Navigation Links
Study finds genes associated with hippocampal atrophy
Date:6/28/2012

(Boston) -- In a genome-wide association (GWA) study, researchers from Boston University Schools of Medicine (BUSM) and Public Health (BUSPH) have identified several genes which influence degeneration of the hippocampus, the part of the brain most associated with Alzheimer disease (AD). The study, which currently appears online as a Rapid Communication in the Annals of Neurology, demonstrates the efficacy of endophenotypes for broadening the understanding of the genetic basis of and pathways leading to AD.

AD is a progressive neurodegenerative disorder for which there are no prevention methods. Available drugs only marginally affect disease severity and progression, making AD effectively untreatable.

GWA studies using very large samples have increased the number of robust associations to 10 genes, including APOE. However, these genes account for no more than 35 percent of the inherited risk of AD and most of the genetic underpinning of the disorder remains unexplained. According to the researchers, magnetic resonance imaging (MRI) of the brain provides in vivo quantitative measures of neurodegenerative and cerebrovascular brain injury that may represent AD-related changes long before clinical symptoms appear. These measures are more powerful than comparisons of individuals with AD with cognitively healthy persons because they avoid misclassification of normal persons who will develop disease in the future.

BUSM researchers conducted a two-stage GWA study for quantitative measures of hippocampal volume (HV), total cerebral volume (TCV) and white matter hyperintensities (WMH). Brain MRI measures of HV, TCV and WMH were obtained from 981 Caucasian and 419 African-American AD cases and their cognitively normal siblings in the MIRAGE (Multi Institutional Research in Alzheimer's Genetic Epidemiology) Study. In addition, similar MRI measures were obtained from 168 AD cases, 336 individuals with mild cognitive impairment and 188 co
'/>"/>

Contact: Gina DiGravio
gina.digravio@bmc.org
617-638-8480
Boston University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Study Suggests Vaccine May Help Kids With Brain Cancer
2. Study reveals how cancer drug causes diabetic-like state
3. Coffee Drinking in Pregnancy Wont Lead to Sleepless Baby: Study
4. Lower GI problems plague many with rheumatoid arthritis, Mayo Clinic study finds
5. Veggies Like Broccoli, Cabbage May Help Fight Breast Cancer: Study
6. No Added Cancer Risk From Hip Replacement Materials: Study
7. Reported Decline in U.S. Pneumonia Deaths May Be False: Study
8. Early Study Finds Some Promise for Lung Cancer Vaccine
9. Narcissists Often Ace Job Interviews, Study Finds
10. Sexual objectification of female artists in music videos exists regardless of race, MU study finds
11. Soy may alleviate hot flashes in menopause, large-scale study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2014)... 23, 2014 WetKeys Washable Keyboards announces ... in their industrial keyboards line. Labeled ... to last longer in heavy-duty industrial computing for the ... where grease and oil can destroy usability or cause ... constant threat to the longevity of computer equipment and ...
(Date:9/23/2014)... September 23, 2014 Névo takes a ... precision timepiece and adding advanced activity tracking and phone ... monitors steps, distance, calories burned, and more. , ... to adopt healthy habits in their busy lives to ... small changes that produce healthy results, but until now, ...
(Date:9/23/2014)... (PRWEB) September 23, 2014 Many people have ... Everyone has seen nightclub or television acts in which a ... members and then uses the power of suggestion to have ... have also heard about hypnosis as an aid in managing ... only a fraction of the ways hypnotism can be used. ...
(Date:9/23/2014)... Texas (PRWEB) September 23, 2014 Medicine in ... its central Austin location at 711 W. 38th, Suite G4. ... at their north Austin location, increased demand for MIM’s superior ... “My team and I are extremely excited about bringing our ... Martha Pyron, owner of Medicine in Motion. “We’ll continue to ...
(Date:9/23/2014)... Recently, BuyTopDress.com, a popular supplier of wedding dresses and special ... fashionable marine ball dresses . Along with this, the ... brand new items; all of them are now provided with ... now, BuyTopDress.com has won more than 2000 happy customers in ... its products and after-sale services. The company is offering thousands ...
Breaking Medicine News(10 mins):Health News:WetKeys Announces New Oil Resistant Keyboard for Industrial Computing, Food Processing Plants, Automotive Factories and Machine Shops 2Health News:WetKeys Announces New Oil Resistant Keyboard for Industrial Computing, Food Processing Plants, Automotive Factories and Machine Shops 3Health News:WetKeys Announces New Oil Resistant Keyboard for Industrial Computing, Food Processing Plants, Automotive Factories and Machine Shops 4Health News:WetKeys Announces New Oil Resistant Keyboard for Industrial Computing, Food Processing Plants, Automotive Factories and Machine Shops 5Health News:Nevo changes the face of fitness wearables with an analogue watch combining activity tracking, phone notifications, and LED goal progress indicators for active lifestyles 2Health News:Nevo changes the face of fitness wearables with an analogue watch combining activity tracking, phone notifications, and LED goal progress indicators for active lifestyles 3Health News:Hypnosis: What You Don't Know, Dr. Richard Dauber with Morris Psychological Group Dispels Myths and Offers Tips about a Valuable Therapeutic Approach 2Health News:Hypnosis: What You Don't Know, Dr. Richard Dauber with Morris Psychological Group Dispels Myths and Offers Tips about a Valuable Therapeutic Approach 3Health News:Hypnosis: What You Don't Know, Dr. Richard Dauber with Morris Psychological Group Dispels Myths and Offers Tips about a Valuable Therapeutic Approach 4Health News:Austin Sports Medicine Practice to Host Grand Opening Event for Second Location 2Health News:Fashionable Marine Ball Dresses Added To BuyTopDress.com’s Collection 2
... detected with self-illuminating polymers. The originators, at Linkping University ... can also render the prions harmless, and potentially cure ... at the University Hospital in Zrich tested the luminescent ... brains of mice that had been infected with prions. ...
... controlled by lightning-quick electrical impulses in the brain, the ... in the membranes of the cells can cause things ... Linkping University has now published new discoveries that can ... key molecules behind the electrical impulses are voltage-activated ion ...
... cellular protein called HDAC6, newly characterized as a gatekeeper ... novel target for treating and preventing stress-linked disorders, such ... research from the Perelman School of Medicine at the ... secreted by the body during stress. A small amount ...
... (HealthDay News) -- The shingles vaccine is generally safe and ... Shingles, which affects more than 1 million people each year ... by the dormant chickenpox virus, which can reactivate and replicate, ... risk because immunity against the virus that causes shingles declines ...
... Canada demonstrated the unequivocal effectiveness of brain surgeries for ... not been widely adoptedin fact, it is dramatically underutilized ... California, San Francisco (UCSF). The study, published this ... the number of Americans having the surgery has not ...
... , MONDAY, April 23 (HealthDay News) -- It goes without ... dangerous, but they can also be very expensive, an expert ... uncommon for a person bitten by a venomous snake, said ... A&M University in College Station. The total cost includes ...
Cached Medicine News:Health News:Prions in the brain eliminated by homing molecules 2Health News:Molecule movements that make us think 2Health News:Gatekeeper of brain steroid signals boosts emotional resilience to stress 2Health News:Gatekeeper of brain steroid signals boosts emotional resilience to stress 3Health News:Shingles Vaccine Safe, Underutilized, Study Says 2Health News:Brain surgery for epilepsy underutilized 2Health News:Brain surgery for epilepsy underutilized 3Health News:Cost of Snakebite Therapy May Squeeze Victims' Wallets 2
(Date:9/22/2014)... , Sept. 22, 2014  Neuralstem, Inc. (NYSE MKT: CUR) ... investigator at Emory University, presented long-term follow up data ... stem cells in the treatment of amyotrophic lateral sclerosis ... which occurred at the Annual Symposium on ALS of ... , on Friday, and was not open to the ...
(Date:9/22/2014)... Pa. , Sept. 22, 2014  Olympus, ... innovative solutions for medical and surgical procedures, among ... a deal with Munich -based ... Kick ® Navigation. This agreement applies to ... for cross-disciplinary U.S. sales and all distribution outside ...
(Date:9/22/2014)... MEETING, Pa. , Sept. 22, 2014 /PRNewswire/ ... announced today it has initiated a phase I ... trial will evaluate the safety, tolerability, and immunogenicity ... 6 (HPV-6), which causes most aerodigestive cancers. ... nose, throat, vocal cords, and parts of the ...
Breaking Medicine Technology:Neuralstem ALS Investigator Presents Long-Term Follow Up Phase I Data 2Neuralstem ALS Investigator Presents Long-Term Follow Up Phase I Data 3Neuralstem ALS Investigator Presents Long-Term Follow Up Phase I Data 4Olympus Partners with Brainlab as Exclusive Distributor for ENT Products in U.S. Market 2Olympus Partners with Brainlab as Exclusive Distributor for ENT Products in U.S. Market 3Olympus Partners with Brainlab as Exclusive Distributor for ENT Products in U.S. Market 4Inovio Pharmaceuticals Expands HPV Immunotherapy Development to Aerodigestive Cancers 2Inovio Pharmaceuticals Expands HPV Immunotherapy Development to Aerodigestive Cancers 3Inovio Pharmaceuticals Expands HPV Immunotherapy Development to Aerodigestive Cancers 4
... Mylan Inc. (Nasdaq: MYL ) today announced ... from the U.S. Food and Drug Administration (FDA) for its ... 8.5 mg, 17 mg, 25.5 mg and 34 mg. Mylan ... ANDA containing a Paragraph IV certification for Nisoldipine ER Tablets ...
... Inc. (Amex: AEN ), a developer of innovative ... it has executed an agreement for the sale of approximately ... share to two new institutional investors in a registered direct ... also receive warrants to purchase approximately 1.42 million shares of ...
Cached Medicine Technology:Adeona to Raise $4 Million in Registered Direct Offering 2Adeona to Raise $4 Million in Registered Direct Offering 3
... help you meet the challenges of anterior ... creates a broad area for fusion to ... slotted superior and inferior platforms facilitate bone ... flared outward for greater surface contact. The ...
... the use of plates and screws in the treatment ... pins in the forearm or ankle is not a ... lock the pins or hold them in place. A ... out of the implant. The SST® (Stainless Steel Taper) ...
... 1056K LV lead is designed to ... shorter procedure times, delivering a complete ... ,The QuickSite LV lead is a ... lead, including such features as S-shaped ...
... 36 cc and 73 grams, the Epic ... care and simplified follow-up. The Epic HF ... 30 joule (delivered energy) biventricular ICD. Small ... HF ICD features advanced resynchronization parameters along ...
Medicine Products: