Navigation Links
Study finds good outcomes for older lung transplant patients
Date:2/4/2008

In the world of organ donation, it has been common practice to exclude older patients from receiving transplants because of limited donor supply and lower survival rates.

However, patients such as Lois Tumanello, who received a successful lung transplant at 65, are proving that perhaps age does not always matter.

A new UCLA Medical Center study shows that select patients age 65 and older can safely undergo lung transplantation and have acceptable outcomes. The findings are reported in the February issue of the peer-reviewed Journal of Thoracic and Cardiovascular Surgery.

Since 1999, UCLA has been one of the few transplant centers in the country to offer lung transplants to patients 65 and older who were otherwise healthy candidates for the procedure.

"Over the past decade, various reports have shown that older recipients undergoing all types of solid-organ transplantation can have good outcomes," said study co-author Dr. Abbas Ardehali, associate professor of cardiothoracic surgery and director of the UCLA Lung Transplant Program. "We wanted to define the short- and medium-term outcomes of lung transplantation in these older patients to determine whether the outcomes were acceptable."

The study reviewed records of UCLA patients who received lung transplants between March 2000 and September 2006. During this period, 50 transplant surgeries were performed on 48 patients between the ages of 65 and 72. A group of 50 patients younger than 65 were matched to the older cohort for comparison purposes.

Survival rates for both groups were similar. The early survival rate of the older patients was 95.7 percent, compared with 95.9 percent for the younger cohort. The one-year survival rate was 79.7 percent for the older group and 91.2 percent for the younger, and the three-year survival rate was 73.6 for the older group and 74.2 percent for the younger.

Researchers found that older patients were more likely to receive single-lung transplants (76 percent, compared with 16 percent for the younger group) and to receive nonstandard lungs (46 percent, compared with 28 percent). Nonstandard lungs are those considered "less than perfect" but still acceptable for transplantation.

The study's findings suggest that the increased mortality rate among older patients during the period from one month to one year following transplantation due predominantly to infection may result from immunosenescence, the gradual deterioration of the immune system with age.

"This finding warrants adjustments in the immunosuppresion protocols for older patients," said lead author Dr. Raja Mahidhara, UCLA assistant professor of cardiothoracic surgery. "In addition, future studies should look at the effects of lung transplantation in older recipients on the donor pool and on other, younger patients on the waiting list."

Tumanello, now 66, suffered from emphysema for more than nine years before receiving a single-lung transplant at UCLA in March 2007. Since then, she said, she has felt wonderful and has been enjoying the freedom to go anywhere and do anything she wants. Married, with three grown children and five grandchildren, Tumanello says she is grateful every day for the generous gift she received and is committed to taking care of her new lung.

"I think everyone should be given a chance," she said.


'/>"/>

Contact: Amy Albin
aalbin@mednet.ucla.edu
310-794-8672
University of California - Los Angeles
Source:Eurekalert

Related medicine news :

1. Study Finds Women Pay More Attention to Their Hair Than Their Hearts
2. Ear Wax Softener Can Affect Hearing, Study Reports
3. Patient Alert: New Study Finds Most Organ Transplant Patients Are Unaware of Their Increased Risk for Skin Cancer
4. New Study Finds Frequent Hand Washing Puts Health Care Workers at Increased Risk for Irritant Contact Dermatitis
5. Study finds widespread vitamin and mineral use among cancer survivors
6. New Study Shows Isolaz Can Reduce Acne Up to 90 Percent
7. Journal Sleep: Study concludes a daytime nap can benefit a persons memory performance
8. MITs McGovern Institute researchers awarded $8.5M to study brain basis of autism and dyslexia
9. Study Spots Gene That Plays Role in Infertility
10. Kiadis Pharma Announces Successful Completion of Rhitol(TM) Phase II Clinical Study
11. Top hospitals have 27 percent lower mortality, annual HealthGrades study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... , ... December 02, 2016 , ... ... announced today that it has raised $6.0 million in an initial round of ... Health’s conviction that patients and their caregivers can receive far better care through ...
(Date:12/2/2016)... Grants Pass, OR (PRWEB) , ... December 02, ... ... Daryl Wein, Medical Technologist/Clinical Laboratory Scientist & Author of Type 2 Diabetes: The ... and host of The Sharon Kleyne Hour Power of Water, Global Climate Change ...
(Date:11/30/2016)... ... November 30, 2016 , ... ... offer a comprehensive in-house dental plan for all patients. Understanding that budget can ... that gives patients a number of perks, including discounts on many valuable dental ...
(Date:11/30/2016)... ... November 30, 2016 , ... Center For Discovery, a nationally ... of a new eating disorder treatment center location in Palm Beach Gardens, Florida.  The ... adolescents, both males and females ages 10 and older with eating disorders, including ...
(Date:11/30/2016)... ... November 30, 2016 , ... The ... stylish design wanted by today’s consumers at an affordable price, is now available ... the new watch is “a game changer” when it comes to the smartwatch. ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... , Dec 1, 2016 Research ... "Drug Delivery in Cancer - Technologies, Markets and Companies" ... , ... challenge in management of cancer The market value of ... Cancer market estimates from 2015-2025 are given according to organs involved ...
(Date:12/2/2016)... pleased to announce that 12 scientific abstracts have been accepted ... Epilepsy Society (AES) Annual Meeting, which takes place from 2-6 ... Data being presented include posters further ... (lacosamide) CV and BRIVIACT ® (brivaracetam) CV. 2,3,4,6,8 ... the union of epilepsy care and antiepileptic drugs in the ...
(Date:11/30/2016)... -- Research and Markets has announced the addition of ... MedCore" report to their offering. ... , The cerebrospinal fluid (CSF) ... individuals, it is circulated though the brain and its ventricles, the spine ... CSF surrounding the brain changes significantly. As a ...
Breaking Medicine Technology: