Navigation Links
Study finds difference in way bipolar disorder affects brains of children versus adults
Date:6/18/2014

PROVIDENCE, R.I. A new study from Bradley Hospital has found that bipolar children have greater activation in the right amygdala a brain region very important for emotional reaction than bipolar adults when viewing emotional faces. The study, now published online in JAMA Psychiatry, suggests that bipolar children might benefit from treatments that target emotional face identification, such as computer based "brain games" or group and individual therapy.

This study is the first ever meta-analysis to directly compare brain changes in bipolar children to bipolar adults, using data from 100 functional MRI (fMRI) brain imaging studies with a pool of thousands of participants. Ezra Wegbreit, Ph.D., a postdoctoral research fellow at Bradley Hospital, led the study along with senior author Daniel Dickstein, M.D., director of the PediMIND Program at Bradley Hospital.

"Bipolar disorder is among the most debilitating psychiatric illnesses affecting adults worldwide, with an estimated prevalence of one to four percent of the adult population, but more than 40 percent of adults report their bipolar disorder started in childhood rather than adulthood," said Wegbreit. "Despite this, very few studies have examined whether brain or behavioral changes exist that are specific to children with bipolar disorder versus adults with bipolar disorder."

While fMRI studies have begun to investigate the neural mechanisms underlying bipolar disorder, few have directly compared differences in youths with bipolar disorder and bipolar adults. To address this gap, the research team conducted the large scale meta-analyses, directly comparing fMRI findings in bipolar youths versus bipolar adults, both relative to non-bipolar participants.

Analysis of emotional face recognition fMRI studies showed significantly greater amygdala activity among bipolar youths than bipolar adults. The team also analyzed studies using emotional stimuli, which again showed significantly greater levels of brain activation in bipolar children, this time in the inferior frontal gyrus and precuneus areas of the brain. In contrast, analyses of fMRI studies using non-emotional cognitive tasks showed a significant lack of brain activation in the anterior cingulate cortex of bipolar children.

"Our meta-analysis has located different regions of the brain that are either hyper active or under active in children with bipolar disorder," said Wegbreit. "These point us to the targeted areas of the brain that relate to emotional dysfunction and cognitive deficits for children with bipolar disorder."

"Despite our best current treatments, bipolar disorder exacts a considerable toll on youths, including problems with friends, parents and at school, and high rates of psychiatric hospitalization and suicide attempts," said Dickstein. "More research into targeted treatments is needed now that we know children's brains are impacted in specific, identifiable ways by bipolar disorder."

Dickstein added that Bradley Hospital's PediMIND Program is currently conducting several research projects on pediatric bipolar disorder, including potential brain-based treatment. "Understanding more about the brains of children and adults with mental illness is very important because, ultimately, all mental illnesses are reflected in changes in brain activity," said Dickstein. "Locating the underlying brain change in bipolar youths could lead us to new, brain-based ways to improve how we diagnose and treat this disorder."

Ongoing studies by the PediMIND Program and other research groups are working to determine if computer-based "brain games" or group or individual therapy might improve these brain changes in a more targeted way, and improve the lives of children and adults with bipolar disorder.


'/>"/>

Contact: Jill Reuter
jreuter@lifespan.org
401-444-6863
Lifespan
Source:Eurekalert

Related medicine news :

1. Proposed childrens study needs refinement, report finds
2. Study examines how brain reboots itself to consciousness after anesthesia
3. U of MD researchers receive NIH grant to study personalized medicine for genetic diabetes
4. New study is first to identify, clarify MERS-related abnormality distribution on CT
5. Study shows cost-effectiveness of smoking cessation counseling during hospitalization
6. TGen and Scottsdale Healthcare begin study of new drug for patients with solid tumors
7. Gut bacteria predict survival after stem cell transplant, study shows
8. E-cigs heavily marketed on Twitter, study finds
9. Caffeine affects boys and girls differently after puberty, study finds
10. UTMB to participate in $30 million national study to prevent falls in older people
11. Moffitt study shows utilizing genetic health care professional reduces unnecessary testing
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... Lafayette, California (PRWEB) , ... ... ... a pioneer in the patient payment industry today announced its strategic partnership ... and health system workflows. , The two companies’ proven, proprietary technology combine ...
(Date:6/27/2016)... ... ... TopConsumerReviews.com recently awarded their highest five-star rating to Best Buy Eyeglasses, an ... United States and Canada wear eyeglasses. Once considered to be a purely functional part ... fashion statement. Even celebrities use glasses as a way of creating an iconic image—like ...
(Date:6/26/2016)... ... June 26, 2016 , ... On June 10-11, 2016, A Forever Recovery, ... Festival and World’s Longest Breakfast Table in Battle Creek, MI, where the rehabilitation facility ... home to some of the world’s leading providers of cereal and other breakfast foods. ...
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet ... product that was developed to enhance the health of felines. The formula is all-natural ... two main herbs in the PawPaws Cat Kidney Support Supplement Soft Chews ...
(Date:6/26/2016)... Clarkston, Michigan (PRWEB) , ... June 26, 2016 ... ... respect to fertility once they have been diagnosed with endometriosis. These women need ... but they also require a comprehensive approach that can help for preservation of ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 24, 2016   Pulmatrix, Inc ., (NASDAQ: ... inhaled drugs, announced today that it was added to ... its comprehensive set of U.S. and global equity ... an important milestone for Pulmatrix," said Chief Executive Officer ... of our progress in developing drugs for crucial unmet ...
(Date:6/24/2016)... 24, 2016  Arkis BioSciences, a leading innovator ... more durable cerebrospinal fluid treatments, today announced it ... funding is led by Innova Memphis, followed by ... private investors.  Arkis, new financing will accelerate the ... market release of its in-licensed Endexo® technology. ...
(Date:6/23/2016)... Research and Markets has announced the addition of ... report to their offering. ... kidney failure, it replaces the function of kidneys by removing ... thus the treatment helps to keep the patient body,s electrolytes ... Increasing number of ESRD patients & substantial healthcare expenditure ...
Breaking Medicine Technology: