Navigation Links
Study finds certain liver disease related to cardiovascular fitness
Date:3/24/2008

Patients with nonalcoholic fatty liver disease (NAFLD) have suboptimal levels of cardiovascular fitness, muscle strength, body composition and physical fitness, according to a new study. The findings appear in the April issue of Hepatology, a journal of the American Association for the Study of Liver Diseases (AASLD). The article is also available online at Wiley Interscience (www.interscience.wiley.com).

About one-in-four U.S. adults suffers from NAFLD, which describes a range of liver disease characterized by excessive fat in the liver. NAFLD is the most common cause of abnormal liver enzymes, and the leading reason for referrals to hepatology clinics. It is considered by many to be a manifestation of the metabolic syndrome which is less prevalent among physically fit people, but little is known about the relationship between fitness and NAFLD severity.

To address this question, researchers led by Joanne Krasnoff of the University of California San Francisco recruited 37 adult patients with a spectrum of NAFLD severity as measured by liver biopsy. Across the spectrum of NAFLD severity, patients had suboptimal cardiorespiratory fitness, muscle strength, body composition and physical activity participation. More than 97 percent had a body fat percentage that put them at increased risk for morbidity and mortality and less than 20 percent currently met recommended guidelines for physical activity.

The study did demonstrate lower cardiorespiratory fitness in subjects with increasing NAFLD severity. This provocative finding raised the question of a cause-or-effect phenomenondoes cardiorespiratory fitness attenuate NAFLD or does increasing NAFLD severity result in a decline in cardiorespiratory fitness" the authors ask.

Despite our study limitations, the authors conclude, we believe the objective demonstration of low cardiorespiratory fitness and muscle strength with a high incidence of obesity illustrates the potential clinical relevance of these measures both before and after interventions. Moreover, the finding that specific measures of NAFLD severity may be associated with cardiorespiratory fitness and past physical activity raises the possibility of a defined therapeutic role for prevention and exercise intervention.

Future studies should include a randomized controlled trial of exercise training that can reveal its direct effects on NAFLD histopathology, they suggest. In the meantime, it would appear rational and prudent for healthcare providers to recommend exercise training to improve health-related fitness as an integral role in the care of patients with NAFLD, they conclude. This work was conducted as an ancillary study of the NAFLD Clinical Research Network, a national research consortium funded by the National Institutes of Health.


'/>"/>

Contact: Sean Wagner
swagner@bos.blackwellpublishing.com
781-388-8550
Blackwell Publishing Ltd.
Source:Eurekalert

Related medicine news :

1. Study: Dramatic rise in hepatitis C-related deaths in the United States
2. St. Jude study offers new hope for children with kidney tumors deemed inoperable
3. U.S. Army Study Reports WoundStat(TM) is Most Effective
4. APIC Launches First National C. Difficile Prevalence Study
5. New Lung Association Study Shows $142 Billion Benefit of Converting to Zero-Emission Vehicles by 2030
6. APIC launches first national C. difficile prevalence study
7. Cato Study Finds Iran a Surprising Model for Kidney Markets
8. $2.4 million grant for study of corneal infections associated with contact lenses
9. Study Finds Single Dose of Iomai Patch With Pandemic Flu Vaccine Achieves Protective Levels
10. Disgusting videos used to study coping methods
11. Data study suggests cortisol could alleviate for chronic fatigue syndrome and fibromyalgia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2017)... (PRWEB) , ... July 24, 2017 , ... Engineers at ... bio-compatible, because it produces the same kind of electrical energy that the body uses. ... form of moving electrons. This flow of electrons out of the battery is generated ...
(Date:7/24/2017)... , ... July 24, 2017 , ... ... federal Substance Abuse and Mental Health Services Administration’s (SAMHSA) State Targeted Response to ... Department of Health Care Services, will facilitate the development of a hub and ...
(Date:7/24/2017)... ... July 24, 2017 , ... Every year, thousands of dedicated Higher ... InstructureCon. Each annual event is coupled with a dynamic theme like Camp Canvas; this ... theme, Mission: InstructureCon 0017. , To extend their partnership with Canvas beyond the ...
(Date:7/24/2017)... Beach, California (PRWEB) , ... July 24, 2017 ... ... commercialization of autologous fat (adipose) transfer systems announces the issuance of United States ... ‘324 patent) for its adipose filtration technology. The '398 and '324 patents ...
(Date:7/24/2017)... ... July 24, 2017 , ... Paul Vitenas, MD, FACS is excited to report ... invited to attend Allergan’s recent meeting with their Plastics Advisory Board. As one of ... Allergan is bringing a newly defined structure to the aesthetics market. Dr. Vitenas ...
Breaking Medicine News(10 mins):
(Date:7/17/2017)... 17, 2017  MedX Holdings, Inc., the manufacturer and ... and rehabilitation equipment, today announced the national roll out ... considered the gold standard for the treatment of low ... strengthening equipment. How ... physician or practice who prescribe the MedX Home Back ...
(Date:7/13/2017)... 13, 2017  Centurion Medical Products, a leader in medical product ... fecal impaction removal device for hospice patient care. ... Centurion Medical Products ... Patient pain management and emotional comfort are part ... alleviate patient pain while preventing unneeded emergency department admission due to ...
(Date:7/12/2017)... INDIANAPOLIS , July 12, 2017  Eli Lilly and ... settlement agreement with generic companies to resolve pending patent litigation ... Virginia regarding the Cialis ® ... expire on April 26, 2020. As part of the agreement, ... on September 27, 2018. "The unit dose patent ...
Breaking Medicine Technology: