Navigation Links
Study finds key link responsible for colon cancer initiation and metastasis
Date:11/11/2013

slow progression, but a very poor response to treatment and a high mortality rate.

Researchers have known that the broad mechanisms of cancer involve an interplay with the immune system response that includes: recruiting immune cells that influence the tumor microenvironment, escaping from host immunosurveillance and suppression, shifting of the host immune response, and tumor-associated angiogenesis to establish the blood supply.

For the study, the research team first "knocked-out" or removed the CXCR2 gene in mice, and found that the signs typically associated with inflammation were prevented. Furthermore, they demonstrated that CXCR2 dramatically suppressed colonic inflammation and the colitis associated tumor formation, growth and progression in mice.

CXCR2 decorates the outer part of immune cells called myeloid-derived suppressor cells, or MDSCs, that work to block the immune response of killer CD8+ T cells. In the knockout mice, without CXCR2 present, the MDSC cells could no longer migrate from the circulatory system to the colon, dodge the killer CD8+ T cell immune response, and feed the blood supply of the tumor environment. Furthermore, when they transplanted normal MDSC cells (with normal CXCR2) into the knockout mice, tumor formation was restored.

"These results provide the first genetic evidence that CXCR2 is required for recruitment of MDSCs into inflamed colonic mucosa and colitis-associated tumors," said DuBois.

For DuBois, who has devoted his career to unraveling the inflammatory circuitry responsible for colon cancer, the results help connect the dots between the immune system, inflammation and tumor formation and metastasis.

DuBois' team was the first to show that colorectal tumors contained high levels of the enzyme cyclo-oxygenase-2 (COX-2), a key step in the production of pro-inflammatory mediators such as prostaglandin E2 (PGE2). PGE2 triggers production of a CXCR2 molecule that fits
'/>"/>

Contact: Joe Caspermeyer
joseph.caspermeyer@asu.edu
480-258-8972
Arizona State University
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Princeton study: Military children and their families remain an invisible subculture
2. Hope for transplant patients as study finds key to organ scarring
3. Searchen Releases Statement on Celebrity and Athletic Endorsement Study
4. Investigational Drug Effective in Treating Iron Deficiency in Chronic Kidney Disease Patients on Dialysis: Study
5. Journal of Traumatic Stress Study Analyzes Psychological Effects of Marathon Bombing on Boston-Area Veterans with Post-Traumatic Stress Disorder (PTSD)
6. In animal study, cold turkey withdrawal from drugs triggers mental decline
7. TGen-led study reveals TWEAK-Fn14 as key drug target
8. Study using stem cells to improve organ transplantation to receive $12 million
9. FDA awards $2.25M grant to study immunosuppresive drug in high-risk patients
10. Study finds that Americans want doctors guidance on genetic test results
11. New study assesses injuries seen in the emergency department to children of teenage parents
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study finds key link responsible for colon cancer initiation and metastasis
(Date:12/25/2014)... THURSDAY, Dec. 25, 2014 (HealthDay News) -- Overeating is common ... you eat in moderation, an expert says. "Don,t arrive ... up calories if you know you,ll be attending a party, ... Jill Ashbey-Pejoves, lead dietitian at Northern Westchester Hospital in Mount ... better to eat healthy during the day and even to ...
(Date:12/25/2014)... (PRWEB) December 25, 2014 “ SmileStix ” ... which features the latest and coolest mobile applications on the ... expert and host of NewsWatch, conducted the app review and ... to create personal stickers. , The old saying goes, “A ... lot of words that can describe a single image, because ...
(Date:12/24/2014)... AlignLife of Wauwatosa loves helping those ... During the holiday season, AlignLife looks forward to their annual ... Dr. Sara Mahalko-Leonhardt, owner of AlignLife. "It brings our patients ... we are able to give kids toys for Christmas who ... the generosity of our patients." , The 70 toys were ...
(Date:12/24/2014)... December 24, 2014 Risperdal lawsuit ( ... mass tort litigation currently underway in Pennsylvania’s Philadelphia Court ... of December 24, 2014, court documents indicate that 1,183 ... of individuals who developed gynecomastia (male breast growth) and ... the Court indicates that this represents an increase of ...
(Date:12/24/2014)... December 25, 2014 Today, Yunx.co.uk, a ... evening dresses and other special occasion outfits, unveils ... models are offered at discounted prices, up to 80% ... young ladies with their fashionable designs, gorgeous looks and ... exception. The business is devoted to designing and offering ...
Breaking Medicine News(10 mins):Health News:An Application to Create Custom Stickers was Featured on NewsWatch Television on December 19, 2014 2Health News:AlignLife of Wauwatosa Brings Joy to Less Fortunate Families 2Health News:Risperdal Lawsuits Continue to Climb, as Claims in Pennsylvania Litigation Exceed 1,180 Filings, Bernstein Liebhard LLP Reports 2Health News:Risperdal Lawsuits Continue to Climb, as Claims in Pennsylvania Litigation Exceed 1,180 Filings, Bernstein Liebhard LLP Reports 3Health News:Risperdal Lawsuits Continue to Climb, as Claims in Pennsylvania Litigation Exceed 1,180 Filings, Bernstein Liebhard LLP Reports 4Health News:Yunx.co.uk Unveils 65 New Bridesmaid Dresses for the UK market 2
... radar of the immune system is by using IDO, an ... powerful regulatory T cells that turn down the immune response, ... barrier of regulatory T cells, or Tregs, but how ... David Munn, pediatric hematologist/oncologist at the Medical College of Georgia ...
... discovered a new protein that may offer fresh insights into ... defined a second prion protein called Shadoo, that exists in ... Professor David Westaway, director of the Centre for Prions and ... decades we believed PrP was a unique nerve protein that ...
... University of Sheffield in the UK and Leibniz Institute for ... that female hyenas avoid inbreeding with their male relatives by ... , Animals generally avoid inbreeding because it is genetically ... home or, like humans, by learning who their relatives are ...
... exposed to higher levels of air pollution show marked ... short-term breathing problems, according to researchers in Mexico. , ... in children with long-term exposure to air pollutants, wrote ... "In addition to the important impact of lung health, ...
... study to use brain imaging to look at the ... depression, researchers at the University of Wisconsin-Madison have found ... differently than those of healthy people when trying to ... Health Organization, clinical depression is one of the leading ...
... infection, use of the HPV-16/18 vaccine will not accelerate reduction ... the infection, according to a study in the August 15 ... HPV infection and the development of cervical precancers and cancer. ... the virus in women already infected, according to background information ...
Cached Medicine News:Health News:Tumors use enzyme to recruit regulatory T-cells and suppress immune response 2Health News:Tumors use enzyme to recruit regulatory T-cells and suppress immune response 3Health News:Tumors use enzyme to recruit regulatory T-cells and suppress immune response 4Health News:New prion protein discovered by Canadian scientists may offer insight into mad cow disease 2Health News:Females avoid incest by causing male relatives to leave home 2Health News:High pollution linked to poor lung function growth in children in Mexico City 2Health News:Clinical depression linked to abnormal emotional brain circuits 2Health News:Clinical depression linked to abnormal emotional brain circuits 3Health News:HPV vaccine does not appear to be effective for treating pre-existing HPV infection 2Health News:HPV vaccine does not appear to be effective for treating pre-existing HPV infection 3
(Date:12/24/2014)... SCHOFIELD, Wis. , Dec. 23, 2014 ... and marketer of over-the-counter (OTC) medicinal and healthcare products, ... production of MigraPure® H, a hemp-based, advanced headache relief ... marijuana dispensaries in Colorado , ... . With the MigraPure H Advanced ...
(Date:12/24/2014)... LEXINGTON, Mass. , Dec. 23, 2014 /PRNewswire/ ... GEVA ), a biopharmaceutical company developing therapeutic products ... European Medicines Agency (EMA) of the Marketing Authorization ... The EMA recently granted the company,s request for ... the EMA,s regulatory review time.   ...
(Date:12/24/2014)... Calif. , Dec. 23, 2014 In response ... Doctors, Association of Sierra Leone , Direct ... Leone for the treatment of local health workers ... While a new dedicated Ebola care center was constructed for ... the facility is not available for local Sierra Leonean health ...
Breaking Medicine Technology:PuraMed BioScience Nears Final Stages Needed for Distribution of MigraPure H 2PuraMed BioScience Nears Final Stages Needed for Distribution of MigraPure H 3Synageva BioPharma Announces Sebelipase Alfa Marketing Authorization Application Validated By The EMA 2Synageva BioPharma Announces Sebelipase Alfa Marketing Authorization Application Validated By The EMA 3First Ebola Treatment Unit for Local Health Workers Arrives in Sierra Leone 2
... 2011 Aoxing Pharmaceutical (NYSE Amex: ... focusing on research, development, manufacturing and distribution of ... subsidiary in China, Hebei Aoxing Pharmaceutical Group Company, ... Intellectual Property Office of The People,s Republic of ...
... 2011 IRIDEX Corporation (Nasdaq: IRIX ) ... had issued to IRIDEX a patent applying to a ... ophthalmic surgical procedures. The patent, No. 7,909,816 and titled ... consumable medical devices already in the IRIDEX product line ...
Cached Medicine Technology:Aoxing Pharmaceutical Company Announces Issuance of Chinese Patent for Naloxone Sublingual Film 2Aoxing Pharmaceutical Company Announces Issuance of Chinese Patent for Naloxone Sublingual Film 3IRIDEX Granted U.S. Patent for Stepped Angled Laser Handpieces Used in Eye Surgery 2IRIDEX Granted U.S. Patent for Stepped Angled Laser Handpieces Used in Eye Surgery 3
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: