Navigation Links
Study finds difference in way bipolar disorder affects brains of children versus adults
Date:6/18/2014

PROVIDENCE, R.I. A new study from Bradley Hospital has found that bipolar children have greater activation in the right amygdala a brain region very important for emotional reaction than bipolar adults when viewing emotional faces. The study, now published online in JAMA Psychiatry, suggests that bipolar children might benefit from treatments that target emotional face identification, such as computer based "brain games" or group and individual therapy.

This study is the first ever meta-analysis to directly compare brain changes in bipolar children to bipolar adults, using data from 100 functional MRI (fMRI) brain imaging studies with a pool of thousands of participants. Ezra Wegbreit, Ph.D., a postdoctoral research fellow at Bradley Hospital, led the study along with senior author Daniel Dickstein, M.D., director of the PediMIND Program at Bradley Hospital.

"Bipolar disorder is among the most debilitating psychiatric illnesses affecting adults worldwide, with an estimated prevalence of one to four percent of the adult population, but more than 40 percent of adults report their bipolar disorder started in childhood rather than adulthood," said Wegbreit. "Despite this, very few studies have examined whether brain or behavioral changes exist that are specific to children with bipolar disorder versus adults with bipolar disorder."

While fMRI studies have begun to investigate the neural mechanisms underlying bipolar disorder, few have directly compared differences in youths with bipolar disorder and bipolar adults. To address this gap, the research team conducted the large scale meta-analyses, directly comparing fMRI findings in bipolar youths versus bipolar adults, both relative to non-bipolar participants.

Analysis of emotional face recognition fMRI studies showed significantly greater amygdala activity among bipolar youths than bipolar adults. The team also analyzed studies using emotional stimuli, which again showed significantly greater levels of brain activation in bipolar children, this time in the inferior frontal gyrus and precuneus areas of the brain. In contrast, analyses of fMRI studies using non-emotional cognitive tasks showed a significant lack of brain activation in the anterior cingulate cortex of bipolar children.

"Our meta-analysis has located different regions of the brain that are either hyper active or under active in children with bipolar disorder," said Wegbreit. "These point us to the targeted areas of the brain that relate to emotional dysfunction and cognitive deficits for children with bipolar disorder."

"Despite our best current treatments, bipolar disorder exacts a considerable toll on youths, including problems with friends, parents and at school, and high rates of psychiatric hospitalization and suicide attempts," said Dickstein. "More research into targeted treatments is needed now that we know children's brains are impacted in specific, identifiable ways by bipolar disorder."

Dickstein added that Bradley Hospital's PediMIND Program is currently conducting several research projects on pediatric bipolar disorder, including potential brain-based treatment. "Understanding more about the brains of children and adults with mental illness is very important because, ultimately, all mental illnesses are reflected in changes in brain activity," said Dickstein. "Locating the underlying brain change in bipolar youths could lead us to new, brain-based ways to improve how we diagnose and treat this disorder."

Ongoing studies by the PediMIND Program and other research groups are working to determine if computer-based "brain games" or group or individual therapy might improve these brain changes in a more targeted way, and improve the lives of children and adults with bipolar disorder.


'/>"/>

Contact: Jill Reuter
jreuter@lifespan.org
401-444-6863
Lifespan
Source:Eurekalert

Related medicine news :

1. Proposed childrens study needs refinement, report finds
2. Study examines how brain reboots itself to consciousness after anesthesia
3. U of MD researchers receive NIH grant to study personalized medicine for genetic diabetes
4. New study is first to identify, clarify MERS-related abnormality distribution on CT
5. Study shows cost-effectiveness of smoking cessation counseling during hospitalization
6. TGen and Scottsdale Healthcare begin study of new drug for patients with solid tumors
7. Gut bacteria predict survival after stem cell transplant, study shows
8. E-cigs heavily marketed on Twitter, study finds
9. Caffeine affects boys and girls differently after puberty, study finds
10. UTMB to participate in $30 million national study to prevent falls in older people
11. Moffitt study shows utilizing genetic health care professional reduces unnecessary testing
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/20/2017)... ... ... to Christmas:” a beautiful and enchanting tale that teaches children the true meaning of Christmas. ... in Oklahoma City, and a devoted woman of faith. , “Becoming a parent changes ... back of my mind for years, but actually doing it might have been a while ...
(Date:1/20/2017)... ... January 20, 2017 , ... “The Land of More and More”: ... issue of world hunger, and shares the simple and achievable answer. “The Land of ... member of the Fairview Missionary Church in Angola, Indiana where he works with the ...
(Date:1/19/2017)... ... January 20, 2017 , ... Today, the Centers for Medicare ... four of CMS’s Alternative Payment Models (APMs) in 2017. Clinicians who participate in APMs ... are an important part of the Administration’s effort to build a system that delivers ...
(Date:1/19/2017)... ... January 19, 2017 , ... Next week after January 20th, the ... Congressional political games that circumvent health needs of over 30 million. Many interviews with ... anxieties and needs government public servants were suppose to prioritize. Interviews provided below. ...
(Date:1/19/2017)... (PRWEB) , ... January 19, 2017 , ... With the cold weather here, many people ... Snow blowers are efficient when clearing large amounts of snow, but they can be dangerous ... the U.S. Consumer Product Safety Commission for the proper use of snow blowers:, ...
Breaking Medicine News(10 mins):
(Date:1/21/2017)... , Jan 20, 2017 Research and Markets ... Analysis & Trends - Technology, Route Of Administration, End User - ... ... is poised to grow at a CAGR of around 7.8% over ... This industry report analyzes the global markets for Advanced ...
(Date:1/20/2017)... -- Research and Markets has announced the addition ... BMP, BUN Creatinine, Electrolyte Testing, HbA1c Testing, Comprehensive Metabolic Panel, Liver ... - 2024" report to their offering. ... The global clinical laboratory testing market ... Introduction of innovative solutions on the grounds of maximum efficiency and ...
(Date:1/20/2017)... 20, 2017  Ethicon Endo-Surgery, Inc. announced ... Products, Inc., a privately held medical device ... tools used in operating rooms worldwide. The ... advanced energy devices with Megadyne,s innovative portfolio ... forward in Ethicon,s goal to deliver the ...
Breaking Medicine Technology: