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Study finds narcolepsy cases in China peak in early spring
Date:8/21/2011

New research shows that the occurrence of narcolepsy in China is highly correlated to a seasonal pattern, with onset most frequent in April. A significant increase in narcolepsy cases was also observed following the 2009-2010 H1N1 pandemic, but the findings now available in Annals of Neurology, a journal of the American Neurological Association and the Child Neurology Society, report flu vaccination was unlikely the cause of the increase.

Narcolepsy is a chronic neurological disorder that is caused by a loss of hypocretina neurotransmitter in the brain that is responsible for communication of biological processes, such as sleep. When brain cells lose hypocretin there is an inability to control sleep-wake cycles. According to the National Institutes of Neurological Disorders and Stroke (NINDS) those with the disorder experience sudden bouts of sleep at any time, a sudden loss of voluntary muscle tone (cataplexy), vivid dreams or hallucinations, and short periods of total paralysis.

Medical evidence shows that narcolepsy-cataplexy affects less than 1% of the world population and NINDS estimates 1 in 3,000 Americans have this disorder. Following the 2009-2010 H1N1 pandemic, studies reported increased incidence in narcolepsy and increased risk of narcolepsy in patients receiving the Pandemrix vaccine. Other studies show that infection with streptococcus preceded the onset of narcolepsy in Caucasian patients, suggesting upper airway infections may trigger the disorder.

For the present study the research team, led by Dr. Fang Han from the Beijing University People's Hospital in China and Dr. Emmanuel Mignot with the Stanford Center for Sleep Sciences and Medicine in Palo Alto, California, conducted retrospective analysis of narcolepsy onset in patients diagnosed between 1998 and 2011 in Beijing. Data on the month and year of narcolepsy onset was collected from 629 patients (86% children) who were part of the Stanford-Beijing Unive
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Contact: Dawn Peters
healthnews@wiley.com
781-388-8408
Wiley-Blackwell
Source:Eurekalert

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