Navigation Links
Study finds key protein controls T-cell proliferation
Date:5/4/2010

New research has identified that a key protein called PEA-15 stops T-cell proliferation by blocking the cell's ability to reproduce. The control of T-cell proliferation is essential in preventing certain blood cancers and autoimmune diseases, as well as the orchestration of the immune response to infection. Findings of the study are reported in a recent online issue of The FASEB Journal, a publication of The Federation of American Societies for Experimental Biology.

A team of researchers from the University of Hawai'i Cancer Research Center, Rutgers University and Washington University in St. Louis examined the normal function of PEA-15, which acts as a tumor suppressor in some cancers including brain, ovarian and breast cancers. They found that PEA-15 normally controls lymphocyte (white blood cell) proliferation.

To determine the normal role of this protein, investigators examined mice lacking PEA-15. They found that those without the protein had both spatial learning disabilities and a pronounced increase in lymphocyte (white blood cell) proliferation. Upon closer inspection, they further found that loss of PEA-15 particularly affected a group of lymphocytes called T-cells. T-cells are involved in killing invading pathogens as well as stimulating more long-term immunity. The PEA-15 protein works by acting as a brake on a group of proteins that activate cell cycling and proliferation when they recognize a signal from an invading organism. Lymphocytes without PEA-15 continue proliferating beyond normal response levels as if they lack the "brakes" to stop.

"Understanding how T-cell expansion is controlled at the molecular level should lead to new methods to control the immune response during infection as well as perhaps helping the development of novel ways to utilize these cells to attack tumors," said Joe Ramos, Ph.D. principal investigator and assistant professor in natural products and cancer biology at the Universi
'/>"/>

Contact: Kellie Tormey
ktormey@crch.hawaii.edu
808-564-5814
University of Hawaii at Manoa
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Pay-for-performance programs may worsen medical disparities, study finds
2. Phase II study of an oral therapy for Gaucher disease yields positive results
3. Most common cancers in the world decreasing in Alberta: Study
4. For Younger Women, Mammograms Not Too Effective: Study
5. Prostate Cancer Test a Flop in Study
6. Study Published in Alzheimer's & Dementia: The Journal of the Alzheimer's Association Shows Algal DHA Improved Memory and Learning in Healthy Adults Age 55 and Older
7. Study evaluates importance of timeliness of care in breast cancer diagnosis and treatment
8. Male obesity linked to low testosterone levels, study shows
9. My kid wouldnt do that -- study shows parents difficulty with teen sexuality
10. Study shows for first time decrease in mortality associated with physician order entry system
11. Federal Agencies to Study Causes of Firefighters' Cancers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... Volunteers from Scientology Churches and Missions are ... education lectures, forums and conferences, information stands, sports events, ... world. , Drug abuse is an international epidemic. According ... of alcohol and illicit drugs costs more than $425 ... and healthcare. , In the face of statistics ...
(Date:7/11/2014)... 11, 2014 The report, “Specialty ... Applications & Geography - 2018,” defines and segments ... with an analysis and forecast of the volumes ... fibers (Para aramids, meta aramids, UHMW Polyethylene, carbon ... PPS fiber, PBI fiber, PBO fiber, and liquid ...
(Date:7/11/2014)... 11, 2014 Utilizing the Keller Funnel, ... William Koenig, has topped a record number of complication-free ... performed over 400 successful procedures without the occurrence of ... well known across the country for his expertise with ... has long been the foundation for numerous studies and ...
(Date:7/11/2014)... 2014 (HealthDay News) -- Children who have emergency ... complications and potentially even death than those who ... However, the Johns Hopkins researchers noted that ... researchers analyzed data on nearly 440,000 simple emergency ... over a 22-year period. The surgeries are ...
(Date:7/11/2014)... The report “Probiotics Market by Products (Functional ... (Regular, Therapeutic, Preventive Health Care) & Ingredients (Lactobacilli, ... 2019 ” defines and segments the global probiotics ... market value of probiotic products and ingredients. The ... for the global market with an analysis of ...
Breaking Medicine News(10 mins):Health News:Scientologists Taking Action against Drug Abuse 2Health News:Scientologists Taking Action against Drug Abuse 3Health News:Specialty Synthetic Fibers & Glass Fiber Market Poised to Reach $20.1 Billion at a CAGR of 5.2% by 2018 – Report by MarketsandMarkets 2Health News:Specialty Synthetic Fibers & Glass Fiber Market Poised to Reach $20.1 Billion at a CAGR of 5.2% by 2018 – Report by MarketsandMarkets 3Health News:Specialty Synthetic Fibers & Glass Fiber Market Poised to Reach $20.1 Billion at a CAGR of 5.2% by 2018 – Report by MarketsandMarkets 4Health News:Rochester Surgeon Hits Milestone with Keller Funnel 2Health News:Emergency Surgeries on Weekends Riskier for Kids: Study 2Health News:Probiotic Ingredient Market worth $1,732.8 Million by 2019 - A Report by MarketsandMarkets 2Health News:Probiotic Ingredient Market worth $1,732.8 Million by 2019 - A Report by MarketsandMarkets 3Health News:Probiotic Ingredient Market worth $1,732.8 Million by 2019 - A Report by MarketsandMarkets 4Health News:Probiotic Ingredient Market worth $1,732.8 Million by 2019 - A Report by MarketsandMarkets 5
... experiences on anti-aging and ... personal beauty, ... public launch of the first consumer website dedicated,to consumer reviews and ... engage in an,open and honest conversation about important decisions that affect ...
... 11:00AM Adults with Attention Deficit Hyperactivity ... Extended-release Tablets showed significant improvements in ADHD symptom ... study results presented today at a major psychiatric ... adolescents with ADHD is clearly established but relatively ...
... Mid-Sized Companies Control Health Care Costs, DALLAS, ... Kenneth H. Cooper, M.D., M.P.H., Cooper Aerobics Enterprises,Inc., ... 37-year,history. Cooper Aerobics Enterprises purchased Health At Work, ... a new division, Cooper Benefits,LLC. Cooper Benefits ...
... have been found in related literature. One extremely rare ... of the World Journal of Gastroenterology because of its ... and sex factors, clinical and histopathological findings, diagnostic methods ... available literature. , The article reported one patient ...
... Ala. University of Alabama at Birmingham (UAB) researchers ... progression and switches on front-to-back body patterning in tadpoles. ... in understanding the complex DNA and cell interplay that ... and other diseases. , The UAB team focused on ...
... AMCS ),announces the following Webcast: (Logo: http://www.newscom.com/cgi-bin/prnh/20060202/AMICASLOGO ... 1, 2007 @ 8:30 AM ET, Where: http://www.videonewswire.com/event.asp?id=43463 ... on to the web at the address ... Inc, 617-779-7892. If you are unable to participate during the ...
Cached Medicine News:Health News:Consumers Open Up on RealSelf.com About 'Getting Work Done' 2Health News:Consumers Open Up on RealSelf.com About 'Getting Work Done' 3Health News:New study of Concerta showed significant improvement of ADHD symptom management in adults 2Health News:An Industry First: New Cooper Health Company Makes Group Employee Benefits Consulting and Wellness Program Design a Package Deal 2Health News:An Industry First: New Cooper Health Company Makes Group Employee Benefits Consulting and Wellness Program Design a Package Deal 3Health News:An Industry First: New Cooper Health Company Makes Group Employee Benefits Consulting and Wellness Program Design a Package Deal 4Health News:The largest colonic lipoma to date 2Health News:Cell pathway, disease linked to histone action 2
(Date:7/10/2014)... , July 10, 2014  The U.S. Department of ... grant to University Hospitals (UH) Case Medical Center Seidman ... national model aimed at improving care for patients with ... the project will test a unique model developed at ... late-stage disease, significant comorbidities, or demonstrated need for high ...
(Date:7/10/2014)... DIEGO , July 10, 2014  RESMED INC. (NYSE: ... its fourth quarter and fiscal year ended June 30, 2014 ... Stock Exchange market close. A press release with ResMed,s results ... the company will host a webcast to discuss operating results ... to begin at 1:30 p.m. US Pacific Time and the ...
(Date:7/10/2014)... LAVAL, Quebec , July 10, 2014  Valeant ... TSX: VRX) today announced it has completed the sale ... Sculptra, and Dysport owned or held by Valeant for ... agreement with Nestle S.A, which recently completed its acquisition ... complete the divestiture of our products to a company ...
Breaking Medicine Technology:University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 2University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 3University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 4ResMed To Announce Fourth Quarter And Fiscal Year-End 2014 Results 2
... 2, 2011 ViroPharma Incorporated (Nasdaq: VPHM ) ... officer of ViroPharma, will present at the Jefferies 2011 Global ... 2011.  The conference is being held in New York City. ... through www.viropharma.com and available for a period of ...
... be presented in a poster at the 2011 Annual Meeting ... in Chicago, Illinois June 3-7 by researchers from The University ... that a laboratory test developed by Biocept, Inc. for the ... Disseminated Tumor Cells (DTCs) can provide potentially valuable information to ...
Cached Medicine Technology:MD Anderson and Biocept Scientists to Present Poster at ASCO on Disseminated Tumor Cells (DTCs) in Bone Marrow and Circulating Tumor Cells (CTCs) in Blood in Early Stage Breast Cancer Patients 2MD Anderson and Biocept Scientists to Present Poster at ASCO on Disseminated Tumor Cells (DTCs) in Bone Marrow and Circulating Tumor Cells (CTCs) in Blood in Early Stage Breast Cancer Patients 3
... polymerase chain reaction (PCR) to amplify and ... first to fully automate and integrate all ... sample preparation, DNA amplification and detection. Designed ... PCR test results from a raw sample ...
... For use as a non-reactive quality assurance reagent ... Toxoplasma gondii (TOXO IgG and TOXO IgM), IgG ... and rubella IgM), IgG and IgM antibodies to ... IgM antibodies to herpes simplex virus types 1 ...
... a fully automated system with,a disposable ... new refractive procedure known,as Epi-Lasik. The ... epithelium from the,Bowmans membrane leaving a ... the structural integrity,of the stroma and ...
... is a surgical/ mechanical device designed to ... the cornea above Bowman's layer. The Centurion ... used during LASEK to delaminate the epithelium. ... providing a 'minimal-touch' surgical approach, the SES ...
Medicine Products: