Navigation Links
Study finds novel therapy that may prevent damage to the retina in diabetic eye diseases
Date:7/27/2012

Researchers at the University of Michigan Kellogg Eye Center have identified a compound that could interrupt the chain of events that cause damage to the retina in diabetic retinopathy. The finding is significant because it could lead to a novel therapy that targets two mechanisms at the root of the disease: inflammation and the weakening of the blood barrier that protects the retina.

To date, treatments for diabetic retinopathy, the leading cause of blindness among working-age Americans, have been aimed largely at one of those mechanisms.

In diabetic retinopathy, damage to the retina results, in part, from the activity of vascular endothelial growth factor (VEGF), a protein that weakens the protective blood-retinal barrier. Recent drugs targeting VEGF have exhibited good response for nearly half of the patients with diabetic retinopathy. But researchers believe that there is also an inflammatory component that may contribute to the disease process.

The study, published in the Biochemical Journal, June 2012 [epub ahead of print] identifies a specific protein common to both pathways as an important target in regulating the disease process in which blood vessels become leaky, and provides a drug that may be developed into a therapeutic intervention for patients in which anti-VEGF treatment alone is not sufficient.

"In diabetic retinopathy and a host of other retinal diseases, increases in VEGF and inflammatory factors some of the same factors that contribute to the response to an infection cause blood vessels in the eye to leak which, in turn, results in a buildup of fluid in the neural tissue of the retina," says David A. Antonetti, Ph.D., Professor, Department of Ophthalmology and Visual Sciences and Molecular and Integrative Physiology, who has also been awarded a Jules and Doris Stein Professorship from Research to Prevent Blindness. "This insidious form of modified inflammation can eventually lead to blindness." '/>"/>

Contact: Barbara Sefton
bwsefton@umich.edu
734-763-6967
University of Michigan Health System
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Weight Control Can Cut Womens Diabetes Risk, Study Shows
2. Study finds gaps in services for heterosexual men with HIV
3. Study: Group yoga improves motor function and balance long after stroke
4. HIV Undetectable in 2 Men After Bone Marrow Transplants: Study
5. Using Exhaust Fan on a Gas Stove Cuts Pollution: Study
6. MRSA cases in academic hospitals double in 5 years: study
7. Illegal Bath Salts Mimic Cocaine in the Brain: Study
8. Experimental Drug Suppresses Appetite in Mice: Study
9. NIH-funded study finds high HIV infection rates among gay and bisexual black men in the US
10. Untreated Heartburn May Raise Risk for Esophageal Cancer, Study Says
11. Cancer Drug May Flush Out Hidden HIV: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... the Fed reported an increase in industrial production ... 0.4% while manufacturing output progressed to 1.0%. , This ... February this year. Capacity use has increased by more than ... increase that could be attributed to the boost in vehicle ... a measure of slack across the industries. , Output in ...
(Date:8/29/2014)... Only a handful of CPR and basic life ... which are consistent with recent health guidelines, according ... Medicine Australasia , the journal for the Australasian ... recognition and treatment of sudden cardiac arrest are ... of Turkish emergency medicine specialists put together the ...
(Date:8/29/2014)... 2014 As a chiropractic physician and ... that there’s a direct connection between the condition of ... back. "Since conventional shoe inserts and orthotics weren’t satisfying ... my own," he said. , Customizable to a user’s ... for the foot in order to help prevent pain ...
(Date:8/29/2014)... FRIDAY, Aug. 29, 2014 (HealthDay News) -- Researchers have ... in their brains. Dyslexia -- the most commonly ... problems with reading and writing. Previous research showed ... but most of those studies focused only on a ... used functional MRI to analyze how multiple brain regions ...
(Date:8/29/2014)... Angeles (PRWEB) August 29, 2014 ... Radio Today at http://www.blogtalkradio.com/dr-carol-francis/2014/08/29/psychologist-dr-carol-francis-addressing-empty-nest-syndrome .     , Mothers ... years of money, marital bliss, prodding, laughing and ... of the house this week. Relief and ... of “now what.” Dr. Carol Francis ...
Breaking Medicine News(10 mins):Health News:LeaseQ Announces That Recent Industrial Production Report Spells Good Things For The Equipment Leasing Industry 2Health News:LeaseQ Announces That Recent Industrial Production Report Spells Good Things For The Equipment Leasing Industry 3Health News:Scientists Find Differences in Brains of Those With Dyslexia 2Health News:Psychologist Dr. Carol Francis Addressing Empty-Nest Syndrome on Talk Radio Today 2Health News:Psychologist Dr. Carol Francis Addressing Empty-Nest Syndrome on Talk Radio Today 3
... MPH, an endocrinologist at Nationwide Children,s Hospital, has developed ... text messages to remind adolescent diabetes patients about their ... Dr. Dyer found an increase in overall treatment adherence ... began developing this pilot study after realizing the potential ...
... Reporter , THURSDAY, July 29 (HealthDay News) -- Although ... and ward off osteoporosis, New Zealand researchers say the supplements ... small increase in the risk for heart attack among older ... researchers suggest that people get their required calcium, if possible, ...
... CD74 is a protein that is expressed in and ... lymphocytes and antigen presenting cells. This protein is known ... immune response. Additionally, Professor Shachar,s lab has previously shown ... of the immune system, and that its stimulation by ...
... important factor, influencing both morbidity and recovery after ... allow early intervention, which may prevent later complications. ... medical evaluations to identify significant weight loss over ... thickness, serum nutritional factor levels and functional measurements ...
... (HCC) is one of the most common cancers ... of the more difficult cancers to treat. It ... A number of dietary compounds possess anti-cancer properties. ... specific targets that control cell proliferation and apoptosis. ...
... clinical medicine are familiar with learning curves, and strategies ... on clinical care. Because similar learning curves have been ... University Medical Center studied the phenomenon in the data ... point to ways to improve the quality of future ...
Cached Medicine News:Health News:Pilot study supports adolescent diabetes patients through personalized text messages 2Health News:Calcium Supplements Linked to Boost in Heart Attack Risk 2Health News:Calcium Supplements Linked to Boost in Heart Attack Risk 3Health News:Calcium Supplements Linked to Boost in Heart Attack Risk 4Health News:How to detect malnutrition in patients effectively? 2Health News:Clinical trials can be improved by managing the learning curve 2Health News:Clinical trials can be improved by managing the learning curve 3
(Date:8/28/2014)... Aug. 28, 2014 /PRNewswire-iReach/ -- CountryFocus: Healthcare, Regulatory ... (Photo - http://photos.prnewswire.com/prnh/20140828/140879 ) ... Regulatory and Reimbursement Landscape Poland " an essential ... in the healthcare market and provides insights into ... Most importantly, the report provides valuable insights into ...
(Date:8/28/2014)... , Aug. 28, 2014  Decision Resources Group finds that ... at around $7.7 billion by 2023 in the ... Germany , Italy , ... and Japan . The biosimilar erosion ... be balanced out by the launch of Eli Lilly,s Cyramza, ...
(Date:8/28/2014)... , Aug. 28, 2014   Edison Nation ... announced a worldwide search for product ideas to ... population.  Promising ideas uncovered through the 6-month search ... medical device manufacturers and healthcare retailers with whom ... lives of individuals age 65 and older. ...
Breaking Medicine Technology:Poland & Turkey Pharmaceutical Market worth $15 billion & $21.5 billion Respectively by 2020 2Poland & Turkey Pharmaceutical Market worth $15 billion & $21.5 billion Respectively by 2020 3Poland & Turkey Pharmaceutical Market worth $15 billion & $21.5 billion Respectively by 2020 4Poland & Turkey Pharmaceutical Market worth $15 billion & $21.5 billion Respectively by 2020 5The Colorectal Cancer Market Will Remain Steady at $7.7 Billion by 2023, With Biosimilar Erosion Of Key Agents Being Balanced Out By the Launch Of Premium-Priced Therapies 2Edison Nation Medical Launches Open Innovation Search to Uncover Innovative Senior Care Products 2Edison Nation Medical Launches Open Innovation Search to Uncover Innovative Senior Care Products 3
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: