Navigation Links
Study finds certain liver disease related to cardiovascular fitness
Date:3/24/2008

Patients with nonalcoholic fatty liver disease (NAFLD) have suboptimal levels of cardiovascular fitness, muscle strength, body composition and physical fitness, according to a new study. The findings appear in the April issue of Hepatology, a journal of the American Association for the Study of Liver Diseases (AASLD). The article is also available online at Wiley Interscience (www.interscience.wiley.com).

About one-in-four U.S. adults suffers from NAFLD, which describes a range of liver disease characterized by excessive fat in the liver. NAFLD is the most common cause of abnormal liver enzymes, and the leading reason for referrals to hepatology clinics. It is considered by many to be a manifestation of the metabolic syndrome which is less prevalent among physically fit people, but little is known about the relationship between fitness and NAFLD severity.

To address this question, researchers led by Joanne Krasnoff of the University of California San Francisco recruited 37 adult patients with a spectrum of NAFLD severity as measured by liver biopsy. Across the spectrum of NAFLD severity, patients had suboptimal cardiorespiratory fitness, muscle strength, body composition and physical activity participation. More than 97 percent had a body fat percentage that put them at increased risk for morbidity and mortality and less than 20 percent currently met recommended guidelines for physical activity.

The study did demonstrate lower cardiorespiratory fitness in subjects with increasing NAFLD severity. This provocative finding raised the question of a cause-or-effect phenomenondoes cardiorespiratory fitness attenuate NAFLD or does increasing NAFLD severity result in a decline in cardiorespiratory fitness" the authors ask.

Despite our study limitations, the authors conclude, we believe the objective demonstration of low cardiorespiratory fitness and muscle strength with a high incidence of obesity illustrates the potential clinical relevance of these measures both before and after interventions. Moreover, the finding that specific measures of NAFLD severity may be associated with cardiorespiratory fitness and past physical activity raises the possibility of a defined therapeutic role for prevention and exercise intervention.

Future studies should include a randomized controlled trial of exercise training that can reveal its direct effects on NAFLD histopathology, they suggest. In the meantime, it would appear rational and prudent for healthcare providers to recommend exercise training to improve health-related fitness as an integral role in the care of patients with NAFLD, they conclude. This work was conducted as an ancillary study of the NAFLD Clinical Research Network, a national research consortium funded by the National Institutes of Health.


'/>"/>

Contact: Sean Wagner
swagner@bos.blackwellpublishing.com
781-388-8550
Blackwell Publishing Ltd.
Source:Eurekalert

Related medicine news :

1. Study: Dramatic rise in hepatitis C-related deaths in the United States
2. St. Jude study offers new hope for children with kidney tumors deemed inoperable
3. U.S. Army Study Reports WoundStat(TM) is Most Effective
4. APIC Launches First National C. Difficile Prevalence Study
5. New Lung Association Study Shows $142 Billion Benefit of Converting to Zero-Emission Vehicles by 2030
6. APIC launches first national C. difficile prevalence study
7. Cato Study Finds Iran a Surprising Model for Kidney Markets
8. $2.4 million grant for study of corneal infections associated with contact lenses
9. Study Finds Single Dose of Iomai Patch With Pandemic Flu Vaccine Achieves Protective Levels
10. Disgusting videos used to study coping methods
11. Data study suggests cortisol could alleviate for chronic fatigue syndrome and fibromyalgia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2017)... Raton (PRWEB) , ... September 19, 2017 , ... ... the El Naturalista brand, developed by ACPG Laboratories, is coming soon to RonnieColemanNutrition.com. ... in Spain, and El Naturalista is a trusted, well-respected brand reliant on the ...
(Date:9/19/2017)... ... ... For decades doctors, nurses, and other healthcare providers have been trained to ... calculating their cardiovascular disease (CVD) risk in the next 10 years. , Imagine ... an estimated 10-year risk prediction! , Imagine if the weatherman says there is a ...
(Date:9/19/2017)... ... September 19, 2017 , ... ... with the Davidson Fellows Scholarship on September 27 at a reception in Washington ... Technology, Engineering, Mathematics, Literature and Music. , “I am honored to be a ...
(Date:9/19/2017)... ... September 19, 2017 , ... Emergency nursing expertise, skill ... Emergency Nurse (CEN®) certification according to a large-scale study announced today by ... conducted by the Human Resources Research Organization (HumRRO) in late 2016 and early ...
(Date:9/18/2017)... Bangkok, Thailand (PRWEB) , ... September 19, 2017 ... ... in Asia Pacific’s protein ingredient market , expected to grow at the ... Frost & Sullivan sharing the ‘Global Food Protein Trends & Growth Opportunities in ...
Breaking Medicine News(10 mins):
(Date:9/7/2017)... Sept. 7, 2017   BioLife Solutions , Inc. (NASDAQ: ... of proprietary clinical grade cell and tissue hypothermic storage ... Mike Rice , President and CEO, will be presenting ... Rodman & Renshaw 19 th Annual Global Investment ... (12:25 p.m. Pacific time). The conference is being held at ...
(Date:9/6/2017)... INDIANAPOLIS , Sept. 6, 2017 Eli ... today it will present new data for galcanezumab and ... Congress of the International Headache Society (IHC) taking place ... Lilly will highlight new, long-term data from ... two doses of galcanezumab (120 mg and 240 mg) ...
(Date:9/5/2017)... JERUSALEM , Sept. 5, 2017 Oramed Pharmaceuticals ... www.oramed.com ), a clinical-stage pharmaceutical company focused on the ... it has successfully concluded its meeting with the U.S. ... novel oral insulin formulation. ... that the regulatory pathway for submission of ORMD-0801, would ...
Breaking Medicine Technology: