Navigation Links
Study finds novel therapy that may prevent damage to the retina in diabetic eye diseases
Date:7/27/2012

Researchers at the University of Michigan Kellogg Eye Center have identified a compound that could interrupt the chain of events that cause damage to the retina in diabetic retinopathy. The finding is significant because it could lead to a novel therapy that targets two mechanisms at the root of the disease: inflammation and the weakening of the blood barrier that protects the retina.

To date, treatments for diabetic retinopathy, the leading cause of blindness among working-age Americans, have been aimed largely at one of those mechanisms.

In diabetic retinopathy, damage to the retina results, in part, from the activity of vascular endothelial growth factor (VEGF), a protein that weakens the protective blood-retinal barrier. Recent drugs targeting VEGF have exhibited good response for nearly half of the patients with diabetic retinopathy. But researchers believe that there is also an inflammatory component that may contribute to the disease process.

The study, published in the Biochemical Journal, June 2012 [epub ahead of print] identifies a specific protein common to both pathways as an important target in regulating the disease process in which blood vessels become leaky, and provides a drug that may be developed into a therapeutic intervention for patients in which anti-VEGF treatment alone is not sufficient.

"In diabetic retinopathy and a host of other retinal diseases, increases in VEGF and inflammatory factors some of the same factors that contribute to the response to an infection cause blood vessels in the eye to leak which, in turn, results in a buildup of fluid in the neural tissue of the retina," says David A. Antonetti, Ph.D., Professor, Department of Ophthalmology and Visual Sciences and Molecular and Integrative Physiology, who has also been awarded a Jules and Doris Stein Professorship from Research to Prevent Blindness. "This insidious form of modified inflammation can eventually lead to blindness." '/>"/>

Contact: Barbara Sefton
bwsefton@umich.edu
734-763-6967
University of Michigan Health System
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Weight Control Can Cut Womens Diabetes Risk, Study Shows
2. Study finds gaps in services for heterosexual men with HIV
3. Study: Group yoga improves motor function and balance long after stroke
4. HIV Undetectable in 2 Men After Bone Marrow Transplants: Study
5. Using Exhaust Fan on a Gas Stove Cuts Pollution: Study
6. MRSA cases in academic hospitals double in 5 years: study
7. Illegal Bath Salts Mimic Cocaine in the Brain: Study
8. Experimental Drug Suppresses Appetite in Mice: Study
9. NIH-funded study finds high HIV infection rates among gay and bisexual black men in the US
10. Untreated Heartburn May Raise Risk for Esophageal Cancer, Study Says
11. Cancer Drug May Flush Out Hidden HIV: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... in the April issue of Immunity , Kevin ... Medical Research, says it,s time to take a fresh ... sepsis, which kills millions worldwide every year, including ... released into the bloodstream to fight an injury or ... for maintaining good health without inflammation, wounds and ...
(Date:4/17/2014)... A Northwestern University synthetic biology team has created ... create programmable therapeutics that could travel the body ... disease. , Engineering cell-based, biological devices that monitor ... in clinical synthetic biology. However, no existing technology ... a patient,s physiological state and respond in a ...
(Date:4/17/2014)... Doctors who treat patients with a severe and ... an agonizing treatment decision. , The drug sirolimus ... relieve shortness of breath. But some patients eventually ... potentially fatal complications following transplantation. , "It,s a ... director of Loyola University Medical Center,s LAM Clinic ...
(Date:4/17/2014)... YORK, NY (April 16, 2014) The cause of ... a new study proposes that neurons may be mistaken ... immune system, similar to the way autoimmune diseases like ... the body,s cells. The study was published April 16, ... a new, and likely controversial, idea in Parkinson,s disease; ...
(Date:4/17/2014)... April 17, 2014 By discovering a new mechanism ... a stroke, researchers at UC Irvine and the Salk ... may limit or prevent stroke-induced brain damage. , A ... cause of death and primary reason for disability in ... a stroke and lets blood-borne material into the brain, ...
Breaking Medicine News(10 mins):Health News:Feinstein Institute researcher publishes new perspective on sepsis 2Health News:Building 'smart' cell-based therapies 2Health News:Patients with rare lung disease face agonizing treatment dilemma 2Health News:Patients with rare lung disease face agonizing treatment dilemma 3Health News:Is Parkinson's an autoimmune disease? 2Health News:Study IDs new cause of brain bleeding immediately after stroke 2
... An apple a day keeps the doctor away, yes; ... disease away as well//. Apple and apple juice were ... manner as medicines by researchers from the University of ... apple juice might increase the production in the brain ...
... Three years after the Centre for Science and Environment ... and a joint parliamentary committee endorsed it later// , ... again in 11 brands. ,Addressing a press conference ... by their pollution-monitoring laboratory has found pesticides in soft ...
... nutrition may be the best way to eat a lot during ... dietary details of about 7500, adults, researchers found that those who ... a larger quantity of food than those who consumed rich food. ... calorie count was much less than those who ate richer food. ...
... of people in UK expose themselves to the rays of the ... among cancer experts, who are rather troubled by this cream-free attitude.// ... and a record high temperature in July, it would indeed pay ... ,The trend is also because nearly 58% of the people do ...
... marijuana at the time of conception or in early ... to a new study in mice.// ,The author ... of pediatrics, cell and developmental biology and pharmacology at ... August issue of the Journal of Clinical Investigation. The ...
... of Tsunami 2004 is still fresh in the memory. There ... which ‘preparedness in adequate measure’ is considered extremely crucial.// It ... extended this sentiment in evolving suitable strategies against a potential ... German scientists will begin the exercise of delving into the ...
Cached Medicine News:Health News:Apple Juice May Keep Alzheimer's Away 2Health News:Marijuana Use Can Compromise Pregnancy 2
(Date:1/15/2014)... , Jan. 15, 2014 Reportlinker.com announces ... available in its catalogue: ... Drug Delivery Systems -- Focus on End ... STUDY OBJECTIVES A drug ...
(Date:1/15/2014)... 15, 2014  A novel wearable injector slightly larger than an ... patients to self-inject prescription drugs in the large doses required ... diseases, autoimmune deficiencies, and genetic disorders.  An ... by 2018, according to analysts.   Many of these drugs will ...
(Date:1/14/2014)... 14, 2014 InformEx, North America,s ... chemistry, will hold the 30 th edition of its ... Convention Center from January 21-24. (Logo: http://photos.prnewswire.com/prnh/20131028/NY05330LOGO-a ... pharmaceutical, fine chemical and specialty chemical companies will take part ...
Breaking Medicine Technology:Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 2Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 3Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 4Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 5Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 6Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 7Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 8Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 9Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 10Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 11Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 12Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 13Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 14Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 15Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 16Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 17Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 18Enable Injections Presents A New Class of Injectors for Drug Delivery at PEPTalk, Drug Delivery Partnership Meetings 2Media Advisory: InformEx 2014 Events & Speaker Lineup for 30th Edition Conference in Miami Beach 2
... NUREMBERG, Germany, October 13 The German ... Mobile C-arms Business,Development Strategy Leadership Award" from the independent ... successful growth strategy,of the technology leader in the area ... up of important new markets, as well as the,securing ...
... WALTHAM, Mass., Oct. 13 According to Millennium Research ... intelligence, sustained economic growth since 2003 in Brazil, Russia, ... health care expenditures with an astounding $500 billion spent ... to diagnostic imaging scanners. Findings from MRG,s newest series ...
Cached Medicine Technology:Award-Winning Medical Technology From Germany 2Award-Winning Medical Technology From Germany 3$500 Billion Health Care Spend Boosts BRIC Countries' Diagnostic Imaging Sales Despite Global Recession, According to Millennium Research Group 2$500 Billion Health Care Spend Boosts BRIC Countries' Diagnostic Imaging Sales Despite Global Recession, According to Millennium Research Group 3
... newest member of the Xpect family, Xpect C. ... B in one rapid test. The simple-to-perform test ... in 20 minutes. ,The Remel Xpect family of ... of rapid, direct specimen tests that combine exceptional ...
Compact tray features all components for urethral catheterization....
... the Integrated Cytometry Solution offers a ... coupled with complete LIS connectivity. By ... sample undergoes - and managing the ... it delivers a progressive automated system ...
Convective Air Warming Blankets...
Medicine Products: