Navigation Links
Study finds new key to corneal transplant success
Date:7/1/2010

SAN FRANCISCO, CA Although it is already one of medicine's most successful transplant procedures, doctors continue to seek ways to improve corneal transplants. Now, for the first time, a team of German and British researchers have confirmed that failure and rejection of transplanted corneas are more likely in patients whose eyes exhibit abnormal vessel growth, called corneal neovascularization, prior to surgery. The meta-analysis report appears in July Ophthalmology, the journal of the American Academy of Ophthalmology. The findings also suggest a new treatment approach that could improve transplant success rates.

Claus Cursiefen, MD, and colleagues reviewed 19 studies involving nearly 24,500 corneal transplants (called "grafts"). The cornea is the eye's clear outer surface that provides much of the visual power.

"The presence of corneal neovascularization before surgery makes it about 30 percent more likely that the transplant will fail, and more than doubles the risk of graft rejection," said Dr. Cursiefen. "We also found that the risks of failure and rejection rise with the extent of vascularizationthe more extensive the corneal neovascularization, the higher the risks."

These findings suggest that patients who have corneal neovascularization might benefit from treatment before transplant surgery with growth-inhibiting drugs (antiangiogenics) such as bevacizumab or ranibizumab, or with another type of drug that works at the level of gene transcription to discourage vessel growth; one such drug, GS101, is now in clinical trials. This "preconditioning" approach is worthy of thorough testing and assessment, the researchers say.

"In the future, preconditioning a vascularized cornea before transplantation may be a useful strategy to promote survival of the graft," Dr. Cursiefen said.

More than 40,000 transplant surgeries are performed annually in the United States to restore vision in people whose corneas have
'/>"/>

Contact: Mary Wade
mwade@aao.org
415-447-0221
American Academy of Ophthalmology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Casual Sex Doesnt Cause Emotional Damage: Study
2. Study Finds Possible Explanation for the Link Between Infertility and Breast/Ovarian Cancer Risks
3. Screening for Spinal Muscular Atrophy Not Cost-Effective: Study
4. New study finds possible source of beta cell destruction that leads to Type 1 diabetes
5. New Study Demonstrates Novel Use of Metabolic Imaging to Locate Sperm in Infertile Men -- Non-Invasive Imaging Procedure May Replace Invasive Techniques such as Testicula
6. Risk of stroke lower for recent Ontario immigrants: study
7. Definitive study confirms chemo benefit in postmenopausal breast cancer
8. Experimental stem cell treatment arrests acute lung injury in mice, study shows
9. Violence is part of the job say nurses as study shows only 1 in 6 incidents are reported
10. Controversial Autism Study Retracted by Medical Journal
11. Study Reveals Impact Of Health Insurance On Hispanics' Attitudes Towards Healthcare Providers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... research team has been awarded a three-year $1.7 ... (NIH) to develop new imaging technologies and data ... how large networks of neurons in the brain ... help researchers identify the precise interactions between millions ... and speaking, and alterations in these interactions that ...
(Date:9/30/2014)... 2014 Elevate , the latest product ... in and out of the gym by providing natural ingredients ... attention of Shane Michaels, prompting an investigative review. , ... reason most people simply just don’t have the ability to ... at work, getting the motivation to finish a project, or ...
(Date:9/30/2014)... White Plains, NY (PRWEB) September 30, 2014 ... (HPCW) recently hosted its annual “In Celebration” gala, ... furthering the nonprofit’s mission of striving to provide ... individuals and families facing a serious or life-limiting ... Westchester Country Club in Rye, NY and recognized ...
(Date:9/30/2014)... 2014 Dr. Karl R.O.S. Johnson, DC, ... of care that is dramatically improving the health ... Chiropractic Neurology & Nutrition—applies a proprietary, multi-dimensional approach that ... addresses sources of inflammation, neurology of the joint and ... from the brain to the spine, to the legs, ...
(Date:9/30/2014)... WASHINGTON (Sept. 30, 2014) Levothyroxine is considered the ... and a new review of therapies for the condition ... not altered that assessment, say a team of investigators.,1Their ... journal Thyroid , finds insufficient consistent data exist ... whether generic, or sold under various trade names, such ...
Breaking Medicine News(10 mins):Health News:UMD receives inaugural BRAIN Initiative Award 2Health News:Elevate: Review Exposes Blue Star Nutraceutical’s Latest Supplement for Ultimate Brain Function, Focus, and Energy 2Health News:Hospice & Palliative Care of Westchester Honors Outstanding Individuals at Annual ‘In Celebration’ Gala 2Health News:Newly Developed Program Eases Chronic Knee Pain without Surgery and in as Little as Two Days 2Health News:Newly Developed Program Eases Chronic Knee Pain without Surgery and in as Little as Two Days 3Health News:New guidelines for treatment of hypothyroidism endorse current therapy 2
... Plans, Lists for Third ... Straight Year, FLINT, ... Medicare Advantage and Medicaid health,plans have been recognized by U.S. News & ... named among the top 50,Commercial plans and the top 25 plans for ...
... to add 300 jobs, PITTSBURGH, Oct. 26 ... has selected Highmark Medicare Services Inc. as the ... Part A,and Part B fee-for-service claims and other ... Columbia. Highmark Medicare Services will,process Medicare fee-for-services claims ...
... Aetna Claims at No Cost -, PARSIPPANY, N.J., ... company focused on providing innovative products for,electronic health care ... its relationship with Aetna to include a direct,connection for ... a leading,diversified health care benefits company with more then ...
... to help manage performance dashboards for Military ... Healthcare Facilities worldwide, ... Military Health System (MHS), awarded a four-year, $1.3,million contract extension ... will extend a previous contract,through 2011, for implementation of SciHealth,s ...
... 25, 2007 Shire plc (LSE: SHP, NASDAQ: ... announced that data from a 12-month study of ... Disorder (ADHD) patch, demonstrated that DAYTRANA provided significant ... aged 6 to 12 years. The study ...
... outcomes, researchers say , THURSDAY, Oct. 25 (HealthDay News) ... (ANP) can lessen cardiac injuries after heart attack and boost ... Japanese study in this week,s issue of The Lancet ... heart muscle (infarct) and lessened what,s known as "reperfusion injuries," ...
Cached Medicine News:Health News:Highmark Medicare Services Awarded New Contract from Centers for Medicare & Medicaid Services 2Health News:MD On-Line Expands Relationship with Aetna for Direct Claim Submission 2Health News:SciHealth Awarded Multi-year Contract with U.S. Department of Defense, Military Health System 2Health News:Long-term 12-month safety data on ADHD patch DAYTRANA 2
(Date:9/30/2014)... ATLANTA , Sept. 30, 2014  Georgia-Pacific ... systems, towels and tissue for a wide range ... success of its product lines in healthcare, including ... practices, Georgia-Pacific Professional is introducing its healthcare products ... "Georgia-Pacific Professional understands the importance of infection control ...
(Date:9/30/2014)... 30, 2014   Decision Resources Group finds ... anemic chronic kidney disease non-dialysis (CKD-ND) patients are ... medication. In addition, one-year persistency is similar between ... Other key findings from the report entitled ... Erythropoiesis Stimulating Agents in Late Stage Chronic Kidney ...
(Date:9/30/2014)... , Sept. 30, 2014   Acutus ... minimally invasive real-time 3D Cardiac Chamber Imaging and Dipole ... and / or sustain complex cardiac arrhythmias, including atrial ... to continue developing its imaging/mapping system as well as ... will allow Acutus Medical to complete work on the ...
Breaking Medicine Technology:Georgia-Pacific Professional Brings Its Success in Medical Solutions to the Dental Community 2Georgia-Pacific Professional Brings Its Success in Medical Solutions to the Dental Community 3Persistency is Low for Late-Stage Anemic CKD Non-Dialysis Patients Treated with Erythropoiesis-Stimulating Agents 2Persistency is Low for Late-Stage Anemic CKD Non-Dialysis Patients Treated with Erythropoiesis-Stimulating Agents 3Acutus Medical, Inc. Completes Additional $26.2M Series B Financing to Fund Portfolio Expansion 2Acutus Medical, Inc. Completes Additional $26.2M Series B Financing to Fund Portfolio Expansion 3
... NEW YORK, Oct. 7 Reportlinker.com announces that ... its catalogue: U.S. Venous Access ... This study covers U.S. markets for ... (PICCs), central venous catheters (CVCs), dialysis catheters, implantable ...
... Halozyme Therapeutics, Inc. (Nasdaq: HALO ), ... extracellular matrix, today announced that it will host a ... in New York. During the meeting, Halozyme,s management will ... business alliances with Roche and Baxter, and an update ...
Cached Medicine Technology:Reportlinker Adds U.S. Venous Access Catheter Market 2Reportlinker Adds U.S. Venous Access Catheter Market 3Reportlinker Adds U.S. Venous Access Catheter Market 4Halozyme Therapeutics to Host Analyst Meeting on October 14 in New York 2
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: