Navigation Links
Study finds genetic influence on pace of HIV/AIDS progression
Date:10/22/2007

What: Viral loadthe amount of virus in the blood of an HIV-infected personhas long been viewed as the chief indicator of how quickly someone infected with HIV infection progresses to AIDS. New data published in Nature Immunology builds on previous work that suggests that several other factors in addition to viral load significantly contribute to disease progression rates.

Researchers led by Sunil Ahuja, M.D., of the University of Texas Health Science Center in San Antonio, examined genetic information from more than 3,500 HIV-1 infected and uninfected individuals. They found that individuals who had specific combinations of two genesCCR5, which helps facilitate HIV entry into the cell, and CCL3L1, an immune response genewere much more likely to have reduced immune responses and a greater decline in CD4 T cells, two hallmarks of progressive HIV disease. Further, the researchers found that in HIV-infected subjects, viral load contributed only 9 percent to the variability in rate of progression to AIDS; variations in CCR5 and CCL3L1 combined accounted for 6 percent variability in AIDS progression rates.

The findings may have implications for the care of HIV-infected individuals in terms of being able to more effectively predict the course of HIV disease. With further research, this work may lead to additional markers, which along with viral load may serve as indicators of HIV progression. The study was funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.


'/>"/>

Contact: NIAID News Office
niaidnews@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Page: 1

Related medicine news :

1. Rural Canadians travel far for specialists: study
2. A new study surpasses Gene Therapy Hurdle
3. Tomato Sauce reduces Cancer Risk- Study
4. A question on study of Adult Stem Cell
5. Study on obesity and heart failure
6. National Lung Study in the process
7. Marijuana gateway theory strengthened by study of twins
8. Old theory of adaptation confirmed by new study
9. Study casts doubt on keyboard ills
10. Gene study links endometriosis, infertility
11. Study reveals how stress can make you sick
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/8/2016)... ... 2016 , ... CURE Media Group, the nation’s leading digital and print media ... Lung Cancer in efforts to combat lung cancer, announced CURE Media Group President Michael ... Media Group is honored to team up with Upstage Lung Cancer in order to ...
(Date:12/8/2016)... ... ... With the increasing demand for dental implants, the National Association of Dental Laboratories ... and patients about the safety issues related to dental restorations. According to the American ... projected to reach $6.4 billion in 2018 with more than 30 million Americans missing ...
(Date:12/8/2016)... ... 2016 , ... David J. Dykeman , Ginger Pigott , and ... speak at DeviceTalks West, Dec. 12, 2016, at the Fairmont Newport Beach in California. ... firm’s global Life Sciences & Medical Technology Group have been featured speakers at every ...
(Date:12/8/2016)... ... ... Premier Fitness Camp (PFC) and The Chopra Center for Wellbeing announced today the ... their world headquarters of Omni La Costa Resort & Spa in San Diego. , ... loss, personal development, a healthy lifestyle, or mental and physical healing. The week-long wellness ...
(Date:12/8/2016)... ... December 08, 2016 , ... SunView ... customers and employees that are both engaging and easy to use. Coming off ... the software company revealed today its plans to roll out new AI-powered self-service ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... 2016 Bodycad announced it has been ... accuracy, reproducibility and speed for 3D constructs via ... bone orthopaedic applications. These patents are critical to ... restorations based on each patient,s distinct anatomy. ... harnesses the world,s first suite of orthopaedic CAD/CAM ...
(Date:12/8/2016)... 2016  Pennsylvania Physician General Dr. Rachel ... Programs Gary Tennis released safe prescribing ... benzodiazepines, developed with the help of a task ... are frequently prescribed for anxiety or insomnia," said ... opioid pain medications, benzodiazepines pose a significant risk ...
(Date:12/8/2016)... , Dec. 8, 2016  Valeant Pharmaceuticals ... TSX: VRX) ("Valeant") today announced positive results from ... study to assess the safety and efficacy of ... treatment of plaque psoriasis. Within ... with moderate to severe psoriasis, IDP-118 showed statistical ...
Breaking Medicine Technology: