Navigation Links
Study finds changes in fetal epigenetics throughout pregnancy
Date:4/14/2010

Researchers at Mount Sinai School of Medicine have found that epigenetic marks on human placentas change from the first trimester of pregnancy to the third, a discovery that may allow clinicians to prevent complications in pregnancy.

The finding marks a dramatic departure from the prevailing opinion that epigenetic programming is permanently established 12 weeks after fertilization. Published in the April issue of the American Journal of Obstetrics and Gynecology, the study indicates that clinicians may be able to change the course of a pregnancy through early diagnosis and treatment.

"Our research shows that there are several 'windows of opportunity' during pregnancy to detect risks and also change pregnancy outcomes that may arise later," said the study's senior investigator, Men-Jean Lee, MD, Associate Professor, Obstetrics, Gynecology and Reproductive Science, and Preventive Medicine, Mount Sinai School of Medicine. "We have developed an assay that can allow clinicians to diagnose problems early enough to potentially prevent conditions such as preeclampsia and fetal growth restriction."

Epigenetics generally refers to factors that modify how a gene behaves while not altering the DNA nucleotide sequence of the gene itself. The placenta contains a group of genes, known as "imprinted" genes, which regulate fetal growth. In healthy fetal development, one copy of these genes is normally active and the other copy is silent. Loss of imprinting (LOI) occurs when both sets of genes are reactivated, and is an indicator of potential complications such as preeclampsia and fetal growth restriction.

Using an LOI assay developed by James G. Wetmur, PhD, and Jia Chen, ScD, of Mount Sinai School of Medicine, the research team assessed LOI at the first trimester in 17 placentas and at full term in 14 different placentas. The surprising results showed that more LOI occurred in the first trimester than at full term.

Dr.
'/>"/>

Contact: Mount Sinai Press Office
newsnow@mountsinai.org
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Casual Sex Doesnt Cause Emotional Damage: Study
2. Study Finds Possible Explanation for the Link Between Infertility and Breast/Ovarian Cancer Risks
3. Screening for Spinal Muscular Atrophy Not Cost-Effective: Study
4. New study finds possible source of beta cell destruction that leads to Type 1 diabetes
5. New Study Demonstrates Novel Use of Metabolic Imaging to Locate Sperm in Infertile Men -- Non-Invasive Imaging Procedure May Replace Invasive Techniques such as Testicula
6. Risk of stroke lower for recent Ontario immigrants: study
7. Definitive study confirms chemo benefit in postmenopausal breast cancer
8. Experimental stem cell treatment arrests acute lung injury in mice, study shows
9. Violence is part of the job say nurses as study shows only 1 in 6 incidents are reported
10. Controversial Autism Study Retracted by Medical Journal
11. Study Reveals Impact Of Health Insurance On Hispanics' Attitudes Towards Healthcare Providers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/28/2014)... UWDress.com sells cheap tall cocktail ... greatly discounted dresses. Today, there is a new collection ... these dresses are offered at very low prices. It ... in the promotion launched by UWDress.com , UWDress.com is ... world, so the company has the power to ensure ...
(Date:11/28/2014)... November 28, 2014 The month of December ... 20,000 car accidents occurring in Florida every year in December ... importance of auto insurance policies. , "Optional auto insurance coverage ... insurance is not cheap I know, actually Florida is among ... are even higher, but what I see is that the ...
(Date:11/28/2014)... (PRWEB) November 28, 2014 Pathways ... December 2, 2014. This national movement was created to ... by giving to local charities and causes. This ... coincides with the kickoff of the holiday shopping season. ... to shopping and Cyber Monday is to online commerce. ...
(Date:11/28/2014)... Dr. Diane Walder, one of the South ... Dr. Bridgit Nolan to her practice as a cosmetic ... her dermatology residency at the University of Miami Miller ... Nolan to join her practice because of her ... only does Dr. Nolan strive to provide the utmost ...
(Date:11/28/2014)... 2014 Dr. Diane Walder, one of ... treatment to her practice called Ultrashape that is designed to ... inches in just six weeks. Ultrashape has been praised by ... in results when compared to other types of external fat ... it,” said Dr. Walder. , According to Dr. Walder, ...
Breaking Medicine News(10 mins):Health News:Graceful Tall Cocktail Dresses With New Features Just Added To UWDress.com 2Health News:Car Accident Attorney Sean M. Cleary on Auto Insurance Policies Essential for Florida Drivers 2Health News:Pathways Home Health & Hospice Joins #GivingTuesday; Annual Holiday Encourages Local Charitable Giving 2Health News:Pathways Home Health & Hospice Joins #GivingTuesday; Annual Holiday Encourages Local Charitable Giving 3Health News:Dr. Diane Walder Welcomes New Cosmetic Dermatologist to Practice 2Health News:Dr. Diane Walder Introduces New Fat Reduction Treatment Called Ultrashape 2Health News:Dr. Diane Walder Introduces New Fat Reduction Treatment Called Ultrashape 3
... Tampa, FL (Feb. 10, 2011) -- Preladenant, a non-dopaminergic ... receiving standard dopamine therapy, an international study led by ... of the double-blind, randomized clinical trial are reported online ... findings suggest that preladenant may offer a new supplemental ...
... More than two thousand physicians, some of ... in maternal-fetal medicine, especially high risk pregnancies, gathered ... to begin four days of intensive research presentations. ... Maternal-Fetal Medicine,s (SMFM) annual meeting, The Pregnancy Meeting ...
... By Steven Reinberg HealthDay Reporter , WEDNESDAY, ... implanted device monitors fluid build-up in the lungs of heart ... As a result, the device reduces hospitalizations and improves quality ... the build-up of fluid pressure in the lungs that causes ...
... Ga. Regular exercise improves the ability of ... do math, Georgia Health Sciences University researchers report. ... 11-year-olds all sedentary when the study started - ... regular, vigorous physical activity is a part of every ...
... more than twice as likely to develop ulcers than people ... study from researchers at the University of Toronto. ... were abused during childhood and those were diagnosed with peptic ... Professor and Sandra Rotman Chair at U of T,s Factor-Inwentash ...
... EPA phased out the widespread residential use of chlorpyrifos ... risks to child neurodevelopment, these compounds were largely replaced ... replacement insecticides remained unclear, as they had never been ... the first study to examine the effects of these ...
Cached Medicine News:Health News:Non-dopaminergic drug preladenant reduces motor fluctuations in patients with Parkinson's disease 2Health News:SMFM highlights significance of spina bifida research findings 2Health News:Wireless Device Can Cut Heart Failure-Related Hospitalizations 2Health News:Wireless Device Can Cut Heart Failure-Related Hospitalizations 3Health News:Exercise helps overweight children think better, do better in math 2Health News:Common insecticide used in homes associated with delayed mental development of young children 2Health News:Common insecticide used in homes associated with delayed mental development of young children 3
(Date:11/26/2014)... Scott Steiger lives in St. ... an engineer for the past 20 years, he,s traveled extensively and ... He,s been to six of the seven continents. Travel is a ... http://photos.prnewswire.com/prnh/20141126/161076 Photo - http://photos.prnewswire.com/prnh/20141126/161077 So ... pretty good idea of what,s required. His latest creation ...
(Date:11/26/2014)... -- A hernia is condition in which a ... wall of a weak muscle area. Obesity, poor nutrition, smoking, ... the causes of hernias. There are several types of hernia ... hernia is when part of the abdominal tissue/organ protrudes into ... area of the umbilicus. A hiatal hernia is when a ...
(Date:11/26/2014)...  CARsgen, a leader in the development of Chimeric ... variety of cancers, today announced the completion of a ... China -based healthcare private equity fund.   ... development of new therapeutics for liver, lung, stomach and ... Shanghai Renji Hospital, the company plans to initiate clinical ...
Breaking Medicine Technology:Steiger Has Created the First Pill Case Specifically Designed For Travel 2Global Hernia Repair Devices Market Size, Share, Trends and Forecast 2014 to 2018 - Big Market Research 2Global Hernia Repair Devices Market Size, Share, Trends and Forecast 2014 to 2018 - Big Market Research 3Global Hernia Repair Devices Market Size, Share, Trends and Forecast 2014 to 2018 - Big Market Research 4CARsgen Completes Series A Financing 2
... and Company,(NYSE: LLY ), strongly disagrees with ... Connecticut Attorney General Richard Blumenthal,in a news release ... content of the release is a disservice to ... a life-threatening disease.,Specifically, the news release contained no ...
... a Hint of a Mutation,s Ancestral African Origin -, ... another group,s discovery of an important gene,associated with obesity, ... DNA that may be more helpful in identifying this ... finding suggests that,the gene variant, identified in DNA from ...
Cached Medicine Technology:Statement from Eli Lilly and Company: Response to Connecticut Attorney General News Release 2Statement from Eli Lilly and Company: Response to Connecticut Attorney General News Release 3Statement from Eli Lilly and Company: Response to Connecticut Attorney General News Release 4Gene Hunters Fine-Tune Marker for Common Obesity Gene 2Gene Hunters Fine-Tune Marker for Common Obesity Gene 3
... Package is a solid solution ... The package includes the Vibratome ... mounting blocks, v-block adapter, specimen ... rotating stage assembly for ease ...
... System provides a versatile means of sectioning ... The 1500 employs a vibrating blade ... embedding. The creation of artifacts, the ... activities, and other deleterious effect inherent in ...
... Vibratome 3000 Deluxe Sectioning System provides a ... animal, or plant tissues. The 3000 ... sectioning without freezing or embedding. The ... the destruction of enzyme activities, and other ...
The V-Block adapter is designed to allow round posts to be placed in the Vibratome vice....
Medicine Products: