Navigation Links
Study finds narcolepsy cases in China peak in early spring
Date:8/21/2011

New research shows that the occurrence of narcolepsy in China is highly correlated to a seasonal pattern, with onset most frequent in April. A significant increase in narcolepsy cases was also observed following the 2009-2010 H1N1 pandemic, but the findings now available in Annals of Neurology, a journal of the American Neurological Association and the Child Neurology Society, report flu vaccination was unlikely the cause of the increase.

Narcolepsy is a chronic neurological disorder that is caused by a loss of hypocretina neurotransmitter in the brain that is responsible for communication of biological processes, such as sleep. When brain cells lose hypocretin there is an inability to control sleep-wake cycles. According to the National Institutes of Neurological Disorders and Stroke (NINDS) those with the disorder experience sudden bouts of sleep at any time, a sudden loss of voluntary muscle tone (cataplexy), vivid dreams or hallucinations, and short periods of total paralysis.

Medical evidence shows that narcolepsy-cataplexy affects less than 1% of the world population and NINDS estimates 1 in 3,000 Americans have this disorder. Following the 2009-2010 H1N1 pandemic, studies reported increased incidence in narcolepsy and increased risk of narcolepsy in patients receiving the Pandemrix vaccine. Other studies show that infection with streptococcus preceded the onset of narcolepsy in Caucasian patients, suggesting upper airway infections may trigger the disorder.

For the present study the research team, led by Dr. Fang Han from the Beijing University People's Hospital in China and Dr. Emmanuel Mignot with the Stanford Center for Sleep Sciences and Medicine in Palo Alto, California, conducted retrospective analysis of narcolepsy onset in patients diagnosed between 1998 and 2011 in Beijing. Data on the month and year of narcolepsy onset was collected from 629 patients (86% children) who were part of the Stanford-Beijing University Chinese narcolepsy study cohort. A vaccination history was provided by 182 participants who developed narcolepsy after October 2009.

"Our findings show a seasonal variation in narcolepsy onset in a Chinese population, occurring most frequently in late spring and early summer," said Dr. Han. Analysis revealed that onset of narcolepsy was least frequent in November and occurred most often in April, with close to a 7-fold increase from lowest point to peak time.

Researchers also studied year-to-year variations, identifying 173 cases of narcolepsy following the 2009-2010 H1N1 flu pandemic which represented a 3-fold increase in the disorder. "The increase in narcolepsy incidence was unlikely caused by increased vaccination as only 6% of study narcolepsy participants reported receiving a vaccination against H1N1," noted Dr. Mignot. A five to seven month delay between the seasonal peak in flu and peak in the onset of narcolepsy was also observed.

"These findings are reminiscent of the encephalitis lethargica epidemic that followed the great Spanish influenza pandemic of 1917-1918. Not only narcolepsy, but also psychosis and Parkinson's disease may follow winter infections, and further research is needed in the area of autoimmune diseases of the brain," Dr. Mignot concluded.


'/>"/>

Contact: Dawn Peters
healthnews@wiley.com
781-388-8408
Wiley-Blackwell
Source:Eurekalert

Related medicine news :

1. Despite Treatment, Employees with Depression Generate Higher Absentee Costs, According to Thomson Reuters Study
2. American Council on Exercise (ACE) Study Reveals Kettlebells Provide Powerful Workout in Short Amount of Time
3. TV drama can be more persuasive than news program, study finds
4. Study carried out into biological risks of eating reptiles
5. Neuroimaging study may pave way for effective Alzheimers treatments
6. Study finds racial gaps continue in heart disease awareness
7. Luth Researchs IndicatorEDG(TM) Study Finds Americans Hopes of Achieving Their Dreams Are Fading
8. First blinded study of venous insufficiency prevalence in MS shows promising results
9. Soothing infants with food focus of childhood obesity study
10. People with anxiety disorder less able to regulate response to negative emotions, study shows
11. American Heart Association Rapid Access Journal Report: Study Finds Racial Gaps Continue in Heart Disease Awareness, Low Knowledge of Heart Attack Warning Signs Among Women
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/24/2017)... ... August 24, 2017 , ... DrinkingTutors.com, a startup focused on ... tutorials, or ‘drinktorials,’ are mailed directly to teenagers’ homes every week. , ... their teenagers avoid the serious risks associated with binge drinking in high school, ...
(Date:8/23/2017)... ... ... Drs. Steven White and Brad Haines are pleased to announce an exclusive ... offer, valued at more than $300 per year, new patients can enjoy a lifetime ... a complimentary professional whitening procedure. , Stained or yellowed tooth enamel is common ...
(Date:8/23/2017)... , ... August 23, 2017 , ... Nightingale College continues ... Give Back Day is a time Nightingale College dedicates to serving and volunteering for ... thrive on donations and volunteers or those that need a little extra help. ...
(Date:8/23/2017)... (PRWEB) , ... August 23, 2017 , ... ... vans, announced today that has been named to the 2017 Inc. 500|5000, an ... based on a three-year growth rate of 139 percent, marking the twelfth year ...
(Date:8/23/2017)... ... August 23, 2017 , ... ... (SNAC) is holding an inaugural State of the Science Symposium in partnership ... Wednesday, Sept. 20, 2017. , This symposium provides a forum for global leaders ...
Breaking Medicine News(10 mins):
(Date:8/7/2017)... (NYSE: DPLO), the nation,s largest independent specialty pharmacy, announced financial ... unless otherwise noted, are to the quarter ended June 30, ... 2017 Highlights include: Revenue of $1,126 ... Total prescriptions dispensed of 220,000, compared to 241,000 ... Gross profit per prescription dispensed of $371, ...
(Date:8/4/2017)... , Aug. 4, 2017 The search ... shortly after a physician/patient consult has long been the ... was a notable focus of the largest meeting of ... according to healthcare market research firm Kalorama Information.  The ... testing (POCT) offerings or related supplies and software were ...
(Date:8/3/2017)... Aug. 3, 2017  Opioid addiction and other drugs ... healthcare costs and threatening outcomes, were problems taken on ... IVD industry that support them, met this week. This ... said that drugs of abuse, procalcitonin and acute kidney ... the organization,s 69th meeting in San Diego, ...
Breaking Medicine Technology: