Navigation Links
Study finds high CD4 cell counts associated with reduced risk of ischemic stroke for those with HIV
Date:6/24/2014

OAKLAND, Calif., June 24, 2014 A 15-year study found that HIV-positive individuals had a 40 percent increased risk of ischemic stroke, however stroke rates were nearly the same for HIV-positive individuals with high CD4 cell counts as for HIV-negative subjects.

The study, published recently in AIDS, the official journal of the International AIDS Society, covered the years 1996 through 2011 and included nearly 25,000 HIV-positive individuals.

Ischemic stroke is caused by plaque build-up in blood vessels, which can lead to constriction or actual obstruction of blood and oxygen flow to the brain. A CD4 cell count below 500 is considered a sign of a weakened immune system as it indicates lower numbers of white blood cells that fight infections and inflammation.

"Recent CD4 cell count was the strongest HIV-specific risk factor, suggesting an effect of current immunodeficiency on ischemic stroke risk," said senior author Michael J. Silverberg, PhD, MPH, an investigator with the Kaiser Permanente Division of Research in Oakland, California. "Notably, HIV-positive individuals with recent CD4 cell counts of 500 or more had no excess risk of ischemic stroke compared with HIV-negative individuals."

If the association between immunodeficiency on ischemic stroke risk is causal, the researchers concluded, early and consistent treatment with antiretroviral therapy to maintain immune function, combined with mitigation of stroke risk factors, may result in a similar risk of ischemic stroke among HIV-positive individuals compared with the general population.

"Our results suggest that maintenance of immune function may protect against ischemic stroke," said lead author Julia L. Marcus, PhD, MPH of the Division of Research. "Given recent calls to reduce or abandon CD4 monitoring among HIV-positive individuals with viral suppression, our data suggest that the CD4 cell count may be useful beyond its role in HIV disease monitoring."

The researchers found that, while ischemic stroke rates were higher over the entire study period, rates among HIV-positive individuals converged with rates for demographically-similar HIV-negative individuals by 2010-2011. A similar improved trend in risk of heart attack was observed previously in this same study cohort.

"As awareness of cardiovascular complications associated with antiretroviral therapy has increased, improved risk-factor management among HIV-positive individuals may have contributed to a decreasing risk over time," said co-author Daniel B. Klein, MD, chief of infectious diseases for Kaiser Permanente San Leandro. "It may also be that stroke risk has been mitigated by the earlier and wider use of antiretroviral therapy regimens with less cardiovascular risk."


'/>"/>

Contact: Samantha Purzak
spurzak@golinharris.com
202-585-2603
Kaiser Permanente
Source:Eurekalert

Related medicine news :

1. UCI study finds that learning by repetition impairs recall of details
2. For gastric bypass patients, percent of weight loss differs by race/ethnicity, study finds
3. New study offers potential avenues for treatment of deadly nasopharyngeal cancer
4. Long-term care must be improved to aid rising numbers with dementia, study finds
5. The ICEMAN study -- How keeping cool could spur metabolic benefits
6. New study explains how organs coordinate their development with the whole body
7. Study offers evidence that sunscreen use in childhood prevents melanoma in adults
8. Penn study reveals a common genetic link in fatal autoimmune skin disease
9. Pharmacy study expects to lower hospital readmissions
10. Study finds difference in way bipolar disorder affects brains of children versus adults
11. Proposed childrens study needs refinement, report finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic events ... turn to unhealthy avenues, such as drug or alcohol abuse, as a coping mechanism. ... tools for healthy coping following a traumatic event. , Trauma sufferers tend to feel ...
(Date:6/24/2016)... ... , ... Marcy was in a crisis. Her son James, eight, was out of control. Prone ... physically. , “When something upset him, he couldn’t control his emotions,” remembers Marcy. “If ... at my other children and say he was going to kill them. If we ...
(Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg Traurig, P.A. ... The attorneys chosen by their peers for this recognition are considered among the top ... Shareholders received special honors as members of this year’s Legal Elite Hall of Fame: ...
(Date:6/24/2016)... ... 2016 , ... Comfort Keepers® of San Diego, CA is excited to announce ... program to drive cancer patients to and from their cancer treatments. Comfort Keepers ... of life and ongoing independence. Getting to and from medical treatments is one ...
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. are sharpening their pencils ... an essay contest in which patients and their families pay tribute to a genetic ... 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016  Consumers have ... and regulators/payers have placed more emphasis on patient ... patient support programs in the pharmaceutical industry have ... medications. Consequently, pharmaceutical companies are focusing on becoming ... are providing products and services that improve health. ...
(Date:6/24/2016)... , June 24, 2016   Bay Area ... Network,s Dean Center for Tick Borne Illness ... and Rehabilitation, MIT Hacking Medicine, University of California, ... today announced the five finalists of Lyme ... disease.  More than 100 scientists, clinicians, researchers, entrepreneurs, ...
(Date:6/24/2016)... -- The Academy of Managed Care Pharmacy (AMCP) today ... allow biopharmaceutical companies to more easily share health care ... coverage decisions, a move that addresses the growing need ... The recommendations address restrictions in the sharing of product ... a prohibition that hinders decision makers from accessing HCEI ...
Breaking Medicine Technology: