Navigation Links
Study finds changes in fetal epigenetics throughout pregnancy
Date:4/14/2010

Researchers at Mount Sinai School of Medicine have found that epigenetic marks on human placentas change from the first trimester of pregnancy to the third, a discovery that may allow clinicians to prevent complications in pregnancy.

The finding marks a dramatic departure from the prevailing opinion that epigenetic programming is permanently established 12 weeks after fertilization. Published in the April issue of the American Journal of Obstetrics and Gynecology, the study indicates that clinicians may be able to change the course of a pregnancy through early diagnosis and treatment.

"Our research shows that there are several 'windows of opportunity' during pregnancy to detect risks and also change pregnancy outcomes that may arise later," said the study's senior investigator, Men-Jean Lee, MD, Associate Professor, Obstetrics, Gynecology and Reproductive Science, and Preventive Medicine, Mount Sinai School of Medicine. "We have developed an assay that can allow clinicians to diagnose problems early enough to potentially prevent conditions such as preeclampsia and fetal growth restriction."

Epigenetics generally refers to factors that modify how a gene behaves while not altering the DNA nucleotide sequence of the gene itself. The placenta contains a group of genes, known as "imprinted" genes, which regulate fetal growth. In healthy fetal development, one copy of these genes is normally active and the other copy is silent. Loss of imprinting (LOI) occurs when both sets of genes are reactivated, and is an indicator of potential complications such as preeclampsia and fetal growth restriction.

Using an LOI assay developed by James G. Wetmur, PhD, and Jia Chen, ScD, of Mount Sinai School of Medicine, the research team assessed LOI at the first trimester in 17 placentas and at full term in 14 different placentas. The surprising results showed that more LOI occurred in the first trimester than at full term.

Dr. Lee and her team concluded that genomic imprinting appears to be an ever-changing process in the placenta, meaning that pregnancy risks can change throughout the course of gestation. Previously, the medical community believed imprints remained static after 12 weeks. This same Mount Sinai research team had also previously discovered that the epigenetic marks in placentas from pregnancies with preeclampsia and fetal growth restriction were different from normal pregnancies at full term.

"Ours is the first study to examine LOI in the first trimester and compare it to that of full-term placentas," Dr. Lee said. "Now that we know the epigenetic make-up in the placenta changes during the course of a pregnancy, we can develop biomarkers to see if those pregnancies destined to develop preeclampsia or fetal growth restriction can be detected early enough in pregnancy to allow prevention of these diseases."

An estimated 10 percent of pregnancies are complicated by fetal growth restriction, which increases the risk of stillbirth, cerebral palsy, feeding intolerance, and failure to thrive. Preeclampsia, a condition characterized by high blood pressure and swelling during pregnancy, affects between 7 and 10 percent of pregnant women.

"More research is necessary to determine the impact of this discovery on potentially reducing the risk of other serious conditions like autism, cancer, and childhood obesity," said Dr. Lee.


'/>"/>

Contact: Mount Sinai Press Office
newsnow@mountsinai.org
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Related medicine news :

1. Casual Sex Doesnt Cause Emotional Damage: Study
2. Study Finds Possible Explanation for the Link Between Infertility and Breast/Ovarian Cancer Risks
3. Screening for Spinal Muscular Atrophy Not Cost-Effective: Study
4. New study finds possible source of beta cell destruction that leads to Type 1 diabetes
5. New Study Demonstrates Novel Use of Metabolic Imaging to Locate Sperm in Infertile Men -- Non-Invasive Imaging Procedure May Replace Invasive Techniques such as Testicula
6. Risk of stroke lower for recent Ontario immigrants: study
7. Definitive study confirms chemo benefit in postmenopausal breast cancer
8. Experimental stem cell treatment arrests acute lung injury in mice, study shows
9. Violence is part of the job say nurses as study shows only 1 in 6 incidents are reported
10. Controversial Autism Study Retracted by Medical Journal
11. Study Reveals Impact Of Health Insurance On Hispanics' Attitudes Towards Healthcare Providers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... ... in the greater Dallas, Miami, and Raleigh regions, is organizing an extended charity ... a rare and deadly chromosome abnormality. , After struggling since birth with several ...
(Date:10/13/2017)... ... October 13, 2017 , ... The American Board of Family Medicine's ... President and Chief Executive Officer, succeeding Dr. James C. Puffer upon his retirement. Dr. ... 2018 until Dr. Puffer’s retirement at the end of 2018. Upon assuming the role ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Lori R. Somekh, ... member of ElderCounsel, a national organization of elder law and special needs planning attorneys. ... and rules. It also provides a forum to network with elder law attorneys nationwide,” ...
(Date:10/13/2017)... ... 2017 , ... Ellevate Network, the leading network for professional women, brought together ... equality at their inaugural Summit in New York City in June. The event was ... of over 3 million. To watch the Mobilize Women video, click here . ...
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, ... Development, has been awarded a contract by the Center for Medicare and Medicaid ... to accelerate the enterprise use of Agile methodologies in a consistent and high ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... , Oct. 10, 2017   West Pharmaceutical Services, ... solutions for injectable drug administration, today shared the results ... Adapter for improving the intradermal administration of polio vaccines. ... Vaccination Summit in May 2017 by Dr. Ondrej ... Department, World Health Organization (WHO), and recently published in ...
(Date:10/4/2017)... OBP Medical , a leading ... today announced regulatory approval from Brazil,s ... Nacional de Vigilância Sanitária (ANVISA)) to market ... with integrated LED light source and smoke evacuation ... of a tissue pocket or cavity during surgical ...
(Date:10/2/2017)... 2, 2017 The Rebound mobile app is poised ... reverse the tide of prescription drug addiction. The app empowers ... intake and stepping down their dosage in a safe, controlled ... December 2017; the first 100,000 people to sign up will ... http://www.rebound-solution.com/ ...
Breaking Medicine Technology: