Navigation Links
Study finds high CD4 cell counts associated with reduced risk of ischemic stroke for those with HIV
Date:6/24/2014

OAKLAND, Calif., June 24, 2014 A 15-year study found that HIV-positive individuals had a 40 percent increased risk of ischemic stroke, however stroke rates were nearly the same for HIV-positive individuals with high CD4 cell counts as for HIV-negative subjects.

The study, published recently in AIDS, the official journal of the International AIDS Society, covered the years 1996 through 2011 and included nearly 25,000 HIV-positive individuals.

Ischemic stroke is caused by plaque build-up in blood vessels, which can lead to constriction or actual obstruction of blood and oxygen flow to the brain. A CD4 cell count below 500 is considered a sign of a weakened immune system as it indicates lower numbers of white blood cells that fight infections and inflammation.

"Recent CD4 cell count was the strongest HIV-specific risk factor, suggesting an effect of current immunodeficiency on ischemic stroke risk," said senior author Michael J. Silverberg, PhD, MPH, an investigator with the Kaiser Permanente Division of Research in Oakland, California. "Notably, HIV-positive individuals with recent CD4 cell counts of 500 or more had no excess risk of ischemic stroke compared with HIV-negative individuals."

If the association between immunodeficiency on ischemic stroke risk is causal, the researchers concluded, early and consistent treatment with antiretroviral therapy to maintain immune function, combined with mitigation of stroke risk factors, may result in a similar risk of ischemic stroke among HIV-positive individuals compared with the general population.

"Our results suggest that maintenance of immune function may protect against ischemic stroke," said lead author Julia L. Marcus, PhD, MPH of the Division of Research. "Given recent calls to reduce or abandon CD4 monitoring among HIV-positive individuals with viral suppression, our data suggest that the CD4 cell count may be useful beyond its role in HIV disease monitoring."

The researchers found that, while ischemic stroke rates were higher over the entire study period, rates among HIV-positive individuals converged with rates for demographically-similar HIV-negative individuals by 2010-2011. A similar improved trend in risk of heart attack was observed previously in this same study cohort.

"As awareness of cardiovascular complications associated with antiretroviral therapy has increased, improved risk-factor management among HIV-positive individuals may have contributed to a decreasing risk over time," said co-author Daniel B. Klein, MD, chief of infectious diseases for Kaiser Permanente San Leandro. "It may also be that stroke risk has been mitigated by the earlier and wider use of antiretroviral therapy regimens with less cardiovascular risk."


'/>"/>

Contact: Samantha Purzak
spurzak@golinharris.com
202-585-2603
Kaiser Permanente
Source:Eurekalert

Related medicine news :

1. UCI study finds that learning by repetition impairs recall of details
2. For gastric bypass patients, percent of weight loss differs by race/ethnicity, study finds
3. New study offers potential avenues for treatment of deadly nasopharyngeal cancer
4. Long-term care must be improved to aid rising numbers with dementia, study finds
5. The ICEMAN study -- How keeping cool could spur metabolic benefits
6. New study explains how organs coordinate their development with the whole body
7. Study offers evidence that sunscreen use in childhood prevents melanoma in adults
8. Penn study reveals a common genetic link in fatal autoimmune skin disease
9. Pharmacy study expects to lower hospital readmissions
10. Study finds difference in way bipolar disorder affects brains of children versus adults
11. Proposed childrens study needs refinement, report finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... , ... March 28, 2017 , ... ... is the first technology to directly address the resolution to globally reduce the ... is a patented compound of FDA and TTB approved ingredients that when infused ...
(Date:3/28/2017)... ... 29, 2017 , ... The Thyroid Secret is a specialized ... The program was recently launched on March 1, and Dr. Wentz discussed varied ... , Dr. Izabella Wentz is a licensed pharmacist and a foremost thyroid specialist. ...
(Date:3/28/2017)... ... March 28, 2017 , ... ... dedicated to advancing the science and clinical practice of radiosurgery, announced today ... Registry, a multi-institutional, observational registry established to standardize data collection from patients ...
(Date:3/28/2017)... DC (PRWEB) , ... March 28, 2017 , ... WHO: ... Dr. Toni Bark , WHAT: , Medical doctors and PhD scientists will speak to ... written to President Trump in support of an independent vaccine safety commission. , ...
(Date:3/28/2017)... ... March 28, 2017 , ... ... Paul Yost, will begin serving as new board chair for Orange County health ... will serve the remainder of soon-to-be former chair Mark Refowitz’s term, which runs ...
Breaking Medicine News(10 mins):
(Date:3/28/2017)... , March 28, 2017  Rosen Law Firm, a ... a class action lawsuit on behalf of purchasers of ... ) pursuant and/or traceable to Kitov,s initial public offering ... on the open market from November 20, 2015 through ... The lawsuit seeks to recover damages for Kitov investors ...
(Date:3/28/2017)... , March 29, 2017 ... Siteless CRO platform, announced today study results ... Managed Care Pharmacy, #AMCP2017, Managed Care and Specialty Pharmacy ... . Data in both posters demonstrated that pharmacist-led ... and protocol adherence. These factors are crucial to generating ...
(Date:3/28/2017)... , March 28, 2017 Emosis SAS, ... new business entity, Emosis Ltd, headquartered in Tel Aviv ... novel assays complementing the mother company existing technology platform and test ... sales development of Emosis kits. ... This strategic move starts building Emosis international footprint. Emosis ...
Breaking Medicine Technology: