Navigation Links
Study finds iron levels not predictive of survival for form of blood cancer
Date:5/11/2009

Rochester, Minn. - May 11, 2009 Iron chelating drugs have been heavily promoted for use in patients with primary myelofibrosis (PMF), a form of blood cancer often treated with blood transfusion. These drugs, however, which withhold available iron in the body, are highly expensive and potentially toxic. A new study published in American Journal of Hematology finds that their increased use has been propagated by non-evidence based, and often industry-sponsored, statements and opinions, rather than original research, and that the conclusions are often based on poor data.

The study shows that the degree of anemia in patients suffering from PMF, age and need for red blood cell transfusion at diagnosis were stronger predictors for patient survival than serum ferritin level (a protein that stores iron), which is often used as a proxy for iron overload in the blood.

"Although iron chelation therapy in PMF would probably lower serum ferritin level in such patients, its value in terms of meaningful health outcomes remains dubious," says Dr. Ayalew Tefferi of the Mayo Clinic, principle author of the study.

In a related editorial in the journal, Dr. Thomas G. DeLoughery of Oregon Health & Science University states that "hematologists are under increasing pressure to prescribe iron chelation for seemingly any patient being transfused. However, there is no evidence that iron overload affects survival or morbidity."

The findings should impact clinical practice by discouraging the indiscriminate use of an expensive, potentially toxic and unproven therapy. The future challenge in treating myelofibrosis is to avoid transfusions by better therapies to reverse the stem cell defect. "Unfortunately, the recent focus on iron overload as a priority and not the stem cell defect is leading to a misallocation of resources on both the patient and practitioner's part," says DeLoughery.


'/>"/>

Contact: Sean Wagner
medicalnews@bos.blackwellpublishing.net
781-388-8550
Wiley-Blackwell
Source:Eurekalert

Page: 1

Related medicine news :

1. Penn study finds pro-death proteins required to regulate healthy immune function
2. New study shows promise in reducing surgical risks associated with surgical bleeding
3. Study, meta-analysis examine factors associated with death from heatstroke
4. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
5. Study says COPD testing is not measuring up
6. Preclinical study suggests organ-transplant drug may aid in lupus fight
7. Ability to cope with stress can increase good cholesterol in older white men, study finds
8. High alcohol consumption increases stroke risk, Tulane study says
9. Mailman School of Public Health study examines link between racial discrimination and substance use
10. Pitt study finds inequality in tobacco advertising
11. Stanford study highlights cost-effective method of lowering heart disease risks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... ... December 02, 2016 , ... ... launch of its 60-day free trial program for all of the company’s desktop ... offer a truly hassle free experience. , FlexiSpot’s unique desktop risers use an ...
(Date:12/2/2016)... ... ... The annual time frame to change Medicare health and prescription drug coverage, known ... Medicare beneficiaries who are looking to switch from their current plan to a Medicare ... during this period order for their new policy to go into effect in 2017. ...
(Date:12/2/2016)... ... December 02, 2016 , ... With the number of pain management programs available ... must find the one that works for them. When an inventor from Suisun City, ... worked and decided to share it with others. , He developed a prototype for ...
(Date:12/2/2016)... ... December 02, 2016 , ... Dr. Raffi Hovsepian, a leading ... the 2016 “Guide to America’s Top Plastic Surgeons” for seven consecutive years. The ... education, experience, and professional associations. , One the most frequently honored surgeons ...
(Date:12/2/2016)... ... December 02, 2016 , ... Mediaplanet is proud to announce ... covers the innovative treatments, therapeutic technologies, and revolutionized nutrition that are helping patients ... life 6 years in the last 3 decades,” says Dr. Valentine Fuster, a ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... MONMOUTH JUNCTION, N.J. , Dec. 2, 2016 /PRNewswire/ ... critical care immunotherapy leader commercializing its European Union approved ... in critically-ill and cardiac surgery patients worldwide, announced that ... present at the 9th Annual LD Micro Main ... 8 th , 2016 at the Luxe Sunset Boulevard ...
(Date:12/2/2016)... LYME, Conn. , Dec. 1, 2016  Today, ... has announced the honor of being selected as winners ... include: Simpson Healthcare Executives Website at the PLATINUM level, ... Conversations Training Module at the GOLD Level, and our ... At Simpson Healthcare Executives, we are excited ...
(Date:12/2/2016)... YORK , December 2, 2016 ... of its past losses following Trump,s victory early in ... potential, and fund managers are now predicting an uptick ... at four equities to see how they have fared ... CLDX ), Amicus Therapeutics Inc. (NASDAQ: ...
Breaking Medicine Technology: