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Study finds certain liver disease related to cardiovascular fitness
Date:3/24/2008

Patients with nonalcoholic fatty liver disease (NAFLD) have suboptimal levels of cardiovascular fitness, muscle strength, body composition and physical fitness, according to a new study. The findings appear in the April issue of Hepatology, a journal of the American Association for the Study of Liver Diseases (AASLD). The article is also available online at Wiley Interscience (www.interscience.wiley.com).

About one-in-four U.S. adults suffers from NAFLD, which describes a range of liver disease characterized by excessive fat in the liver. NAFLD is the most common cause of abnormal liver enzymes, and the leading reason for referrals to hepatology clinics. It is considered by many to be a manifestation of the metabolic syndrome which is less prevalent among physically fit people, but little is known about the relationship between fitness and NAFLD severity.

To address this question, researchers led by Joanne Krasnoff of the University of California San Francisco recruited 37 adult patients with a spectrum of NAFLD severity as measured by liver biopsy. Across the spectrum of NAFLD severity, patients had suboptimal cardiorespiratory fitness, muscle strength, body composition and physical activity participation. More than 97 percent had a body fat percentage that put them at increased risk for morbidity and mortality and less than 20 percent currently met recommended guidelines for physical activity.

The study did demonstrate lower cardiorespiratory fitness in subjects with increasing NAFLD severity. This provocative finding raised the question of a cause-or-effect phenomenondoes cardiorespiratory fitness attenuate NAFLD or does increasing NAFLD severity result in a decline in cardiorespiratory fitness" the authors ask.

Despite our study limitations, the authors conclude, we believe the objective demonstration of low cardiorespiratory fitness and muscle strength with a high incid
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Contact: Sean Wagner
swagner@bos.blackwellpublishing.com
781-388-8550
Blackwell Publishing Ltd.
Source:Eurekalert

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