Navigation Links
Study finds outcomes of high-risk cancer operations in 80-year-olds worse than reported
Date:12/18/2007

CHICAGO (December 18, 2007) New research published in the December issue of The Journal of the American College of Surgeons shows that outcomes of high-risk cancer operations in 80-year-olds are considerably worse than reported in case studies and published survival statistics, which may lead to unrealistic expectations about the safety of these operations in the elderly. With this limited information, elderly patients and their physicians may have difficulty accurately assessing the risks and benefits of major cancer operations.

An increasing number of the very elderly are undergoing major cancer operations as the population ages. Between 1994 and 2003, total surgical discharges after lung, esophageal and pancreatic resection in patients aged 80 years and older increased by 76 percent, and this new number is expected to increase by more than 50 percent by 2020. Current information about outcomes in octogenarians undergoing cancer operations is limited largely to case studies from tertiary care centers, which perform high volumes of these procedures and thus have superior outcomes. For lung, esophageal and pancreatic resection, single-center studies report operative mortality rates between 3 and 4 percent for the very elderly.

"Our study showed that there is a need to improve patient outcomes in the elderly nationwide," said lead investigator of the study Emily Finlayson, MD, MS, assistant professor of surgery, University of Michigan. "Furthermore, it provides a wake up call that the realistic risks and long-term benefits of major cancer operations differ for older patients when compared to their younger counterparts. This difference is essential to consider when surgeons and their older patients are making decisions about whether or not to have this type of surgery, particularly if the patient has other existing medical issues as this further affects the risk-benefit equation."

Researchers conducted a retrospective cohort study of patients undergoing major resections for lung, esophageal and pancreatic cancer using short-term data from the Nationwide Inpatient Sample (NIS) database to assess operative mortality and discharge in octogenarians relative to younger patients (aged 65 to 69 years). Long-term data from the Surveillance and End Results Medicare database was then used to measure late survival in the elderly.

We believe that our population-based study yields more realistic results because it is representative of patient data from 1,000 hospitals across the country, not just data from the top hospitals, added Dr. Finlayson.

According to the NIS database, between 1994 and 2003 an estimated 200,000 patients aged 65 years and older underwent resection for lung, esophageal or pancreatic cancer. For all three procedures, death during the surgical procedure among octogenarians was substantially higher than that of younger patients for all three cancers (esophagectomy, 19.9 percent versus 8.8 percent, p<0.0001; pancreatectomy, 15.5 percent versus 6.7 percent, p<0.0001; lung resection, 6.9 percent versus 3.7 percent, p<0.0001). Older age was strongly associated with decreased likelihood of being discharged to home after the operation. A large proportion of octogenarians were transferred to extended-care facilities after their operations, ranging from 24 percent after lung resection to 44 percent after esophagectomy. Five-year survival in octogenarians was low for all three cancers: 11 percent after pancreatectomy, 18 percent after esophagectomy and 31 percent after lung-cancer resection. Survival among octogenarians with two or more comorbidities was worse than those with fewer comorbidities.


'/>"/>

Contact: Sally Garneski
pressinquiry@facs.org
312-202-5409
Weber Shandwick Worldwide
Source:Eurekalert

Related medicine news :

1. Penn study finds pro-death proteins required to regulate healthy immune function
2. New study shows promise in reducing surgical risks associated with surgical bleeding
3. Study, meta-analysis examine factors associated with death from heatstroke
4. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
5. Study says COPD testing is not measuring up
6. Preclinical study suggests organ-transplant drug may aid in lupus fight
7. Ability to cope with stress can increase good cholesterol in older white men, study finds
8. High alcohol consumption increases stroke risk, Tulane study says
9. Mailman School of Public Health study examines link between racial discrimination and substance use
10. Pitt study finds inequality in tobacco advertising
11. Stanford study highlights cost-effective method of lowering heart disease risks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/27/2016)... ... May 27, 2016 , ... More than a third of ... not surprising that bariatric surgery has received increased attention in recent years, as an ... when it comes to weight loss, most people are familiar with the basic requirements ...
(Date:5/27/2016)... ... ... W.S. Badger Co. Inc ., the maker of certified organic and ... of the best small businesses for new dads by Fatherly, the digital lifestyle guide ... progressive benefits to new parents on the organization’s 2016 Best Places to Work ...
(Date:5/27/2016)... York, NY (PRWEB) , ... May 27, 2016 , ... ... factors of a stroke, which we as a society can control and change. , ... stroke occurs nearly every 40 seconds within the United States. Plus, with an estimated ...
(Date:5/27/2016)... ... 2016 , ... Beleza Medspa has initiated a new program to ... the first time that Coolsculpting is being used for for more than just cosmetic ... they meet the prescribed body-fat standard, measured by the circumference-based tape method. The ...
(Date:5/27/2016)... Wis. (PRWEB) , ... May 27, 2016 , ... ... $90,000 in scholarships to students studying complementary medicine. Allison Outerbridge is this year’s ... accepted her award on May 18 at the university’s Student Leadership Awards ceremony. ...
Breaking Medicine News(10 mins):
(Date:5/26/2016)... 26, 2016   Change Healthcare , ... network solutions and technology-enabled services designed to ... into a strategic channel partnership with SourceMed, ... solutions and revenue cycle management services that ... rehabilitation clinics to optimize revenue, operational efficiency ...
(Date:5/25/2016)... 2016 According to a new ... 2D, 4D), by Therapeutic Area (Oncology, Cosmeceutical/Plastic Surgery), by ... Device Manufacturers, Hospitals/ Clinics) - Forecast to 2021", published ... Market for the forecast period of 2016 to 2021. ... by 2021 from USD 117.3 Million in 2016, at ...
(Date:5/25/2016)... , May 25, 2016  Zymo Research ... for their new reference materials that help researchers ... sample collection to analyses. The rapid growth of ... for researchers to have standard methods to improve ... generated. Biases inherently exist at every step of ...
Breaking Medicine Technology: