therapeutics, ... antibody-centric, clinical-stage biopharmaceutical company developing new treatments for ... the closing of its previously announced underwritten public ... at a public offering price of $2.00 per ... estimated offering expenses payable by Sorrento.  The net ...
Breaking Medicine Technology: