Navigation Links
Study finds greater potential benefit in overall survival for eribulin compared with capecitabine
Date:6/12/2013

(Lebanon, NH, 6/11/13) Subgroup analyses from a phase III clinical trial comparing a newer chemotherapy agent called eribulin mesylate, with capecitabine, a standard chemotherapy medication in women with previously treated metastatic breast cancer, showed increased benefit among women sharing certain traits. Specifically, these analyses demonstrated a greater potential benefit in certain subsets of patients with metastatic breast cancer. This analysis was presented by Peter A. Kaufman, M.D., during the 2013 ASCO Annual Meeting.

The specific patient populations who appeared to benefit from eribulin, in comparison to capecitabine, are as follows:

  • Patients with more than two organs involved with metastatic breast cancer
  • Patients who had not received chemotherapy for six months or longer
  • Patients who had received anthracycline and/or a taxane therapies in the metastatic setting

Previous pre-specified exploratory analysis of overall survival and progression-free survival showed women with triple-negative, ER-negative, HER2-negative also had a greater relative benefit in overall survival with eribulin over capecitabine.

"These exploratory analyses suggest that other patient subgroups may benefit from eribulin and further studies are warranted," said Peter A. Kaufman, MD, associate professor of medicine at the Geisel School of Medicine at Dartmouth, and oncologist at Dartmouth-Hitchcock and Norris Cotton Cancer Center in Lebanon, N.H.

In 2010, the FDA approved eribulin for the treatment of patients with metastatic breast cancer who had previously received an anthracycline and a taxane and at least two cytotoxic chemotherapy treatment regimens for metastatic breast cancer. The FDA granted approval based on data showing a statistically significant improvement in overall survival compared with current treatments.

Kaufman and colleagues are still compiling data from the quality-
'/>"/>

Contact: Donna Dubuc
donna.m.dubuc@hitchcock.org
603-653-3615
Dartmouth-Hitchcock Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New Study Links Poor Sleep and Prostate Cancer
2. Researcher awarded grant to study food insecurity in homes of child with special healthcare needs
3. Study finds cancer guidelines do not fully meet IOM standards
4. Our Lady of Lourdes Medical Center & The Heart House Participating in Research Study Using Adult Stem Cells for Chronic Cardiac Condition
5. High Bit Security: 2/3 of All Data Breaches Preventable With Proactive Security Testing, New Ponemon Institute Study Documents Breach Causes and Costs
6. Alzheimer's Pilot Study Proposed for Ustekinumab (Stelara)
7. Capital Health Institute's Study Shows Migraine Headaches Prevalent Among Teen Girls
8. Workers do not quit due to mandatory flu shot, says Loyola study
9. Study finds obese mothers program their kids to be fat, but legacy can be overturned
10. Study shows cardiac MRI use reduces adverse events for patients with acute chest pain
11. Great HealthWorks, Makers of Omega XL, Report on New Omega-3 Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/31/2015)... ... August 31, 2015 , ... Cosmetic Town Journal is an ... to have a successful cosmetic procedure; from publishing encyclopedic medical articles to inform ... always ready to help. , It is clear that the Cosmetic Town aesthetic ...
(Date:8/31/2015)... ... August 31, 2015 , ... Dental clinicians from Newcastle University, ... Sciences to learn more about its integrated approach to diabetes care. , Philip ... of Cellular Medicine at Newcastle University, and Susan Bissett, National Institute for Health ...
(Date:8/31/2015)... Angeles, CA (PRWEB) , ... August 31, 2015 , ... When it comes to undergoing ... to the top of the head. Adding more volume to the hair on top ... procedure for patients who have a good amount of donor hair on other areas of ...
(Date:8/31/2015)... (PRWEB) , ... August 31, 2015 , ... ... insurance, announced today their new “ InstantQuote ” tool, which summarizes all available ... easy-to-understand format. The technology tool is designed to help India Network members make ...
(Date:8/31/2015)... ... , ... The Lisle family law firm of Momkus McCluskey, LLC ... peers to earn a “Leading Lawyers” distinction. , The “Leading Lawyers” ... Illinois. The nomination process is based on statewide peer survey nominations and the approval ...
Breaking Medicine News(10 mins):Health News:Cosmetic Town: A One Stop Plastic Surgery Community 2Health News:Western Diabetes Institute Collaborates with UK team 2Health News:Western Diabetes Institute Collaborates with UK team 3Health News:Western Diabetes Institute Collaborates with UK team 4Health News:Body Hair Transplants to Help Achieve a Full Head of Hair 2Health News:India Network proudly launches the new InstantQuote tool to help choose right visitor health insurance with pre-existing conditions to US bound visitors 2Health News:DuPage County Family Law Attorney Named Illinois Leading Lawyer 2
... possible in an effort to reverse its progression.Arthritis affects ... of disability in people over the age of 15, ... able to treat the disease and offer tips to ... genetic signs that indicate the early onset of arthritis. ...
... Orchid Chemicals & Pharmaceuticals Ltd today said it has ... New Drug Application) of Cephalexin oral suspension. // ... Chemicals' distribution alliance with US generic pharma major Par ... ,Orchid added that its Cephalexin capsules are already marketed ...
... the treatment of a 14-month-old Malaysian Indian baby who is suffering ... at the University Malaya Medical Centre, is suffering from the rare ... condition that is present at birth marked by a very small ... and there is cleft soft palate. ,Sreeram can ...
... conducted by Dr. Mark B. Landon of Ohio State University ... that it was not risky// to attempt vaginal delivery for ... ,The study results were published in the journal Obstetrics and ... for women who have had several previous cesarean deliveries to ...
... women with breast cancer have warned others to be wary ... been given a clean diagnosis in spite of having cancer.// ... Phillipa Naismith, 52, and Sandra Harley, 48, explained that they ... all clear by BreastScreen Queensland. They have now hired one ...
... a law that would protect HIV/AIDS patient's rights to privacy, ... for a woman with the right to seek an HIV ... is supposedly the country with the highest number of HIV/AIDS ... bill is being proposed to control this problem at the ...
Cached Medicine News:Health News:Researchers Beginning to Identify Genetic Culprits of Arthritis 2Health News:BreastScreen Australia Is Being Sued Towards Medical Negligence 2Health News:New Law On HIV/AIDS To Be Implemented At The Monsoon Session Of Parliament 2
(Date:8/31/2015)... 31, 2015  Asterias Biotherapeutics, Inc. (NYSE MKT: ... field of regenerative medicine, today announced that the ... Chicago -based Rush University Medical Center in ... escalating doses of AST-OPC1 (oligodendrocyte progenitor cells) in ... cervical spinal cord injury (SCI). This represents the ...
(Date:8/31/2015)... 2015   BioLife Solutions , Inc. (NASDAQ: ... marketer of proprietary clinical grade cell and tissue ... media and a related cloud hosted ... smart shippers ("BioLife" or the "Company"), today ... biopharmaceutical company focused on developing and commercializing novel ...
(Date:8/28/2015)... , Aug. 28, 2015  With the heroin ... reaching deadlier heights, Jacksonville -based Lakeview ... Hemphill is helping to explain why fentanyl is ... approximately 40 to 50 times more potent than pharmaceutical ... users as heroin, the risk of death skyrockets. ...
Breaking Medicine Technology:Asterias Biotherapeutics Concludes Recruitment of Initial Safety Cohort of the SCiStar Phase 1/2a Dose-Escalation Clinical Trial of AST-OPC1 for Complete Cervical Spinal Cord Injury 2Asterias Biotherapeutics Concludes Recruitment of Initial Safety Cohort of the SCiStar Phase 1/2a Dose-Escalation Clinical Trial of AST-OPC1 for Complete Cervical Spinal Cord Injury 3Asterias Biotherapeutics Concludes Recruitment of Initial Safety Cohort of the SCiStar Phase 1/2a Dose-Escalation Clinical Trial of AST-OPC1 for Complete Cervical Spinal Cord Injury 4Asterias Biotherapeutics Concludes Recruitment of Initial Safety Cohort of the SCiStar Phase 1/2a Dose-Escalation Clinical Trial of AST-OPC1 for Complete Cervical Spinal Cord Injury 5Asterias Biotherapeutics Concludes Recruitment of Initial Safety Cohort of the SCiStar Phase 1/2a Dose-Escalation Clinical Trial of AST-OPC1 for Complete Cervical Spinal Cord Injury 6BioLife Solutions Customer TiGenix Phase 3 Clinical Trial Meets Primary Endpoint 2BioLife Solutions Customer TiGenix Phase 3 Clinical Trial Meets Primary Endpoint 3BioLife Solutions Customer TiGenix Phase 3 Clinical Trial Meets Primary Endpoint 4BioLife Solutions Customer TiGenix Phase 3 Clinical Trial Meets Primary Endpoint 5Lakeview Health's Dr. Philip Hemphill Explains Why Heroin Addicts Are Now Dying of Fentanyl Overdoses 2
... (OTCQX: DATA), a technology and services company focused on global ... its Vice President of Research and Development, Chris Wilke, has ... 2009 Society for Clinical Data Management (SCDM) Annual Conference which ... Mr. Wilke will be discussing Is 100% EDC Realistic? ...
... ThermalTherapeutic Systems, Inc., developers of a highly ... today the completion of $2.75 Million Series A ... funding by the Pittsburgh Life Sciences Greenhouse, and ... investments by the Pittsburgh Life Sciences Greenhouse and ...
Cached Medicine Technology:DATATRAK to Present at 2009 SCDM Annual Conference 2DATATRAK to Present at 2009 SCDM Annual Conference 3ThermalTherapeutic Systems Completes $2.75 Million Series A Financing With Originate Ventures 2
The Natural Selection family of specialty allografts is spinal concepts response to surgeon requests for spinal allograft devices to eliminate the need for painful autograft harvesting....
Transcranial vascular DWL doppler....
Transcranial vascular DWL doppler....
... Neurocare is a full-featured physiologic testing system offered ... contains many of the features of our flagship ... economical price. , ,The smaller size of the ... environment, the physician's office, a mobile service or ...
Medicine Products: